ethyl 6-methoxy-7-methylchromone-2-carboxylate | 630390-76-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: ethyl 6-methoxy-7-methylchromone-2-carboxylate
• 英文别名: Ethyl 6-methoxy-7-methyl-4-oxochromene-2-carboxylate；ethyl 6-methoxy-7-methyl-4-oxochromene-2-carboxylate
• CAS: 630390-76-0
• 化学式: C₁₄H₁₄O₅
• 分子量: 262.262
• InChiKey: FDKGLAQHRFBTDC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  ethyl 6-methoxy-7-methylchromone-2-carboxylate 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 生成 4-Hydroxy-6-methoxy-7-methyl-chroman-2-carboxylic acid ethyl ester
  参考文献：
  名称：

  Synthesis of O-methyl epi-heliannuol E

  摘要：

  A synthesis of the methyl ether of an epimer of the alleochemical heliannuol E is described. The route involves indium mediated allylation of a benzopyranone carboxylate and subsequent one carbon degradation to a vinyl group. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2003.08.059
• 作为产物：
  描述：

  1-(2,5-dihydroxy-4-methylphenyl)ethanone 在 sodium hydride 、 potassium carbonate 作用下， 以 四氢呋喃 、 丙酮 为溶剂， 反应 14.0h， 生成 ethyl 6-methoxy-7-methylchromone-2-carboxylate
  参考文献：
  名称：

  Synthesis of O-methyl epi-heliannuol E

  摘要：

  A synthesis of the methyl ether of an epimer of the alleochemical heliannuol E is described. The route involves indium mediated allylation of a benzopyranone carboxylate and subsequent one carbon degradation to a vinyl group. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2003.08.059

文献信息

• Synthesis of O-methyl epi-heliannuol E
  作者：Subir Kumar Sabui、Ramanathapuram V Venkateswaran

  DOI：10.1016/j.tet.2003.08.059

  日期：2003.10

  A synthesis of the methyl ether of an epimer of the alleochemical heliannuol E is described. The route involves indium mediated allylation of a benzopyranone carboxylate and subsequent one carbon degradation to a vinyl group. (C) 2003 Elsevier Ltd. All rights reserved.