苯甲酸阿普洛尔 | 67824-72-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 苯甲酸阿普洛尔
• 英文名称: Alprenolol benzoate
• 英文别名: benzoic acid;1-(propan-2-ylamino)-3-(2-prop-2-enylphenoxy)propan-2-ol
• CAS: 67824-72-0
• 化学式: C22H29NO4
• 分子量: 371.5
• InChiKey: URFIUJMADXJBKL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.54
• 重原子数：
  27
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  78.8
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Method and apparatus for granulation and granulated product
  申请人：WASHINGTON UNIVERSITY TECHNOLOGY ASSOCIATES, INC.

  公开号：EP0237345A2

  公开（公告）日：1987-09-16

  Method and apparatus for the formation of granules of a larger size or mass of a desired range from a feed stock (50) of smaller particles comprising feeding a meltable powdery material to be granulated, or a non-meltable powdery material with a meltable binder to the surface of a rotating spreader means (l0) in the form of a disk or bowl, at least a portion of which has been heated (l8) to a temperature above the melting point of the meltable compoent of the feed material wherein the rate of feeding, the energy input to the spreader means and the rotational speed of the spreader means are controlled so that there is sufficient time for at least a partial melting of the meltable component of the feed material substantially solely by contact with the heated surface of the spreader means, centrifugally spreading the material radially across the surface of the disk or bowl to form a layer of a liquid component (52) from the melted portion of the feed material on the surface of the spreader means, and dispersing the same from the edge thereof including droplets of the liquid component into an atomosphere cooler than the melting temperature to form the granulated product (54) in the cooler atmosphere. For certain materials only a part of the powdery feed material is melted forming a liquid film on the surface of the spreader means carrying a major portion of substantially unaffected or minimally affected feed material to produce a product comprising individual granules containing a core as the major part of each granule with the original powdery material essentially unchanged maintained in self-sustaining form by a matrix of melted and resolidified particles bonded to each other at their surface.

  从较小颗粒的给料(50)中形成所需范围的较大尺寸或质量的颗粒的方法和设备，包括将待造粒的可熔粉状材料或带有可熔粘合剂的不可熔粉状材料喂入圆盘或碗状的旋转撒料装置(l0)的表面，其中至少有一部分已被加热(l8)到高于给料材料可熔成分熔点的温度，其中喂料的速度、输入撒料装置的能量和撒料装置的旋转速度是可控的、对撒料装置的能量输入和撒料装置的转速进行控制，以便有足够的时间使进料中的可熔化成分至少部分熔化，这种熔化基本上完全是通过与撒料装置的加热表面接触实现的、在圆盘或碗的表面径向离心扩散物料，以便在撒布装置的表面上形成一层来自进料熔化部分的液体成分 (52)，并从其边缘将包括液体成分液滴在内的液体成分分散到比熔化温度更低的大气层中，以便在较低的大气层中形成颗粒状产品 (54)。对于某些物料，只有部分粉状进料被熔化，在撒料装置的表面形成一层液膜，携带大部分基本未受影响或受影响较小的进料，从而生产出一种产品，该产品由单个颗粒组成，每个颗粒的主要部分含有一个核心，原始粉状物料基本保持不变，由熔化和分解的颗粒基质在其表面相互粘合而成。
• NEW PHENOXYPROPANOLAMINE SALTS AND PHARMACEUTICAL PREPARATIONS THEREOF
  申请人：Aktiebolaget Hässle

  公开号：EP0209520A1

  公开（公告）日：1987-01-28
• JPH07206870A
  申请人：——

  公开号：JPH07206870A

  公开（公告）日：1995-08-08
• US5019302A
  申请人：——

  公开号：US5019302A

  公开（公告）日：1991-05-28
• [EN] NEW PHENOXYPROPANOLAMINE SALTS AND PHARMACEUTICAL PREPARATIONS THEREOF
  申请人：AKTIEBOLAGET HÄSSLE

  公开号：WO1985004579A1

  公开（公告）日：1985-10-24

  (EN) New salts of alprenolol useful in treatment of cardiac disorders are the salts with benzoic acid and maleic acid.(FR) De nouveaux sels d'alprénolol utiles pour le traitement d'affections cardiaques sont représentés par les sels formés d'acide benzoïque et d'acide maléique.