N-(4-氯苯基)-2-羟基-2-甲基丙酰胺 | 62100-41-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-(4-氯苯基)-2-羟基-2-甲基丙酰胺
• 英文名称: N-(4-Chlorphenyl)-2-hydroxi-2-methylpropionamid
• 英文别名: α-hydroxy-isobutyric acid-(4-chloro-anilide)；α-Hydroxy-isobuttersaeure-(4-chlor-anilid)；Propanamide, N-(4-chlorophenyl)-2-hydroxy-2-methyl-；N-(4-chlorophenyl)-2-hydroxy-2-methylpropanamide
• CAS: 62100-41-8
• 化学式: C₁₀H₁₂ClNO₂
• 分子量: 213.664
• InChiKey: ZCYXISYWYXCPNS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2924299090

反应信息

• 作为产物：
  描述：

  2-(4-氯苯氧基)-2-甲基丙酰胺 在 sodium hydride 作用下， 以 六甲基磷酰三胺 为溶剂， 生成 N-(4-氯苯基)-2-羟基-2-甲基丙酰胺
  参考文献：
  名称：

  A Smiles Rearrangement Involving Non-Activated Aromatic Systems; the Facile Conversion of Phenols to Anilines

  摘要：

  DOI：

  10.1055/s-1977-24263

文献信息

• Versatile synthesis of quaternary 1,3-oxazolidine-2,4-diones and their use in the preparation of α-hydroxyamides
  作者：Omar Merino、Blanca M. Santoyo、Luisa E. Montiel、Hugo A. Jiménez-Vázquez、L. Gerardo Zepeda、Joaquín Tamariz

  DOI：10.1016/j.tetlet.2010.05.034

  日期：2010.7

  A new approach to the synthesis of 1,3-oxazolidine-2,4-diones, via a two-step reaction sequence, starting from the readily available alpha-ketols and isocyanates, is reported. The condensation of the latter led to the key precursors 4-methylene-2-oxazolidinones, which are converted into the diones by an oxidative cleavage of the exocyclic double bond. Thus, 5,5-disubstituted 1,3-oxazolidine-2,4-diones can be accessed in good yields from the appropriate functionalized alpha-ketols. Moreover, two alternative routes are also described either by functionalization of 4-oxazolin-2-ones or by alkylation of the 1,3-oxazolidine-2,4-dione core previously prepared. Upon hydrolysis of the 1,3-oxazolidine-2,4-diones, a series of alpha-hydroxyamides bearing a quaternary stereocenter were obtained. (C) 2010 Elsevier Ltd. All rights reserved.
• α-Hydroxy Amides and Related Compounds
  作者：Seymour L. Shapiro、Ira M. Rose、Louis Freedman

  DOI：10.1021/ja01532a052

  日期：1959.12
• A Smiles Rearrangement Involving Non-Activated Aromatic Systems; the Facile Conversion of Phenols to Anilines
  作者：R. BAYLES、M. C. JOHNSON、R. F. MAISEY、R. W. TURNER

  DOI：10.1055/s-1977-24263

  日期：——
• Coutts, Ian G. C.; Southcott, Mark R., Journal of the Chemical Society. Perkin transactions I, 1990, p. 767 - 771
  作者：Coutts, Ian G. C.、Southcott, Mark R.

  DOI：——

  日期：——