(5-formyl-2-hydroxy-3-methoxybenzyl)triphenylphosphonium chloride | 1225374-38-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (5-formyl-2-hydroxy-3-methoxybenzyl)triphenylphosphonium chloride
• 英文别名: (5-Formyl-2-hydroxy-3-methoxyphenyl)methyl-triphenylphosphanium;chloride
• CAS: 1225374-38-8
• 化学式: C₂₇H₂₄O₃P*Cl
• 分子量: 462.913
• InChiKey: FBLLPJYJNXLZBC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.71
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-methoxy-4-benzyloxybenzoyl chloride 、 (5-formyl-2-hydroxy-3-methoxybenzyl)triphenylphosphonium chloride 在 吡啶 、 三乙胺 作用下， 以 氯仿 为溶剂， 反应 8.0h， 以89%的产率得到2-(4-benzyloxy-3-methoxyphenyl)-7-methoxybenzo[b]furan-5-carboxaldehyde
  参考文献：
  名称：

  An expeditious and convergent synthesis of ailanthoidol

  摘要：

  An expeditious and concise method has been described for the synthesis of ailanthoidol through convergent route starting from vanillin. The protocol involving intramolecular Wittig as a key reaction afforded ailanthoidol in overall high yield. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.02.018
• 作为产物：
  描述：

  3-(氯甲基)-4-羟基-5-甲氧基苯甲醛 、 三苯基膦 以 甲苯 为溶剂， 反应 4.0h， 以95%的产率得到(5-formyl-2-hydroxy-3-methoxybenzyl)triphenylphosphonium chloride
  参考文献：
  名称：

  An expeditious and convergent synthesis of ailanthoidol

  摘要：

  An expeditious and concise method has been described for the synthesis of ailanthoidol through convergent route starting from vanillin. The protocol involving intramolecular Wittig as a key reaction afforded ailanthoidol in overall high yield. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.02.018

文献信息

• An expeditious and convergent synthesis of ailanthoidol
  作者：Maddali L.N. Rao、Dheeraj K. Awasthi、Debasis Banerjee

  DOI：10.1016/j.tetlet.2010.02.018

  日期：2010.4

  An expeditious and concise method has been described for the synthesis of ailanthoidol through convergent route starting from vanillin. The protocol involving intramolecular Wittig as a key reaction afforded ailanthoidol in overall high yield. (C) 2010 Elsevier Ltd. All rights reserved.