bis(6-bromo-2-pyridyl)(phenyl)phosphane | 68469-72-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: bis(6-bromo-2-pyridyl)(phenyl)phosphane
• 英文别名: Pyridine, 2,2'-(phenylphosphinidene)bis[6-bromo-；bis(6-bromopyridin-2-yl)-phenylphosphane
• CAS: 68469-72-7
• 化学式: C₁₆H₁₁Br₂N₂P
• 分子量: 422.058
• InChiKey: KRPBXLXCYRLSRK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(2-pyridyl)pyrimidine 、 bis(6-bromo-2-pyridyl)(phenyl)phosphane 在 正丁基锂 作用下， 以 乙醚 、 正己烷 为溶剂， 以26%的产率得到4-(6-phenyl-2-pyridyl)-6-(2-pyridyl)pyrimidine
  参考文献：
  名称：

  Kraemer, R.; Fritsky, Igor O., European Journal of Organic Chemistry, 2000, # 20, p. 3505 - 3510

  摘要：

  DOI：
• 作为产物：
  描述：

  2-(6-bromopyridinyl)lithium 、 苯基二氯化磷 以 乙醚 为溶剂， 反应 0.5h， 以78%的产率得到bis(6-bromo-2-pyridyl)(phenyl)phosphane
  参考文献：
  名称：

  Kraemer, R.; Fritsky, Igor O., European Journal of Organic Chemistry, 2000, # 20, p. 3505 - 3510

  摘要：

  DOI：

文献信息

• Carbonylation catalyst system
  申请人：SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V.

  公开号：EP0386833A1

  公开（公告）日：1990-09-12

  A catalyst system, which comprises a) a source of a Group VIII metal, and b) a phosphine of general formula: in which R¹, R² and R³ are independently selected from an optionally substituted aryl group and a group of general formula: wherein each of A, X, Y and Z is independently selected from a nitrogen atom, a CH group and a group of formula CR wherein R represents a hydroxyl group, an amino group, an amido group, a cyano group, an aryl group, an aryloxy group, a halogen atom, an optionally substitut­ed hydrocarbyl group or an optionally substituted hydrocarbyloxy group, it also being possible for two adjacent CR groups to form a ring, provided that at least one of R¹, R² and R³ represents a group of formu­la (II) in which at least one of A and Z represents a group of formula CR; or an acid addition salt thereof. Also disclosed are novel phosphines, and the use of the catalyst system in the selective carbonylation of unsaturated hydrocarbons.

  催化剂系统，包括 a) 第 VIII 族金属源，和 b) 通式为 其中 R¹、R² 和 R³ 分别独立地选自任选取代的芳基和通式如下的基团： 其中 A、X、Y 和 Z 各自独立地选自一个氮原子、一个 CH 基团和一个通式为 CR 的基团，其中 R 代表羟基、氨基、酰胺基、氰基、芳基、芳氧基、卤素原子、任选取代的烃基或任选取代的烃氧基，相邻的两个 CR 基团也可以形成一个环，条件是 R¹、R² 和 R³ 中至少有一个代表式 (II) 的基团，其中 A 和 Z 中至少有一个代表式 CR 的基团；或其酸加成盐。 此外，还公开了新型膦以及该催化剂体系在不饱和烃选择性羰基化中的用途。
• Preparation of amides
  申请人：SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V.

  公开号：EP0441445A2

  公开（公告）日：1991-08-14

  A process for the preparation of an amide, which comprises reacting an acetylenically or olefinically unsaturated compound with carbon monoxide and a nitrogen compound selected from ammonia and a primary or secondary amine or amide, in the presence of a catalyst system which comprises: a) a source of a Group VIII metal, b) a phosphine having an aromatic substituent which contains an imino nitrogen atom, and c) a protonic acid.

