8-methyl-2-(4-(trimethylsilyl)but-3-ynyl)-imidazo[1,2-a]pyridine | 872362-99-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 8-methyl-2-(4-(trimethylsilyl)but-3-ynyl)-imidazo[1,2-a]pyridine
• 英文别名: trimethyl-[4-(8-methylimidazo[1,2-a]pyridin-2-yl)but-1-ynyl]silane
• CAS: 872362-99-7
• 化学式: C₁₅H₂₀N₂Si
• 分子量: 256.423
• InChiKey: HFJMCARMNDEYNJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.46
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  17.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-(氯甲基)-8-甲基咪唑并[1,2-A]吡啶.HCL 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 2.5h， 以100%的产率得到8-methyl-2-(4-(trimethylsilyl)but-3-ynyl)-imidazo[1,2-a]pyridine
  参考文献：
  名称：

  [EN] ALKYNYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS
  [FR] NOUVEAUC DERIVES ALKYNYL SERVANT DE MODULATEURS DE RECEPTEURS DE GLUTAMATE METABOTROPIQUES

  摘要：

  公开号：

  WO2005123703A3

文献信息

• NOVEL ALKYNYL DERIVATIVES AS MODULATORS OF METATROPIC GLUTAMATE RECEPTORS
  申请人：Bessis Anne-Sophie

  公开号：US20090124625A1

  公开（公告）日：2009-05-14

  The present invention relates to novel compounds of formula (I) wherein W, n, X and W′ are defined in the description; invention compounds are modulators of metabotropic glutamate receptors—subtype 5 (“mGluR5”) which are useful for the treatment of central nervous system disorders as well as other disorders modulated by mGluR5 receptors.

  本发明涉及化合物的新型配方（I），其中W，n，X和W′在说明书中定义；发明的化合物是代谢型谷氨酸受体-亚型5（“mGluR5”）的调节剂，可用于治疗中枢神经系统疾病以及其他受mGluR5受体调节的疾病。
• Alkynyl derivatives as modulators of metatropic glutamate receptors
  申请人：Addex Pharma SA

  公开号：US08101637B2

  公开（公告）日：2012-01-24

  The present invention relates to novel compounds of formula (I) wherein W, n, X and W′ are defined in the description; invention compounds are modulators of metabotropic glutamate receptors-subtype 5 (“mGluR5”) which are useful for the treatment of central nervous system disorders as well as other disorders modulated by mGluR5 receptors.

  本发明涉及公式（I）的新化合物，其中W、n、X和W′在描述中有定义；发明的化合物是代谢型谷氨酸受体亚型5（“mGluR5”）的调节剂，可用于治疗中枢神经系统疾病以及其他受mGluR5受体调节的疾病。
• NOVEL ALKYNYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS
  申请人：Bessis Anne-Sophie

  公开号：US20120277237A1

  公开（公告）日：2012-11-01

  The present invention relates to novel compounds of formula I wherein W, n, X and W′ are defined in the description; invention compounds are modulators of metabotropic glutamate receptors—subtype 5 (“mGluR5”) which are useful for the treatment of central nervous system disorders as well as other disorders modulated by mGluR5 receptors.

  本发明涉及一种新型化合物，其化学式为I，其中W、n、X和W′在说明中有定义；发明化合物是代谢型谷氨酸受体-亚型5（“mGluR5”）的调节剂，可用于治疗中枢神经系统疾病以及其他受mGluR5受体调节的疾病。
• Alkynyl derivatives as modulators of metabotropic glutamate receptors
  申请人：Bonnet Béatrice

  公开号：US08674106B2

  公开（公告）日：2014-03-18

  The present invention relates to novel compounds of formula I wherein W, n, X and W′ are defined in the description; invention compounds are modulators of metabotropic glutamate receptors—subtype 5 (“mGluR5”) which are useful for the treatment of central nervous system disorders as well as other disorders modulated by mGluR5 receptors.

  本发明涉及公式I的新化合物，其中W、n、X和W'在说明中定义；发明化合物是代谢型谷氨酸受体亚型5（“mGluR5”）的调节剂，可用于治疗中枢神经系统疾病以及其他受mGluR5受体调节的疾病。
• [EN] ALKYNYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS<br/>[FR] NOUVEAUC DERIVES ALKYNYL SERVANT DE MODULATEURS DE RECEPTEURS DE GLUTAMATE METABOTROPIQUES
  申请人：ADDEX PHARMACEUTICALS SA

  公开号：WO2005123703A3

  公开（公告）日：2006-10-12