p-((dimethylamino)benzylidene)semicarbazide | 2929-82-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: p-((dimethylamino)benzylidene)semicarbazide
• 英文别名: (E)-2-(4-(dimethylamino)benzylidene)hydrazine carboxamide；p-dimethylaminobenzaldehyde semicarbazone；4-(Dimethylamino)benzaldehyde, semicarbazone；[(E)-[4-(dimethylamino)phenyl]methylideneamino]urea
• CAS: 2929-82-0
• 化学式: C₁₀H₁₄N₄O
• 分子量: 206.247
• InChiKey: NMHVBJBGCKBVDH-KPKJPENVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  70.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  p-((dimethylamino)benzylidene)semicarbazide 以90%的产率得到4,4'-(1E,1'E)-hydrazine-1,2-diylidenebis(methan-1-yl-1-ylidene)bis(N,N-dimethylaniline)
  参考文献：
  名称：

  Solvent-Free Green Synthesis of Azines and Their Conversion to 2,5-Disubstituted-1,3,4-thiadiazoles

  摘要：

  A solvent-free, clean, and efficient method has been developed for the synthesis of 2,5-disubstituted-1,3,4-thiadiazoles via azines. This approach exploits the synthetic potential of clean reactions and offers many advantages such as excellent product yields, easy isolation of products, and ecofriendly benign reaction conditions. The newly synthesized compounds were analyzed by infrared, H-1 NMR, C-13 NMR, and elemental analysis.

  DOI：

  10.1080/00397911.2015.1113297
• 作为产物：
  描述：

  diethyl p-(N,N'-dimethylamino)-benzylidenemalonate 、 S-(4-叔-丁基苯甲基)[2-(1-甲基丁基)吡啶-3-基]硫代氨基甲酸酯 以71%的产率得到
  参考文献：
  名称：

  MOHAMED M. M.; EL HASHASH M. A.; EL KADY M. Y.; HASSAN M. A., REV. ROUM. CHIM., 1980, 25, NO 2, 237-244

  摘要：

  DOI：

文献信息

• ALTURAL, BEHZAT;AKCAMUR, YUNUS;SARIPINAR, EMIN;YILDIRIM, ISMAIL;KOLLENZ, +, MONATSH. CHEM., 120,(1989) N1, C. 1015-1020
  作者：ALTURAL, BEHZAT、AKCAMUR, YUNUS、SARIPINAR, EMIN、YILDIRIM, ISMAIL、KOLLENZ, +

  DOI：——

  日期：——
• BANSAL, R. K.;BHAGCHANDANI, G., J. INDIAN CHEM. SOC., 1982, 59, N 2, 277-279
  作者：BANSAL, R. K.、BHAGCHANDANI, G.

  DOI：——

  日期：——
• P-Dimethylaminobenzaldehyde semicarbazone: The bonding abilities of imine nitrogen atom
  作者：Agata Trzesowska

  DOI：10.1016/j.molstruc.2008.07.004

  日期：2009.1

  The crystal and molecular structures of p-dimethylaminobenzaldehyde semicarbazone and p-dimethylaminobenzaldehyde semicarbazone hydrochloride have been determined. On the basis of quantum-mechanical calculations the availability of the imine nitrogen atom for bonding with molecular species was analysed and also the complete assignment of the experimental IR spectrum was performed. The p-dimethylaminobenzaldehyde semicarbazone was characterised by thermogravimetric analysis in conjunction with evolved gases in the air atmosphere. (c) 2008 Elsevier B.V. All rights reserved.
• HEME OXYGENASE INHIBITORS, SCREENING METHODS FOR HEME OXYGENASE INHIBITORS AND METHODS OF USE OF HEME OXYGENASE INHIBITORS FOR ANTIMICROBIAL THERAPY
  申请人：Wilks Angela

  公开号：US20100081661A1

  公开（公告）日：2010-04-01

  Inhibitors of microbial heme oxygenase and their use for treatment of microbial infections and bioremediation. The inhibitors of microbial heme oxygenase are useful against a new class of antimicrobial agents to target infections that are persistently difficult to combat with the current spectrum of antimicrobial agents. Screening methods for selecting inhibitors of microbial heme oxygenase.