4-chloro-N-[2-oxo-4-[(E)-2-phenylethenyl]-1,3-oxazolidin-3-yl]benzamide | 1354376-88-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-chloro-N-[2-oxo-4-[(E)-2-phenylethenyl]-1,3-oxazolidin-3-yl]benzamide
• CAS: 1354376-88-7
• 化学式: C₁₈H₁₅ClN₂O₃
• 分子量: 342.782
• InChiKey: PZTUWNKKMHVLGF-IZZDOVSWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-氯苯甲酰肼 在 三乙胺 作用下， 以 甲醇 、 二氯甲烷 、 六氟异丙醇 为溶剂， 反应 24.25h， 生成 4-chloro-N-[2-oxo-4-[(E)-2-phenylethenyl]-1,3-oxazolidin-3-yl]benzamide
  参考文献：
  名称：

  Petasis Three-Component Coupling Reactions of Hydrazides for the Synthesis of Oxadiazolones and Oxazolidinones

  摘要：

  An application of readily available hydrazides in the Petasis 3-component coupling reaction is presented. An investigation of the substrate scope was performed to establish a general, synthetically useful protocol for the formation of hydrazido alcohols, which were selectively converted to oxazolidinone and oxadiazolone ring systems through triphosgene-mediated cyclization reactions.

  DOI：

  10.1021/ol203280b

文献信息

• Petasis Three-Component Coupling Reactions of Hydrazides for the Synthesis of Oxadiazolones and Oxazolidinones
  作者：Sebastian T. Le Quement、Thomas Flagstad、Remi J. T. Mikkelsen、Mette R. Hansen、Michael C. Givskov、Thomas E. Nielsen

  DOI：10.1021/ol203280b

  日期：2012.1.20

  An application of readily available hydrazides in the Petasis 3-component coupling reaction is presented. An investigation of the substrate scope was performed to establish a general, synthetically useful protocol for the formation of hydrazido alcohols, which were selectively converted to oxazolidinone and oxadiazolone ring systems through triphosgene-mediated cyclization reactions.