2-(3-(3-(trifluoromethyl)phenyl)but-3-enyl)isoindoline-1,3-dione | 1229971-66-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-(3-(3-(trifluoromethyl)phenyl)but-3-enyl)isoindoline-1,3-dione
• 英文别名: 2-[3-[3-(Trifluoromethyl)phenyl]but-3-enyl]isoindole-1,3-dione；2-[3-[3-(trifluoromethyl)phenyl]but-3-enyl]isoindole-1,3-dione
• CAS: 1229971-66-7
• 化学式: C₁₉H₁₄F₃NO₂
• 分子量: 345.321
• InChiKey: AWCHEWFSGPFMHW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  间溴三氟甲苯 、 2-(3-(dimethyl(perfluorophenyl)silyl)but-3-enyl)isoindoline-1,3-dione 在 四丁基氟化铵 、 bis(dibenzylideneacetone)-palladium⁽⁰⁾ 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 生成 2-(3-(3-(trifluoromethyl)phenyl)but-3-enyl)isoindoline-1,3-dione
  参考文献：
  名称：

  Diversity-Oriented Synthesis of Disubstituted Alkenes Using Masked Silanols

  摘要：

  The regio- and stereoselective synthesis and subsequent Hiyama cross coupling of pentafluorophenyldimethylvinylsilanes has been developed, thus providing a convenient and robust method for the diversity-oriented synthesis of (E)-, (Z)- and alpha-disubstituted alkenes from terminal alkynes. Pentafluorophenyldimethylvinylsilanes undergo cross-coupling reactions with excellent selectivity and in good yields, offering an attractive alternative to existing masked silanols.

  DOI：

  10.1021/ol100895d

文献信息

• Diversity-Oriented Synthesis of Disubstituted Alkenes Using Masked Silanols
  作者：Hannah F. Sore、David T. Blackwell、Simon J. F. MacDonald、David R. Spring

  DOI：10.1021/ol100895d

  日期：2010.6.18

  The regio- and stereoselective synthesis and subsequent Hiyama cross coupling of pentafluorophenyldimethylvinylsilanes has been developed, thus providing a convenient and robust method for the diversity-oriented synthesis of (E)-, (Z)- and alpha-disubstituted alkenes from terminal alkynes. Pentafluorophenyldimethylvinylsilanes undergo cross-coupling reactions with excellent selectivity and in good yields, offering an attractive alternative to existing masked silanols.