diethyl 2-amino-1-fluoro-2-phenylethylphosphonate | 1265968-77-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: diethyl 2-amino-1-fluoro-2-phenylethylphosphonate
• 英文别名: 2-Diethoxyphosphoryl-2-fluoro-1-phenylethanamine
• CAS: 1265968-77-1
• 化学式: C₁₂H₁₉FNO₃P
• 分子量: 275.26
• InChiKey: ATKWOUBKAMFLSF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  61.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (2-氧代-2-苯乙基)膦酸二乙酯 在 palladium 10% on activated carbon 、 氢气 、 Selectfluor 作用下， 以 乙醇 、 乙腈 为溶剂， 80.0 ℃ 、413.7 kPa 条件下， 反应 24.0h， 生成 diethyl 2-amino-1-fluoro-2-phenylethylphosphonate
  参考文献：
  名称：

  Selective Synthesis of α-Fluoro-β-keto- and α-Fluoro-β-aminophosphonates via Electrophilic Fluorination by Selectfluor

  摘要：

  A series of alpha-mono- and alpha,alpha-difluoro-beta-ketophosphonates were synthesized in moderate to good yields with excellent selectivities via electrophilic fluorination by Selectfluor. Subsequently, synthetic potential of the obtained alpha-monofluoro-beta-ketophosphonates was demonstrated by their application in synthesis of alpha-monofluoro-beta-aminophosphonates, useful building blocks in the preparation of phosphapeptides.

  DOI：

  10.1021/jo102276y

文献信息

• Selective Synthesis of α-Fluoro-β-keto- and α-Fluoro-β-aminophosphonates via Electrophilic Fluorination by Selectfluor
  作者：Kinga Radwan-Olszewska、Francisco Palacios、Pawel Kafarski

  DOI：10.1021/jo102276y

  日期：2011.2.18

  A series of alpha-mono- and alpha,alpha-difluoro-beta-ketophosphonates were synthesized in moderate to good yields with excellent selectivities via electrophilic fluorination by Selectfluor. Subsequently, synthetic potential of the obtained alpha-monofluoro-beta-ketophosphonates was demonstrated by their application in synthesis of alpha-monofluoro-beta-aminophosphonates, useful building blocks in the preparation of phosphapeptides.