4-chloro-N'-methyl-N'-methylsulfonylbenzenesulfonohydrazide | 110295-67-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-chloro-N'-methyl-N'-methylsulfonylbenzenesulfonohydrazide
• CAS: 110295-67-5
• 化学式: C₈H₁₁ClN₂O₄S₂
• 分子量: 298.771
• InChiKey: DFGHNOYFHSUGMU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  100
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  methanesulfonic acid 1-methylhydrazide 、 4-氯苯磺酰氯 在 吡啶 作用下， 以28%的产率得到4-chloro-N'-methyl-N'-methylsulfonylbenzenesulfonohydrazide
  参考文献：
  名称：

  1,2-Bis(sulfonyl)hydrazines. 3. Effects of structural modification on antineoplastic activity

  摘要：

  A series of 1,2-bis(sulfonyl)hydrazines was synthesized and evaluated for antineoplastic activity against the L1210 leukemia and the B16 melanoma. The most active agent to emerge from this study, 1,2-bis(methylsulfonyl)-1-methylhydrazine, produced a maximum % T/C for mice bearing the L1210 leukemia or the B16 melanoma of 340% and 278%, respectively. Two N-chloroethyl analogues, conceived as bifunctional alkylating agents, were also synthesized and evaluated for antineoplastic activity against the L1210 leukemia and the B16 melanoma. Although such a modification resulted in retention of antineoplastic activity against both tumor cell lines, it did not result in enhanced antineoplastic activity.

  DOI：

  10.1021/jm00394a040

文献信息

• Novel, N,N'bis(sulfonyl) hydrazines having antineoplastic activity
  申请人：YALE UNIVERSITY

  公开号：EP0185387A1

  公开（公告）日：1986-06-25

  Compounds of the formula where R is methyl or 2-chloroethyl, and R' and R2 are each an aromatic hydrocarbon, ring substituted aromatic hydrocarbon moiety, or an alkyl moiety. The compounds have been found to be alkylating agents having antineoplastic activity.

  式中 R 为甲基或 2-氯乙基，R'和 R2 分别为芳香烃、环取代芳香烃分子或烷基分子的化合物。 这些化合物是具有抗肿瘤活性的烷基化剂。
• SHYAM, KRISHNAMURTHY;HRUBIEC, ROBERT T.;FURUBAYASHI, RYOSUKE;COSBY, LUCIL+, J. MED. CHEM., 30,(1987) N 11, 2157-2161
  作者：SHYAM, KRISHNAMURTHY、HRUBIEC, ROBERT T.、FURUBAYASHI, RYOSUKE、COSBY, LUCIL+

  DOI：——

  日期：——