7-benzyloxy-4-methyl-benzo[h]chromen-2-one | 1231948-23-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并吡喃类
• 英文名称: 7-benzyloxy-4-methyl-benzo[h]chromen-2-one
• 英文别名: 4-Methyl-7-phenylmethoxybenzo[h]chromen-2-one
• CAS: 1231948-23-4
• 化学式: C₂₁H₁₆O₃
• 分子量: 316.356
• InChiKey: DRZOFBSFLPPFOI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-甲基-7-羟基-8-硝基香豆素 、 溴甲苯 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以68%的产率得到7-benzyloxy-4-methyl-benzo[h]chromen-2-one
  参考文献：
  名称：

  Synthesis of novel benzocoumarin derivatives as lipid lowering agents

  摘要：

  A series of novel benzocoumarin derivatives were synthesized and evaluated for their in vivo anti-dyslipidemic and in vitro antioxidant activities. Preliminary screening indicates compound 4 as potential lead with significant lipid lowering and antioxidant activities. The study revealed that such attempts on benzocoumarin-based pharmacophores which is a biologically important scaffold might result in identification of new lead for anti-dyslipidemia. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.03.103

文献信息

• Synthesis of novel benzocoumarin derivatives as lipid lowering agents
  作者：Koneni V. Sashidhara、Jammikuntla N. Rosaiah、Abdhesh Kumar、Gitika Bhatia、A.K. Khanna

  DOI：10.1016/j.bmcl.2010.03.103

  日期：2010.5

  A series of novel benzocoumarin derivatives were synthesized and evaluated for their in vivo anti-dyslipidemic and in vitro antioxidant activities. Preliminary screening indicates compound 4 as potential lead with significant lipid lowering and antioxidant activities. The study revealed that such attempts on benzocoumarin-based pharmacophores which is a biologically important scaffold might result in identification of new lead for anti-dyslipidemia. (C) 2010 Elsevier Ltd. All rights reserved.