(3,4-Dichlorophenyl)-(tetrahydropyran-2-yl) Acetic Acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3,4-Dichlorophenyl)-(tetrahydropyran-2-yl) Acetic Acid
• 英文别名: 2-(3,4-Dichlorophenyl)-2-(oxan-2-yl)acetic acid
• 化学式: C₁₃H₁₄Cl₂O₃
• 分子量: 289.158
• InChiKey: VJCDXPLNCNESKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Compounds with high monoamine transporter affinity
  申请人：——

  公开号：US20040014992A1

  公开（公告）日：2004-01-22

  Featured compounds have high monoamine transport affinity and are characterized by one of the following two general formulas set out above. The compounds bind selectively or non-selectively to monoamine transporters. The compounds are useful to treat various medical indications including attention deficit hyperactivity disorder (ADHD), Parkinson's disease, cocaine addiction, smoking cessation, weight reduction, obsessive-compulsive disorder, various forms of depression, traumatic brain injury, stroke, and narcolepsy.

  特色化合物具有高单胺转运亲和力，并具有以下两个通用公式中的一个特征。这些化合物具有选择性或非选择性地结合到单胺转运体上。这些化合物可用于治疗各种医学适应症，包括注意力缺陷多动障碍（ADHD）、帕金森病、可卡因成瘾、戒烟、减轻体重、强迫症、各种形式的抑郁症、创伤性脑损伤、中风和嗜睡症。
• COMPOUNDS WITH HIGH MONOAMINE TRANSPORTER AFFINITY
  申请人：PRESIDENT AND FELLOWS OF HARVARD COLLEGE

  公开号：EP1366007A2

  公开（公告）日：2003-12-03
• US6525206B1
  申请人：——

  公开号：US6525206B1

  公开（公告）日：2003-02-25
• US7026516B2
  申请人：——

  公开号：US7026516B2

  公开（公告）日：2006-04-11
• [EN] COMPOUNDS WITH HIGH MONOAMINE TRANSPORTER AFFINITY<br/>[FR] COMPOSES A FORTE AFFINITE POUR UN TRANSPORTEUR DE MONOAMINE
  申请人：HARVARD COLLEGE

  公开号：WO2002032842A2

  公开（公告）日：2002-04-25

  Compounds have high monoamine transport affinity and are characterized by one of the following two general formulas set out below in which the variables are as defined in the claims. The compounds bind selectively or non-selectively to monoamine transporters. The compounds are useful to treat various medical indications including, without limitation, attention deficit hyperactivity disorder (ADHD), Parkinson's disease, cocaine addiction, smoking cessation, weight reduction, obsessive-compulsive disorder, various forms of depression, traumatic brain injury, stroke, and narcolepsy.