2-Methoxy-6-(3-methylphenyl)pyridine | 1096689-48-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-Methoxy-6-(3-methylphenyl)pyridine
• CAS: 1096689-48-3
• 化学式: C₁₃H₁₃NO
• 分子量: 199.252
• InChiKey: JCEJQNJBASTERF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  6-甲氧基吡啶-2-硼酸频哪醇酯 、 3-溴甲基苯 在 dichlorobis(chlorodi-tert-butylphosphine) palladium(II) 、 cesium fluoride 作用下， 以 丙醇 为溶剂， 反应 18.0h， 以42%的产率得到2-Methoxy-6-(3-methylphenyl)pyridine
  参考文献：
  名称：

  钯催化的Suzuki-Miyaura偶联的吡啶基-2-硼酸酯与芳基卤化物的偶合反应，使用的是高活性和空气稳定的氯化膦和氧化物配体

  摘要：

  吡啶基-2-硼酸酯的钯催化的Suzuki-Miyaura偶联为包含2-吡啶基部分的有用的联芳基结构单元提供了一种有效的方法。方便的反应方案证明了其在药物化学中的潜在广泛应用。

  DOI：

  10.1021/ol802642g

文献信息

• [EN] HETEROCYCLIC COMPOUNDS, IN PARTICULAR 2-OXO-4,4,5,5,6,6,7,7-OCTAHYDROBENZOXAZOLE DERIVATIVES, AND THEIR USE AS ANTIBACTERIAL COMPOUNDS<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES, EN PARTICULIER DÉRIVÉS DE 2-OXO -4,4,5,5,6,6,7,7-OCTAHYDROBENZOXAZOLE, ET LEUR UTILISATION EN TANT QUE COMPOSÉS ANTIBACTÉRIENS
  申请人：REDX PHARMA PLC

  公开号：WO2017137744A1

  公开（公告）日：2017-08-17

  This invention relates to antibacterial drug compounds containing a bicyclic core, typically a bicycle in which one of the rings is an oxazolidinone. It also relates to pharmaceutical formulations of antibacterial drug compounds. It also relates to uses of the compounds in treating bacterial infections and in methods of treating bacterial infections.

  这项发明涉及含有双环核心的抗菌药物化合物，通常是其中一个环是噁唑烷酮的双环。它还涉及抗菌药物化合物的药物配方。它还涉及化合物在治疗细菌感染和治疗细菌感染方法中的用途。
• [EN] ANTIBACTERIAL COMPOUNDS<br/>[FR] COMPOSÉS ANTIBACTÉRIENS
  申请人：REDX PHARMA PLC

  公开号：WO2017137743A1

  公开（公告）日：2017-08-17

  This invention relates to antibacterial drug compounds containing a bicyclic core, typically a bicycle in which one of the rings is an oxazolidinone. It also relates to pharmaceutical formulations of antibacterial drug compounds. It also relates to uses of the derivatives in treating bacterial infections and in methods of treating bacterial infections.

  该发明涉及含有双环核心的抗菌药物化合物，通常是其中一个环为噁唑烷酮的双环。它还涉及抗菌药物化合物的药物配方。它还涉及衍生物在治疗细菌感染和治疗细菌感染方法中的用途。
• [EN] SUBSTITUTED 3-HETEROAROYLAMINO-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS<br/>[FR] DÉRIVÉS SUBSTITUÉS DE L'ACIDE 3-HÉTÉROAROYLAMINO-PROPIONIQUE ET LEUR UTILISATION COMME COMPOSÉS PHARMACEUTIQUES
  申请人：SANOFI SA

  公开号：WO2012101197A1

  公开（公告）日：2012-08-02

  The present invention relates to compounds of the formula (I), wherein A, D, E, L, G, R10, R30, R40, R50 and R60 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. They are inhibitors of the protease cathepsin A, and are useful for the treatment of diseases such as atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.

  本发明涉及式(I)的化合物，其中A、D、E、L、G、R10、R30、R40、R50和R60具有所述权利要求中指示的含义，它们是有价值的药物活性化合物。它们是蛋白酶卡特普西A的抑制剂，可用于治疗动脉硬化、心力衰竭、肾脏疾病、肝脏疾病或炎症性疾病等疾病。本发明还涉及式(I)化合物的制备方法、它们的用途以及包含它们的药物组合物。
• SUBSTITUTED 3-HETEROAROYLAMINO-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS
  申请人：RUF Sven

  公开号：US20120252809A1

  公开（公告）日：2012-10-04

  The present invention relates to compounds of the formula I, wherein A, D, E, L, G, R 10 , R 30 , R 40 , R 50 and R 60 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. They are inhibitors of the protease cathepsin A, and are useful for the treatment of diseases such as atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.

  本发明涉及式I的化合物，其中A、D、E、L、G、R10、R30、R40、R50和R60具有声明中指示的含义，它们是有价值的药物活性化合物。它们是蛋白酶卡特普西林A的抑制剂，可用于治疗动脉硬化、心力衰竭、肾脏疾病、肝脏疾病或炎症性疾病等疾病。此外，本发明还涉及制备式I化合物的方法、它们的用途以及包含它们的制药组合物。
• US8669370B2
  申请人：——

  公开号：US8669370B2

  公开（公告）日：2014-03-11