2-Amino-6-(hydrazinecarbonyl)benzoic acid | 6940-52-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Amino-6-(hydrazinecarbonyl)benzoic acid
• CAS: 6940-52-9
• 化学式: C₈H₉N₃O₃
• 分子量: 195.18
• InChiKey: YTOGAQVNTYYSOJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.9
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  118
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• Reagent for detecting occult blood
  申请人：Kazuo, Tabata

  公开号：EP0514030A1

  公开（公告）日：1992-11-19

  A reagent to be used in detection of occult blood comprising a mixed solution of sodium carbonate, 3-amino phthalic acid hydrazide, and iron and sodium derivative of ethylenediaminetetraacetic acid, and hydrogen peroxide.

  一种用于检测隐血的试剂，由碳酸钠、3-氨基邻苯二甲酸酰肼、乙二胺四乙酸铁和钠盐衍生物以及过氧化氢的混合溶液组成。
• BISPECIFIC ANTIBODY AND USE THEREOF
  申请人：Shandong New Time Pharmaceutical Co., Ltd.

  公开号：EP3889179A1

  公开（公告）日：2021-10-06

  A bispecific antibody, which specifically binds the surface antigen CD3 of immune cells and the BCMA antigen on the surface of tumor cells and which may bind to human CD3 with high affinity, induce T cell proliferation, and mediate tumor cell killing effects. The bispecific antibody may be used to mediate the T cell-specific killing of target cells in in vitro tests. The method for constructing a bispecific antibody is simple, and avoids the possibility of mismatching between two sets of light chains and heavy chains of a heterologous bispecific antibody, thus the difficulty of antibody purification is reduced, the affinity of the obtained antibody is high, the side effects of induced cytokines are few, and safety is high.

  一种双特异性抗体，它能特异性地与免疫细胞表面抗原 CD3 和肿瘤细胞表面的 BCMA 抗原结合，并能以高亲和力与人类 CD3 结合，诱导 T 细胞增殖，并介导肿瘤细胞杀伤效应。该双特异性抗体可用于体外试验中介导 T 细胞特异性杀伤靶细胞。本发明构建双特异性抗体的方法简单，避免了异源双特异性抗体两组轻链和重链不匹配的可能性，从而降低了抗体纯化的难度，获得的抗体亲和力高，诱导细胞因子的副作用小，安全性高。
• Crystalline form of 5-amino-2,3-dihydrophthalazine-1,4-dione sodium salt, pharmaceutical preparations containing the same and method for the production of said form
  申请人：METRIOPHARM AG

  公开号：US10258620B2

  公开（公告）日：2019-04-16

  The invention relates to the provision of a new crystalline form for 5-amino-2,3-dihydrophthalazine-1,4-dione sodium, the use of this form for medical purposes, methods for producing the crystalline form according to the invention, as well as pharmaceutical preparations comprising said form.

  本发明涉及 5-氨基-2,3-二氢酞嗪-1,4-二酮钠的一种新结晶形式、该形式在医疗方面的用途、根据本发明生产结晶形式的方法以及包含上述形式的药物制剂。
• Novel catalytic activities of oxidoreductases for oxidation and or bleaching
  申请人：Call Hans-Peter

  公开号：US20060054290A1

  公开（公告）日：2006-03-16

  A new enzyme-based process for oxidation and/or bleaching is described, comprising of oxidoreductases such as laccases and/or peroxidases—seperately or in combination—in the presence of their respective co-substrates like O 2 , air, H 2 O 2 , organic peroxides, peracids etc. and comprising of enhancer compounds from the class of oxocarbons, from the class of urazoles and hydrazides, from the class of hydantoins and the class of nitril (Cyan)-compounds, and comprising additionally of carbonyl compounds such as ketones, aldehyds, whereby the combination of enzyme, co-substrate, enhancer compound and carbonyl compound generate active oxygen species like dioxiranes, dioxetanes, peroxy-compounds etc. or form other reactive compounds or transition states like radicals (kation radicals, anion radicals) or reactive (red/ox-active) neutral compounds as oxidizing and/or bleaching agents.

  描述了一种新的以酶为基础的氧化和/或漂白工艺，包括氧化还原酶，如漆酶和/或过氧化物酶--单独或组合使用--在它们各自的辅助底物如 O 2 、空气、H 2 O 2 酶、辅助底物、促进剂化合物和羰基化合物的组合可产生活性氧，如二氧环烷、二氧杂环烷、过氧化合物等，或形成其他活性化合物或过渡态，如自由基（阴离子自由基）或活性（红色/氧化活性）中性化合物，作为氧化和/或还原剂。或形成其他活性化合物或过渡态，如自由基（阳离子自由基、阴离子自由基）或活性（红色/氧化活性）中性化合物，作为氧化剂和/或漂白剂。
• [EN] BIOSENSOR BASED ON TWO-CARBONIZED THREE-TITANIUM TWO-DIMENSIONAL METAL CARBIDE CATALYZED LUMINOL ELECTROCHEMILUMINESCENT PROBE, AND PREPARATION METHOD<br/>[FR] BIOCAPTEUR BASÉ SUR UNE SONDE ÉLECTROCHIMILUMINESCENTE DE LUMINOL À BASE DE CARBURE MÉTALLIQUE CATALYSÉ BIDIMENSIONNEL À TROIS TITANES ET DEUX CARBONES, ET PROCÉDÉ DE PRÉPARATION<br/>[ZH] 一种基于二碳化三钛二维金属碳化物催化鲁米诺电化学发光探针的生物传感器及制备方法
  申请人：UNIV QINGDAO

  公开号：WO2019200921A1

  公开（公告）日：2019-10-24

  一种基于二碳化三钛二维金属碳化物催化鲁米诺电化学发光探针的生物传感器，该生物传感器包括探针和生物传感器电极，其探针包括纳米片Ti 3C 2MXenes、连接分子和生物识别分子1，所述纳米片Ti 3C 2MXenes与连接分子通过静电吸附连接，所述连接分子与生物识别分子1通过酰胺基团连接，所述连接分子含有伯胺基团或仲胺基团，且所述连接分子溶于水后能够带有正电荷，所述生物识别分子1为5'端带有羧基的单链DNA序列1，所述单链DNA序列1能够识别外泌体上的CD63蛋白质。一种所述传感器的制备方法。利用Ti 3C 2MXenes改进鲁米诺的电致化学发光，并利用该性质将其制备成探针，进而制备了生物传感器。