isopropyl N-(α-naphthyl)-carbamate | 16827-25-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: isopropyl N-(α-naphthyl)-carbamate
• 英文别名: α-Naphthylurethan des Propanols-(2)；N-α-Naphthylcarbaminsaeureisopropylester；[1]naphthyl-carbamic acid isopropyl ester；[1]Naphthyl-carbamidsaeure-isopropylester；α-Naphthyl-carbamidsaeure-isopropylester；Isopropyl naphthalen-1-ylcarbamate；propan-2-yl N-naphthalen-1-ylcarbamate
• CAS: 16827-25-1
• 化学式: C₁₄H₁₅NO₂
• mdl: MFCD00087845
• 分子量: 229.279
• InChiKey: AEOQMGVPGAAJQS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.214
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  isopropyl N-(α-naphthyl)-carbamate 、 氯化苄 在 苄基三甲基氯化铵 作用下， 以 sodium hydroxide 、 二氯甲烷 为溶剂， 生成 isopropyl N-(α-naphthyl)-N-benzyl carbamate
  参考文献：
  名称：

  1H dynamic nuclear magnetic resonance study of hindered rotations inN-aryl-N-benzyl alkyl carbamates

  摘要：

  AbstractThe NMR variable temperature behaviour of a series of N‐aryl‐N‐benzyl alkyl carbamates was investigated. The barrier to rotation about the N‐aryl bond was determined for all the compounds studied. The values obtained, which are in good agreement with those found for structurally related N‐aryl‐N‐benzylamides, are in the range ΔG≠ = 60.7‐89.6kJ mol−1. For some carbamates another conformational phenomenon has been observed, namely the hindered rotation about the carbonyl carbon–nitrogen bond, with a barrier to rotation corresponding to reported values for similar systems.

  DOI：

  10.1002/omr.1270210912
• 作为产物：
  描述：

  1-萘胺 、 氯甲酸异丙酯 在 乙醇 作用下， 生成 isopropyl N-(α-naphthyl)-carbamate
  参考文献：
  名称：

  Spica; de Varda, Gazzetta Chimica Italiana, 1887, vol. 17, p. 165,168

  摘要：

  DOI：

文献信息

• Flame retarding resin composition
  申请人：——

  公开号：US20040077821A1

  公开（公告）日：2004-04-22

  Disclosed is a flame retarding resin composition comprising (A) one or more epoxy resins; (B) a hardener; and (C) a hardening accelerator, wherein the hardener of the component B is a phosphorus-containing compound represented by the following formula (I): 1 wherein each symbol is as defined below. The flame retarding resin composition of the present invention without adding halogen or other flame retardants has high flame retardancy and excellent heat resistance. The flame retarding resin composition of the present invention is suitably useful in the application of thermosetting resins, thermoplastic resins, bonding sheets, composite materials, laminated plates, printed circuit boards, copper foil adhesives, inks used for build-up process, semiconductor molding materials and the like.

  本发明公开了一种阻燃树脂组合物，该组合物包含(A)一种或多种环氧树脂；(B)一种固化剂；以及(C)一种硬化促进剂，其中成分 B 的固化剂是由下式(I)表示的含磷化合物： 1 其中各符号定义如下。本发明的阻燃树脂组合物不添加卤素或其他阻燃剂，具有高阻燃性和优异的耐热性。本发明的阻燃树脂组合物适用于热固性树脂、热塑性树脂、粘合片、复合材料、层压板、印刷电路板、铜箔粘合剂、用于堆积工艺的油墨、半导体成型材料等。
• Neuberg; Kansky, Biochemische Zeitschrift, 1909, vol. 20, p. 447
  作者：Neuberg、Kansky

  DOI：——

  日期：——
• GINEBREDA, A.;JULIA, S.;SANCHO, M.;SALA, P.;ANNUNZIATA, R., AFINIDAD, 1984, 41, N 390, 190-192
  作者：GINEBREDA, A.、JULIA, S.、SANCHO, M.、SALA, P.、ANNUNZIATA, R.

  DOI：——

  日期：——
• Use Of 3-Substituted-2-(Diphenylmethy)-1-Azabicyclo[2.2.2]Octanes For Treating Mrg-X1 Receptor Mediated Diseases
  申请人：Kunapuli Priya

  公开号：US20080027095A1

  公开（公告）日：2008-01-31

  The invention encompasses a method for treating a disease or condition mediated by the human MRG-X1 receptor, such as nociception, hyperalgesia, allodynia, pain related to central hypersensitivity conditions, somatic pain, visceral pain, acute pain, chronic pain, post-operative pain, headache, inflammatory pain, neurological pain, musculoskeletal pain, cancer related pain or vascular pain, in a human patient in need thereof comprising administering to the patient a therapeutically effective amount of a 3-substituted-2-(diphenylmethy)-1-azabicyclo[2.2.2]octane or a pharmaceutically acceptable salt thereof. The invention is also directed to the use of these compounds as molecular tools to directly explore the role of the MRG-X1 receptor in pain perception.
• METHODS AND COMPOSITIONS FOR TREATING OR PREVENTING PRURITIS
  申请人：Dong Xinzhong

  公开号：US20120073001A1

  公开（公告）日：2012-03-22

  The invention features therapeutic compositions comprising agents useful for the treatment or prevention of pruritis, and methods useful for identifying such agents.