Acetonitril-Pyrrol-Addukt | 14213-96-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: Acetonitril-Pyrrol-Addukt
• 英文别名: Pyrrole acetonitrile；acetonitrile;1H-pyrrole
• CAS: 14213-96-8
• 化学式: C₂H₃N*C₄H₅N
• 分子量: 108.143
• InChiKey: OWLPRNMVFSOBSL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.54
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  39.6
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] AZOLE METHYLIDENE CYANIDE DERIVATIVES AND THEIR USE AS PROTEIN KINASE MODULATORS<br/>[FR] DERIVES DE CYANURE D'AZOLE METHYLIDENE ET LEUR UTILISATION COMME MODULATEURS DE PROTEINE KINASE
  申请人：APPLIED RESEARCH SYSTEMS

  公开号：WO2003106455A1

  公开（公告）日：2003-12-24

  The present invention is related to azole derivatives notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such azole derivatives. Said azole derivatives are modulators of the protein kinase signalling pathways, particularly the one involving c-Jun N-terminal kinase and/or Glycogen Kinase Synthase 3. The present invention is furthermore related to novel azole derivatives as well as to methods of their preparation. X is O, S or NR0, with R0 being H or an unsubstituted or substituted C1 -C6 alkyl; A is 2-pyridyl, 3-pyridyl, 4-pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl or triazinyl group.

  本发明涉及唑衍生物，尤其是用作药物活性化合物的唑衍生物，以及包含这种唑衍生物的药物制剂。所述唑衍生物是蛋白激酶信号通路的调节剂，尤其是涉及c-Jun N端激酶和/或糖原合酶3的那一种。本发明还涉及新颖的唑衍生物以及它们的制备方法。X是O、S或NR0，其中R0是H或未取代或取代的C1-C6烷基；A是2-吡啶基，3-吡啶基，4-吡啶基，吡啶唑基，吡唑啉基，吡嗪基或三嗪基团。
• [EN] BENZOXAZOLE ACETONITRILES<br/>[FR] BENZOXAZOLE ACETONITRILES
  申请人：APPLIED RESEARCH SYSTEMS

  公开号：WO2005026159A1

  公开（公告）日：2005-03-24

  The present invention is related to benzoxazole acetonitriles as well as to pharmaceutical formulations containing such benzoxazole acetonitriles pof formula (I). Said benzoxazole acetonitriles are useful in the treatment of metabolic disorders mediated by insulin resistance or hyperglycernia, comprising diabetes type II, inadequate glucose tolerance, insulin resistance, obesity, polycystic ovary syndrome (PCOS). The present invention is furthermore related to methods of preparing benzoxazole acetonitriles (I). A is a pyrimidinyl.L is a secondary or tertiary amino group, or a 3-8 membered heterocycloalkyl, containing at least one heteroatom. selected from N, O, S or L is an acylarnino moiety.R1 is selected from the group comprising or consisting of hydrogen, sulfonyl, amino, CiC6-alkYl, C2-C6-alkenYl, C2-C6-alkynyl or Cl-C6-alkoxy, aryl, halogen, carboxy,aminocarbonyl, cyano or hydroxy.

  本发明涉及苯并噁唑乙腈，以及含有该苯并噁唑乙腈的药物配方（I）的制备方法。所述苯并噁唑乙腈在治疗由胰岛素抵抗或高甘油三酯引起的代谢紊乱方面具有用途，包括糖尿病II型、葡萄糖耐量不佳、胰岛素抵抗、肥胖、多囊卵巢综合征（PCOS）。A是嘧啶基。L是次级或三级氨基团，或者是含有至少一个来自N、O、S的杂原子的3-8环杂环烷基。R1选择自氢、磺酰基、氨基、CiC6-烷基、C2-C6-烯基、C2-C6-炔基、Cl-C6-烷氧基、芳基、卤素、羧基、氨基羰基、氰基或羟基。
• Azole methylidene cyanide derivatives and their use as protein kinase modulators
  申请人：Gaillard Pascale

  公开号：US20070123530A1

  公开（公告）日：2007-05-31

  An azole derivative of formula (I) a medicament that contains the azole derivative of formula (I), a method of treating a disease with the azole derivative of formula (I), and a method of preparing the azole derivative of formula (I).

  一种公式（I）的唑类衍生物药物，其中包含公式（I）的唑类衍生物，使用公式（I）的唑类衍生物治疗疾病的方法以及制备公式（I）的唑类衍生物的方法。
• Benzoxazole acetonitriles
  申请人：Schwarz Matthias

  公开号：US20070185104A1

  公开（公告）日：2007-08-09

  The present invention is related to benzoxazole acetonitriles as well as to pharmaceutical formulations containing such benzoxazole acetonitriles pof formula (I). Said benzoxazole acetonitriles are useful in the treatment of metabolic disorders mediated by insulin resistance or hyperglycemia, comprising diabetes type II, inadequate glucose tolerance, insulin resistance, obesity, polycystic ovary syndrome (PCOS). The present invention is furthermore related to methods of preparing benzoxazole acetonitriles (I). A is a pyrimidinyl.L is a secondary or tertiary amino group, or a 3-8 membered heterocycloalkyl, containing at least one heteroatom. selected from N, O, S or L is an acylamino moiety. R 1 is selected from the group comprising or consisting of hydrogen, sulfonyl, amino, C 1 C 6 -alkYl, C 2 -C 6 -alkenYl, C 2 -C 6 -alkynyl or C 1 -C 6 -alkoxy, aryl, halogen, carboxy, aminocarbonyl, cyano or hydroxy.

  本发明涉及苯并噁唑乙腈，以及含有该类苯并噁唑乙腈的制药配方(I)。所述苯并噁唑乙腈在治疗胰岛素抵抗或高血糖介导的代谢性疾病方面具有用途，包括2型糖尿病、不足的葡萄糖耐受性、胰岛素抵抗、肥胖症、多囊卵巢综合症（PCOS）。本发明还涉及制备苯并噁唑乙腈(I)的方法。其中A是吡咯啉基。L是一个次要或三级氨基团，或一个3-8个成员的杂环烷基，其中至少包含一个杂原子，选择自N、O、S，或L是一个酰胺基团。R1选择自氢、磺酰基、氨基、C1-C6-烷基、C2-C6-烯基、C2-C6-炔基或C1-C6-烷氧基、芳基、卤素、羧基、氨基甲酰基、氰基或羟基组成的群。
• AZOLE METHYLIDENE CYANIDE DERIVATIVES AND THEIR USE AS PROTEIN KINASE MODULATORS
  申请人：Applied Research Systems ARS Holding N.V.

  公开号：EP1527070A1

  公开（公告）日：2005-05-04