2,3-diamino-thiazolium; 2,4,6-trimethyl-benzenesulfonate | 51578-86-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,3-diamino-thiazolium; 2,4,6-trimethyl-benzenesulfonate
• 英文别名: 2,3-diamino-thiazolium mesitylenesulfonate；1,3-Thiazol-3-ium-2,3-diamine;2,4,6-trimethylbenzenesulfonate
• CAS: 51578-86-0
• 化学式: C₃H₆N₃S*C₉H₁₁O₃S
• 分子量: 315.417
• InChiKey: YLMFMJQOTNHWFW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.85
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  150
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2,3-diamino-thiazolium; 2,4,6-trimethyl-benzenesulfonate 在 sodium hydroxide 作用下， 以 二氯甲烷 为溶剂， 生成 2-Imino-3-aminothiazolin
  参考文献：
  名称：

  噻唑并[3,2-的新颖合成b ] -小号-triazoles

  摘要：

  的反应的2-氨基和2- acylaminothiazoles与ö -mesitylenesulfonylhydroxylamine导致准备形成在相应的3-铵盐，将其转化成噻唑并[3,2- b ] -小号高收率-triazoles。

  DOI：

  10.1002/jhet.5570100611
• 作为产物：
  描述：

  2-氨基噻唑 、 2,4,6-三甲基苯磺酰羟胺 以 二氯甲烷 为溶剂， 生成 2,3-diamino-thiazolium; 2,4,6-trimethyl-benzenesulfonate
  参考文献：
  名称：

  噻唑并[3,2-的新颖合成b ] -小号-triazoles

  摘要：

  的反应的2-氨基和2- acylaminothiazoles与ö -mesitylenesulfonylhydroxylamine导致准备形成在相应的3-铵盐，将其转化成噻唑并[3,2- b ] -小号高收率-triazoles。

  DOI：

  10.1002/jhet.5570100611

文献信息

• Methods of Treating or Preventing Cardiac Disease Associated With a High Fat Diet
  申请人：Thomas Merlin

  公开号：US20090088461A1

  公开（公告）日：2009-04-02

  The present invention relates to a method of treating or preventing cardiac disorders, myocardial inflammation or myocardial oxidative stress associated with a high fat diet or in a patient subjected to a high fat diet using the thiazolium compounds and compositions of the invention. The present invention also relates to a method of ameliorating weight gain, myocardial AGE accumulation associated, mitochondrial superoxide production, RAGE expression or PPARα expression with a high fat diet or in a patient subjected to a high fat diet using the thiazolium compounds and compositions of the invention.

  本发明涉及一种使用该发明的噻唑类化合物和组合物治疗或预防与高脂饮食相关的心脏疾病、心肌炎症或心肌氧化应激的方法。本发明还涉及一种使用该发明的噻唑类化合物和组合物改善与高脂饮食相关的体重增加、心肌AGE积累、线粒体超氧化物产生、RAGE表达或PPARα表达的方法。
• Method and composition for rejuvenating hair, nails, tissues, cells and organs by ex-vivo or immersive treatment
  申请人：——

  公开号：US20020182165A1

  公开（公告）日：2002-12-05

  A method and composition for the treatment of hair, nail, ex-vivo organ, ex-vivo cell or ex-vivo tissue to improve the biomechanical and diffusional characteristics comprising an effective amount of a compound selected from the group consisting of compounds of the formula 1

  一种用于改善生物力学和扩散特性的头发、指甲、离体器官、离体细胞或离体组织的治疗方法和组合物，包括有效量的来自化合物公式1所述化合物组合的化合物。
• Method of treating certain indications associated with hyperglycemia
  申请人：——

  公开号：US20020192842A1

  公开（公告）日：2002-12-19

  The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, compositions are disclosed which comprise an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins, and which additionally reverse pre-formed crosslinks in the advanced glycosylation endproducts by cleaving alpha-dicarbonyl-based protein crosslinks present in the advanced glycosylation endproducts. Certain agents useful are thiazolium salts. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated. A novel immunoassay for detection of the reversal of the nonenzymatic crosslinking is also disclosed.

  本发明涉及用于抑制和逆转非酶促交联（蛋白质老化）的组合物和方法。因此，揭示了包括一种能够抑制目标蛋白质高级糖基化终产物的生成的药剂的组合物，并且通过断裂高级糖基化终产物中存在的基于α-二羰基的蛋白质交联物来逆转预先形成的交联。某些有用的药剂是噻唑盐。该方法包括将组合物与目标蛋白质接触。预计该发明具有工业和治疗应用，因为可以处理食品变质和动物蛋白质老化。还揭示了一种用于检测非酶促交联逆转的新型免疫测定法。
• Preventing and reversing the formation of advance glycosylation endproducts
  申请人：Cerami Anthony

  公开号：US20070025926A1

  公开（公告）日：2007-02-01

  The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, compositions are disclosed which comprise an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins, and which additionally reverse pre-formed crosslinks in the advanced glycosylation endproducts by cleaving alpha-dicarbonyl-based protein crosslinks present in the advanced glycosylation endproducts. Certain useful agents are thiazolium salts. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated. A novel immunoassay for detection of the reversal of the nonenzymatic crosslinking is also disclosed.

  本发明涉及用于抑制和逆转非酶促交联（蛋白老化）的组合物和方法。因此，披露了包含一种能够抑制目标蛋白质的高级糖基化终产物的形成的药剂的组合物，并且通过裂解在高级糖基化终产物中存在的α-二羰基基础蛋白交联来逆转预先形成的交联。某些有用的药剂是噻唑盐。该方法包括将目标蛋白质与该组合物接触。该发明既可以在工业上应用，也可以在治疗上应用，因为可以治疗食品变质和动物蛋白质老化。还披露了一种新型的免疫测定方法，用于检测非酶促交联的逆转。
• Use of thiazolium compounds for preventing and reversing the formation of advanced glycosylation end products
  申请人：Alteon, Inc.

  公开号：EP1327887A2

  公开（公告）日：2003-07-16

  The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, compositions are disclosed which comprise an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins, and which additionally reverse pre-formed crosslinks in the advanced glycosylation endproducts by cleaving alpha-dicarbonyl-based protein crosslinks present in the advanced glycosylation endproducts. Certain agents useful are thiazolium salts. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated. A novel immunoassay for detection of the reversal of the nonenzymatic crosslinking is also disclosed.

  本发明涉及抑制和逆转非酶交联（蛋白质老化）的组合物和方法。因此，本发明公开了包含能够抑制目标蛋白质晚期糖基化终产物形成的制剂的组合物，以及通过裂解晚期糖基化终产物中存在的基于α-二羰基的蛋白质交联，逆转晚期糖基化终产物中预先形成的交联的组合物。某些有用的制剂是噻唑盐。该方法包括将目标蛋白质与组合物接触。本发明既可用于工业，也可用于治疗，因为食品变质和动物蛋白老化都可以得到治疗。本发明还公开了一种检测非酶交联逆转的新型免疫测定法。