N-(4-乙氧基苯基)丙酰胺 | 19314-14-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-(4-乙氧基苯基)丙酰胺
• 英文名称: N-(4-ethoxyphenyl)propionamide
• 英文别名: propionic acid p-phenetidide；Propionsaeure-p-phenetidid；4-Propionylamino-phenetol；4-Propionylamino-phenol-aethylaether；N-(4-Ethoxyphenyl)propanamide
• CAS: 19314-14-8
• 化学式: C₁₁H₁₅NO₂
• mdl: MFCD00157585
• 分子量: 193.246
• InChiKey: HRLXPZIYSKPJFR-UHFFFAOYSA-N

物化性质

• 熔点：
  120 °C
• 沸点：
  365.8±25.0 °C(Predicted)
• 密度：
  1.076±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.363
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(4-乙氧基苯基)丙酰胺 在 五氯化磷 、 苯 作用下， 生成 4-[N-(4-ethoxy-phenyl)-propionimidoylamino]-benzoic acid ethyl ester
  参考文献：
  名称：

  Hill, Cox, Journal of the American Chemical Society, 1926, vol. 48, p. 3218

  摘要：

  DOI：
• 作为产物：
  描述：

  对乙氧基苯胺 、 3,5-庚烷二酮 在 双氧水 作用下， 以 水 为溶剂， 反应 8.0h， 以85%的产率得到N-(4-乙氧基苯基)丙酰胺
  参考文献：
  名称：

  H2O2-mediated oxidative formation of amides from aromatic amines and 1,3-diketones as acylation agents via C–C bond cleavage at room temperature in water under metal-free conditions

  摘要：

  1,3-二酮作为新型酰化试剂，在室温下以水为反应介质，在无金属的条件下，依靠商业可得的30%水合过氧化氢（H2O2）作为唯一氧化剂，与芳香胺反应，形成了一种新颖且快速的酰胺键形成策略。该方法具有高产率、简单温和，是首次通过C–C键断裂使用1,3-二酮作为酰化试剂的例子。

  DOI：

  10.1039/c3gc41260a

文献信息

• COATING AGENT
  申请人：Nippon Soda Co., Ltd.

  公开号：US20150353738A1

  公开（公告）日：2015-12-10

  It is an object to provide a coating agent that can form a layer having excellent adhesiveness to a plastic substrate and having transparency and a high refractive index. The coating agent of the present invention comprises a compound represented by formula (I) [wherein A represents a phenyl group or a naphthyl group optionally having an electron-donating group as a substituent; Z represents a carbon atom or a silicon atom, R 2 represents a hydrogen atom, a hydroxyl group, a linear or branched alkyl group, a linear or branched alkoxy group, a cyclic alkyl group, or a cyclic alkoxy group, X represents a single bond; an alkylene group optionally comprising an oxygen atom, a sulfur atom, a selenium atom, —NR—, a divalent aliphatic ring group, an arylene group, an amide structure or a urethane structure; a divalent aliphatic ring group; or an arylene group, Y represents a polymerizable functional group, n represents an integer of 2 or 3, m represents an integer of 1 or 2, l represents an integer of 0 or 1, and n+m+l=4; and when n represents an integer of 2 or 3, A is the same or different].

  本发明旨在提供一种涂层剂，该涂层剂能够形成与塑料基材具有良好粘附性、透明度和高折射率的层。本发明的涂层剂包括由式（I）表示的化合物[其中A表示苯基或萘基，可选地具有电子给体基团作为取代基；Z表示碳原子或硅原子，R2表示氢原子、羟基、线性或支链烷基、线性或支链烷氧基、环状烷基或环状烷氧基；X表示单键；一种包括氧原子、硫原子、硒原子、-NR-、二价脂肪环基、芳基环或酰胺结构或脲结构的烷基链可选地包括的烷基链；二价脂肪环基；或芳基环；Y表示可聚合的功能基团，n表示2或3的整数，m表示1或2的整数，l表示0或1的整数，且n+m+l=4；当n表示2或3的整数时，A相同或不同]。
• Shp-2 Inhibitors, Pharmaceutical Compositons Comprising Them and Their Use For Treating Phosphatase-Mediated Diseases
  申请人：Hellmuth Klaus

  公开号：US20080194563A1

  公开（公告）日：2008-08-14

  The present invention relates to small molecule protein tyrosine phosphatase inhibitors, especially Shp-2 inhibitors, of formula (I) and/or (II), and to pharmaceutical compositions comprising them. The invention is also directed to the use of said compounds for the treatment of phosphatase-mediated diseases, especially cancer and metastasis. The invention further concerns a method for treating a proliferative disease, a genetic disorder, an autoimmune disease, an angiogenic disorder or cancer in a patient in need of such treatment, comprising administering to said patient a therapeutically effective amount of at least one compound of formula (I) and/or (II).

  本发明涉及小分子蛋白酪氨酸磷酸酶抑制剂，特别是Shp-2抑制剂，其化学式为(I)和/或(II)，以及包含它们的制药组合物。该发明还涉及使用所述化合物治疗磷酸酶介导的疾病，特别是癌症和转移。本发明还涉及一种治疗增殖性疾病、遗传性疾病、自身免疫性疾病、血管生成障碍或癌症的方法，包括向该患者施用至少一种化合物(I)和/或(II)的治疗有效量。
• Reductive coupling of nitroarenes with carboxylic acids – a direct route to amide synthesis
  作者：Mikhail A. Losev、Andrey S. Kozlov、Vladimir B. Kharitonov、Oleg I. Afanasyev、Fedor S. Kliuev、Ludmila A. Bulygina、Natalya S. Khrushcheva、Dmitry A. Loginov、Denis Chusov

  DOI：10.1039/d3ob01452e

  日期：——

  A straightforward and selective way for the preparation of amides from nitroarenes and carboxylic acids using carbon monoxide as a reductant was developed. This protocol does not require any non-gaseous additives, thus simplifying product isolation. Aliphatic carboxylic acid was modified in the presence of aromatic ones, and reducible functional groups such as CC, Ar–Br, and R–NO2 were saved.

  开发了一种使用一氧化碳作为还原剂从硝基芳烃和羧酸制备酰胺的直接且选择性的方法。该方案不需要任何非气态添加剂，从而简化了产品分离。脂肪族羧酸在芳香族羧酸存在下进行改性，并保留了可还原的官能团，如C C、Ar–Br和R–NO 2 。
• IDO inhibitors
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US10167254B2

  公开（公告）日：2019-01-01

  There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

  本发明公开了调节或抑制吲哚胺-2,3-二氧化酶（IDO）酶活性的化合物、含有上述化合物的药物组合物以及利用本发明化合物治疗增殖性疾病（如癌症、病毒感染和/或炎症性疾病）的方法。
• Inhibitors of indoleamine-2,3-dioxygenase for the treatment of cancer
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US10399933B2

  公开（公告）日：2019-09-03

  There are disclosed compounds of formula (I) that modulate or inhibit the enzymatic activity of indoleamine-2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

  本发明公开了调节或抑制吲哚胺-2,3-二氧化酶（IDO）酶活性的式(I)化合物、含有所述化合物的药物组合物以及利用本发明化合物治疗增殖性疾病（如癌症、病毒感染和/或炎症性疾病）的方法。