4-isopropoxy-N-isopropylbenzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-isopropoxy-N-isopropylbenzamide
• 英文别名: N-propan-2-yl-4-propan-2-yloxybenzamide
• 化学式: C₁₃H₁₉NO₂
• mdl: MFCD07139365
• 分子量: 221.29
• InChiKey: QBAMFMWYHKHRLV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.461
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• DEGRADABLE POLYMERS OF A CYCLIC SILYL ETHER AND USES THEREOF
  申请人：Massachusetts Institute of Technology

  公开号：US20200055879A1

  公开（公告）日：2020-02-20

  The present disclosure provides cyclic silyl ethers of the formula: and salts thereof. The cyclic silyl ethers may be useful as monomers for preparing polymers. Also described herein are polymers prepared by polymerizing a cyclic silyl ether and optionally one or more additional monomers. The polymers may be degradable (e.g., biodegradable). One or more O—Si bonds of the polymers may be the degradation sites. Also described herein are compositions and kits including the cyclic silyl ethers or polymers; methods of preparing the polymers; and methods of using the polymers, compositions, and kits.

  本公开提供了下述结构的环状硅醚及其盐。这些环状硅醚可能用作制备聚合物的单体。本文还描述了通过聚合环状硅醚以及可选地使用一个或多个额外单体制备的聚合物。这些聚合物可能是可降解的（例如，生物降解的）。聚合物的一个或多个O—Si键可能是降解位点。本文还描述了包括环状硅醚或聚合物的组合物和套装；制备聚合物的方法；以及使用聚合物、组合物和套装的方法。
• Benzimidazole derivatives
  申请人：Enanta Pharmaceuticals, Inc.

  公开号：US10017499B2

  公开（公告）日：2018-07-10

  The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

  本发明公开了式（I）化合物或其药学上可接受的盐、酯或原药： 它们能抑制含 RNA 的病毒，特别是丙型肝炎病毒（HCV）。因此，本发明的化合物可干扰丙型肝炎病毒的生命周期，也可用作抗病毒药物。本发明进一步涉及包含上述化合物的药物组合物，用于给丙型肝炎病毒感染者用药。本发明还涉及通过施用包含本发明化合物的药物组合物治疗受试者感染 HCV 的方法。
• Branched multi-functional macromonomers and uses thereof
  申请人：Massachusetts Institute of Technology

  公开号：US10716858B2

  公开（公告）日：2020-07-21

  Disclosed are methods, compositions, reagents, systems, and kits to prepare and utilize branched multi-functional macromonomers, which contain a ring-opening metathesis polymerizable norbornene group, one or more reactive sites capable of undergoing click chemistry, and a terminal acyl group capable of undergoing a coupling reaction; branched multi-cargo macromonomers; and the corresponding polymers are disclosed herein. Various embodiments show that the macromonomers and polymers disclosed herein display unprecedented control of cargo loading of agents. These materials have the potential to be utilized for the treatment of diseases and conditions such as cancer and hypertension.

  本文公开了制备和利用支化多功能大单体的方法、组合物、试剂、系统和试剂盒，支化多功能大单体含有可开环偏聚的降冰片烯基、一个或多个可进行点击化学反应的反应位点和一个可进行偶联反应的末端酰基；本文公开了支化多载体大单体和相应的聚合物。各种实施方案表明，本文所公开的大单体和聚合物可对药剂的负载进行前所未有的控制。这些材料有望用于治疗癌症和高血压等疾病。
• Degradable polymers of a cyclic silyl ether and uses thereof
  申请人：Massachusetts Institute of Technology

  公开号：US10988491B2

  公开（公告）日：2021-04-27

  The present disclosure provides cyclic silyl ethers of the formula: and salts thereof. The cyclic silyl ethers may be useful as monomers for preparing polymers. Also described herein are polymers prepared by polymerizing a cyclic silyl ether and optionally one or more additional monomers. The polymers may be degradable (e.g., biodegradable). One or more O—Si bonds of the polymers may be the degradation sites. Also described herein are compositions and kits including the cyclic silyl ethers or polymers; methods of preparing the polymers; and methods of using the polymers, compositions, and kits.

  本公开提供了式中的环状硅基醚： 及其盐类。环硅烷醚可用作制备聚合物的单体。本文还描述了通过聚合环硅烷醚和一种或多种附加单体制备的聚合物。这些聚合物可以降解（如可生物降解）。聚合物的一个或多个 O-Si 键可以是降解位点。本文还描述了包括环硅烷醚或聚合物的组合物和试剂盒；制备聚合物的方法；以及使用聚合物、组合物和试剂盒的方法。
• NOVEL BENZIMIDAZOLE DERIVATIVES
  申请人：Qiu Yao-Ling

  公开号：US20100233122A1

  公开（公告）日：2010-09-16

  The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.