4,4'-(1,3,4-thiadiazole-2,5-diyl)bis(N,N-dimethylaniline) | 2642-60-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4,4'-(1,3,4-thiadiazole-2,5-diyl)bis(N,N-dimethylaniline)
• 英文别名: 2,5-Bis(4-dimethylaminophenyl)-1,3,4-thiadiazole；4-[5-[4-(dimethylamino)phenyl]-1,3,4-thiadiazol-2-yl]-N,N-dimethylaniline
• CAS: 2642-60-6
• 化学式: C₁₈H₂₀N₄S
• 分子量: 324.45
• InChiKey: IALWZQQVWRYQIK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  60.5
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4,4'-(1E,1'E)-hydrazine-1,2-diylidenebis(methan-1-yl-1-ylidene)bis(N,N-dimethylaniline) 在 sulfur 作用下， 以95%的产率得到4,4'-(1,3,4-thiadiazole-2,5-diyl)bis(N,N-dimethylaniline)
  参考文献：
  名称：

  Solvent-Free Green Synthesis of Azines and Their Conversion to 2,5-Disubstituted-1,3,4-thiadiazoles

  摘要：

  A solvent-free, clean, and efficient method has been developed for the synthesis of 2,5-disubstituted-1,3,4-thiadiazoles via azines. This approach exploits the synthetic potential of clean reactions and offers many advantages such as excellent product yields, easy isolation of products, and ecofriendly benign reaction conditions. The newly synthesized compounds were analyzed by infrared, H-1 NMR, C-13 NMR, and elemental analysis.

  DOI：

  10.1080/00397911.2015.1113297

文献信息

• Rapid synthesis of 2,5-disubtituted 1,3,4-thiadiazoles under microwave irradiation
  作者：Mounim Lebrini、Fouad Bentiss、Michel Lagrenée

  DOI：10.1002/jhet.5570420538

  日期：2005.7

  The one pot, three-components condensation of aromatic aldehydes, hydrazine and sulfur in ethanol under microwave irradiation provided symmetrically 3,5-disubstituted 1,3,4-thiadiazoles in high yields and good purity. This reaction must be conducted under pressure of hydrogen sulfide produced in-situ. The structure of the compounds was confirmed by 1H, 13C NMR, MS and elemental analysis.

  在微波辐射下，一锅三组分的芳香醛，肼和硫在乙醇中的缩合反应可对称地提供3,5-二取代的1,3,4-噻二唑，产率高且纯度高。该反应必须在原位产生的硫化氢的压力下进行。化合物的结构通过1 H，13 C NMR，MS和元素分析确认。
• Pharmaceutical composition containing aminopteridines or aminopyrimido(4,5-d)pyrimidines
  申请人：Smith and Nephew Associated Companies p.l.c.

  公开号：EP0059524A1

  公开（公告）日：1982-09-08

  A sterile, non-irritant, non toxic pharmaceutical composition adapted for topical administration to the eye is described which contains a compound of formula (I): wherein X = Y is CR = N or N = CR where at least two of R, R', R2 and R3 are amino groups and the other groups of R, R', R2 and R3 are hydrogen atom, lower alkyl, aryl, carboxamido or lower alkoxycarbonyl groups except that when R', R2 and R3 are all amino and X = Y is CR = N, R is not phenyl. The composition may be used to treat ocular hypertension and glaucoma.

  本发明描述了一种无菌、无刺激、无毒、适用于眼部局部用药的药物组合物，该组合物含有式 (I) 的化合物： 其中 X = Y 为 CR = N 或 N = CR，其中 R、R'、R2 和 R3 中至少有两个基团为氨基，R、R'、R2 和 R3 中的其他基团为氢原子、低级烷基、芳基、羧酰胺基或低级烷氧羰基，但当 R'、R2 和 R3 均为氨基且 X = Y 为 CR = N 时，R 不是苯基。该组合物可用于治疗眼压过高和青光眼。
• Photopolymerizable composition
  申请人：MITSUBISHI KASEI CORPORATION

  公开号：EP0138187A2

  公开（公告）日：1985-04-24

  A photopolymerizable composition comprising an addition-polymerizable compound having at least one ethylenically unsaturated double bond and a photopolymerization initiator, characterized in that the initiator comprises (a) a compound of the formula: wherein R1 and R2 are alkyl group, n is 1, 2 or 3 and ring A is an aromatic ring containing nitrogen atom, and (b) hexaarylbiimidazole. The initiator may additionally contain a thiol of the formula: wherein Z is -0-, -S- or -NH-. The composition is not only highly sensitive to ultraviolet ray but also highly stable in storage.

  一种可光聚合的组合物，包括至少有一个乙烯不饱和双键的可加成聚合的化合物和一种光聚合引发剂，其特征在于引发剂包括(a)式中R1和R2为烷基，n为1、2或3，环A为含氮原子的芳香环的化合物，和(b)六芳基比咪唑。 引发剂还可含有式中Z为-0-、-S-或-NH-的硫醇。 该组合物不仅对紫外线高度敏感，而且在储存中高度稳定。
• Mazzone, Gioacchino; Puglisi, Giovanni; Bonina, Francesco, Journal of Heterocyclic Chemistry, 1983, vol. 20, p. 1399 - 1401
  作者：Mazzone, Gioacchino、Puglisi, Giovanni、Bonina, Francesco、Corsaro, Antonino

  DOI：——

  日期：——
• MAZZONE, G.;PUGLISI, G.;BONINA, F.;CORSARO, A., J. HETEROCYCL. CHEM., 1983, 20, N 5, 1399-1401
  作者：MAZZONE, G.、PUGLISI, G.、BONINA, F.、CORSARO, A.

  DOI：——

  日期：——