N-(4-乙氧基苄基)-n-甲胺 | 41690-86-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-(4-乙氧基苄基)-n-甲胺
• 英文名称: (4-ethoxy-benzyl)-methyl-amine
• 英文别名: (4-Aethoxy-benzyl)-methyl-amin；N-(4-ethoxybenzyl)-N-methylamine；1-(4-ethoxyphenyl)-N-methylmethanamine
• CAS: 41690-86-2
• 化学式: C₁₀H₁₅NO
• mdl: MFCD04622318
• 分子量: 165.235
• InChiKey: XQYGQAVOILJHDN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 安全说明：
  S26,S36/37/39
• 危险类别码：
  R36/37/38
• 海关编码：
  2922299090

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: N-(4-Ethoxybenzyl)-n-methylamine
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: N-(4-Ethoxybenzyl)-n-methylamine
CAS number: 41690-86-2

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C10H15NO
Molecular weight: 165.2

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  N-(4-乙氧基苄基)-n-甲胺 生成 (4-ethoxy-benzyl)-trimethyl-ammonium; iodide
  参考文献：
  名称：

  Mndshojan et al., Izvestiya Akademii Nauk Armyanskoi SSR, Khimicheskie Nauki, 1958, vol. 11, p. 281,282, 283

  摘要：

  DOI：
• 作为产物：
  描述：

  4-乙氧基苯甲酰氯 在 lithium aluminium tetrahydride 作用下， 生成 N-(4-乙氧基苄基)-n-甲胺
  参考文献：
  名称：

  Mndshojan et al., Izvestiya Akademii Nauk Armyanskoi SSR, Khimicheskie Nauki, 1958, vol. 11, p. 281,282, 283

  摘要：

  DOI：

文献信息

• [EN] PDE4 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS<br/>[FR] INHIBITEURS DE PDE4, COMPOSITIONS PHARMACEUTIQUES ET APPLICATIONS THÉRAPEUTIQUES
  申请人：BIOTHERYX INC

  公开号：WO2021119571A1

  公开（公告）日：2021-06-17

  Provided herein are phosphodiesterase 4 (PDE4) inhibitors, e.g., a compound of Formula (I) or (II), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a disease, disorder, or condition associated with PDE4 malfunction.

  提供的是磷酸二酯酶4（PDE4）抑制剂，例如，公式（I）或（II）的化合物，以及它们的药物组合物。还提供了使用它们来治疗、预防或改善与PDE4功能障碍相关的一种或多种疾病、紊乱或症状的方法。
• PHENYLPROPIONIC ACID DERIVATIVE AND USE THEREOF
  申请人：MORITA Kohei

  公开号：US20100093819A1

  公开（公告）日：2010-04-15

  A compound represented by the following general formula (1) or a salt thereof, which has superior inhibitory activity against type 4 PLA 2 , and thus has prostaglandin and/or leucotriene production suppressing action [X represents a halogen atom, an alkyl group which may be substituted, or the like, Y represents hydrogen atom or an alkyl group which may be substituted, and Z represents hydrogen atom or an alkyl group which may be substituted].

  由以下一般式（1）表示的化合物或其盐，具有优越的抑制对4型PLA2的活性，因此具有前列腺素和/或白三烯产生抑制作用【X代表卤素原子、可能被取代的烷基或类似物，Y代表氢原子或可能被取代的烷基，Z代表氢原子或可能被取代的烷基】。
• THIAZOLINE AND OXAZOLINE DERIVATIVES AND THEIR METHODS OF USE
  申请人：Faghih Ramin

  公开号：US20080070929A1

  公开（公告）日：2008-03-20

  The invention relates to a series of thiazoline and oxazoline derivatives, compositions thereof, and methods of treating conditions and disorders using such compounds.

  这项发明涉及一系列噻唑啉和噁唑啉衍生物，其组成物和利用这些化合物治疗疾病和疾病的方法。
• Thiazoline and Oxazoline Derivatives and Their Methods of Use
  申请人：Faghih Ramin

  公开号：US20100190776A1

  公开（公告）日：2010-07-29

  The invention relates to a series of thiazoline and oxazoline derivatives, compositions thereof, and methods of treating conditions and disorders using such compounds.

  本发明涉及一系列噻唑啉和噁唑啉衍生物、其组成物以及使用这些化合物治疗病症和疾病的方法。
• Shapiro et al., Journal of the American Chemical Society, 81<1959><3728,3733
  作者：Shapiro et al.

  DOI：——

  日期：——