7-methoxynaphtho[1,2-d]thiazol-2-amine | 1433958-81-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并噻唑类
• 英文名称: 7-methoxynaphtho[1,2-d]thiazol-2-amine
• 英文别名: 7-Methoxybenzo[e][1,3]benzothiazol-2-amine；7-methoxybenzo[e][1,3]benzothiazol-2-amine
• CAS: 1433958-81-6
• 化学式: C₁₂H₁₀N₂OS
• 分子量: 230.29
• InChiKey: ZGHZXWXZLRLGKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  76.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  硫脲 、 6-甲氧基-1-萘满酮 在 碘 、 氧气 、 对甲苯磺酸 作用下， 以 二甲基亚砜 为溶剂， 反应 24.0h， 生成 7-methoxynaphtho[1,2-d]thiazol-2-amine
  参考文献：
  名称：

  [EN] SK AND IK CHANNEL AGONISTS FOR TREATMENT OF HEART FAILURE
  [FR] AGENTS AGONISTES DES CANAUX SK ET IK POUR LE TRAITEMENT DE L'INSUFFISANCE CARDIAQUE

  摘要：

  本发明提供了改进的钾通道激动剂化合物。还提供了包括药用可接受载体和本发明化合物的制药组合物。还提供了用于治疗或缓解心力衰竭综合症、高血压和糖尿病的方法和工具包。还提供了包括本发明化合物的方法、工具包和组合物。

  公开号：

  WO2016191294A1

文献信息

• [EN] SK AND IK CHANNEL AGONISTS FOR TREATMENT OF HEART FAILURE<br/>[FR] AGENTS AGONISTES DES CANAUX SK ET IK POUR LE TRAITEMENT DE L'INSUFFISANCE CARDIAQUE
  申请人：UNIV COLUMBIA

  公开号：WO2016191294A1

  公开（公告）日：2016-12-01

  The present invention provides compounds that are improved potassium channel agonists. Pharmaceutical compositions including a pharmaceutically acceptable carrier and a compound of the present invention are also provided. Methods and kits for treating or ameliorating the effects of heart failure syndrome, high blood pressure and diabetes also are provided. Methods, kits and compositions which include compounds of the present invention also are provided.

  本发明提供了改进的钾通道激动剂化合物。还提供了包括药用可接受载体和本发明化合物的制药组合物。还提供了用于治疗或缓解心力衰竭综合症、高血压和糖尿病的方法和工具包。还提供了包括本发明化合物的方法、工具包和组合物。
• SK AND IK CHANNEL AGONISTS FOR TREATMENT OF HEART FAILURE
  申请人：THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

  公开号：US20180118699A1

  公开（公告）日：2018-05-03

  The present invention provides compounds that are improved potassium channel agonists. Pharmaceutical compositions including a pharmaceutically acceptable carrier and a compound of the present invention are also provided. Methods and kits for treating or ameliorating the effects of heart failure syndrome, high blood pressure and diabetes also are provided. Methods, kits and compositions which include compounds of the present invention also are provided.
• Metal-Free Synthesis of 2-Aminobenzothiazoles via Aerobic Oxidative Cyclization/Dehydrogenation of Cyclohexanones and Thioureas
  作者：Jinwu Zhao、Huawen Huang、Wanqing Wu、Huoji Chen、Huanfeng Jiang

  DOI：10.1021/ol400773k

  日期：2013.6.7

  A metal-free process for the synthesis of 2-aminobenzothiazoles from cyclohexanones and thioureas has been developed using catalytic iodine and molecular oxygen as the oxidant under mild conditions. Various 2-aminobenzothiazoles, 2-aminonaphtho[2,1-d]thiazoles, and 2-aminonaphtho[1,2-d]thiazoles were prepared via this method in satisfactory yields.