  一种制备酰胺的工艺，包括在催化剂体系存在下，使乙炔或烯烃不饱和化合物与一氧化碳和一种选自氨和伯胺或仲胺或酰胺的氮化合物反应，该催化剂体系包括 a) 第 VIII 族金属源、 b) 具有包含亚氨基氮原子的芳香取代基的膦，以及 c) 质子酸。
• Catalytic systems and methods for carbonylation
  申请人：DAICEL CHEMICAL INDUSTRIES CO., LTD.

  公开号：EP0696474A2

  公开（公告）日：1996-02-14

  A carbonylation catalytic system comprises (A) a combination of (A1) a Group VIII metal source of Periodic Table of the Elements (e.g., palladium, palladium chloride) supported on a carrier, (A2) a ligand such as triphenylphosphine and (A3) an acid such as an alkyl-sulfonic acid, or (B) a combination of (B1) the Group VIII metal source except for palladium (e.g., a platinum compound), (B2) a ligand such as triphenylphosphine and (B3) an electron donative compound having an electron donability ΔνD of not less than 2 (for instance, an amine such as a heterocyclic tertiary amine). The catalytic system (B) may further comprise (B4) an acid such as methanesulfonic acid. In the presence of the catalytic system (A) or (B), an acetylenic or olefinic unsaturated compound is allowed to react with carbon monoxide and a nucleophilic compound having an active hydrogen such as water, an alcohol and a carboxylic acid in a liquid phase to give an unsaturated or saturated carboxylic acid or an ester thereof with high transformation rate and selectivity.

  一种羰基化催化体系包括(A) (A1)支撑在载体上的元素周期表第八族金属源（如钯、氯化钯）、(A2)配体（如三苯基膦）和(A3)酸（如烷基磺酸）的组合，或(B) (B1)除钯以外的第八族金属源（如铂化合物）、(B2)配体（如三苯基膦）和(B3)电子捐献化合物（电子捐献率ΔνD不小于2实例）的组合、铂化合物）、(B2) 三苯基膦等配体和 (B3) 电子捐赠性 ΔνD 不小于 2 的电子捐赠化合物（例如，杂环叔胺等胺）的组合。催化体系 (B) 可进一步包括 (B4) 酸，如甲磺酸。在催化体系（A）或（B）的存在下，乙炔基或烯烃基不饱和化合物可与一氧化碳和具有活泼氢的亲核化合物（如水、醇和羧酸）在液相中发生反应，以高转化率和高选择性得到不饱和或饱和羧酸或其酯。
• Catalytic systems and method for carbonylation
  申请人：DAICEL CHEMICAL INDUSTRIES, LTD.

  公开号：EP0948999A1

  公开（公告）日：1999-10-13

  A carbonylation catalytic system comprises (B) a combination of (B1) the Group VIII metal source except for palladium (e.g., a platinum compound), (B2) a ligand such as triphenylphosphine and (B3) an electron donative compound having an electron donability ΔνD of not less than 2 (for instance, an amine such as a heterocyclic tertiary amine). The catalytic system (B) may further comprise (B4) an acid such as methanesulfonic acid. In the presence of the catalytic system (B), an acetylenic or olefinic unsaturated compound is allowed to react with carbon monoxide and a nucleophilic compound having an active hydrogen such as water, an alcohol and a carboxylic acid in a liquid phase to give an unsaturated or saturated carboxylic acid or an ester thereof with high transformation rate and selectivity.

  羰基化催化体系包括(B)(B1)除钯以外的第八族金属源（如铂化合物）、(B2)配体（如三苯基膦）和(B3)电子捐赠性ΔνD不小于2的电子捐赠性化合物（例如胺，如杂环叔胺）的组合。催化体系 (B) 可进一步包括 (B4) 酸，如甲磺酸。在催化体系（B）存在的情况下，乙炔或烯烃类不饱和化合物可与一氧化碳和具有活泼氢的亲核化合物（如水、醇和羧酸）在液相中发生反应，从而以较高的转化率和选择性得到不饱和或饱和羧酸或其酯。
• Carbonylation catalyst process
  申请人：SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V.

  公开号：EP0441447B1

  公开（公告）日：1994-11-30