3,5-dimethyl-2-(pyrrolidin-1-yl)pyridine | 1259313-72-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3,5-dimethyl-2-(pyrrolidin-1-yl)pyridine
• 英文别名: 3,5-Dimethyl-2-pyrrolidin-1-ylpyridine
• CAS: 1259313-72-8
• 化学式: C₁₁H₁₆N₂
• 分子量: 176.261
• InChiKey: STTHFLDLVASDNZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  16.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  甲基硼酸 、 3,5-dibromo-2-(pyrrolidin-1-yl)pyridine 在 potassium fluoride 、 1,1'-双(二苯膦基)二茂铁二氯化钯(II)二氯甲烷复合物 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以62%的产率得到5-bromo-3-methyl-2-(pyrrolidin-1-yl)pyridine
  参考文献：
  名称：

  Cross-coupling reaction on N-(3,5-dibromo-2-pyridyl)piperazines: regioselective synthesis of 3,5-disubstituted pyridylpiperazines

  摘要：

  Unsymmetrical 3 5-disubstituted pyridylpiperazines were prepared from tribromopyridine in three coupling reactions Key to the success of the syntheses is the palladium-catalyzed regioselective cross-coupling reaction in the 3-position of N-(3 5-dibromo-2-pyridyl)piperazines (C) 2010 Elsevier Ltd All rights reserved

  DOI：

  10.1016/j.tet.2010.09.100

文献信息

• BENZODIAZEPINE COMPOUND AND PHARMACEUTICAL COMPOSITION
  申请人：Oshima Kunio

  公开号：US20100331317A1

  公开（公告）日：2010-12-30

  The present invention provides a novel benzodiazepine compound that blocks the I Kur current or the Kv1.5 channel potently and more selectively than other K + channels. The benzodiazepine compound of the invention is represented by General Formula (1) wherein R 1 , R 2 , R 3 , and R 4 are each independently hydrogen or lower alkyl; R 2 and R 3 may be linked to form lower alkylene; A 1 is lower alkylene optionally substituted with one or more hydroxy; and R 5 is group represented by wherein R 6 and R 7 are each independently hydrogen or organic group; X A and X B are each independently bond, lower alkylene, etc.

  本发明提供了一种新型苯二氮平化合物，它比其他K+通道更具有选择性地有效地阻断IKur电流或Kv1.5通道。本发明的苯二氮平化合物由通式（1）表示，其中R1、R2、R3和R4各自独立地表示氢或较低的烷基；R2和R3可以连接成较低的烷基；A1是较低的烷基，可以选择性地取代一个或多个羟基；R5是由下式表示的基团：其中R6和R7各自独立地表示氢或有机基团；XA和XB各自独立地表示键合、较低的烷基等。
• US8338406B2
  申请人：——

  公开号：US8338406B2

  公开（公告）日：2012-12-25
• Cross-coupling reaction on N-(3,5-dibromo-2-pyridyl)piperazines: regioselective synthesis of 3,5-disubstituted pyridylpiperazines
  作者：Hidemasa Hikawa、Yuusaku Yokoyama

  DOI：10.1016/j.tet.2010.09.100

  日期：2010.12

  Unsymmetrical 3 5-disubstituted pyridylpiperazines were prepared from tribromopyridine in three coupling reactions Key to the success of the syntheses is the palladium-catalyzed regioselective cross-coupling reaction in the 3-position of N-(3 5-dibromo-2-pyridyl)piperazines (C) 2010 Elsevier Ltd All rights reserved