(E)-3-anthracen-9-yl-N-(hydroxycarbamoylphenylmethyl)acrylamide | 1384254-50-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: (E)-3-anthracen-9-yl-N-(hydroxycarbamoylphenylmethyl)acrylamide
• 英文别名: (E)-3-anthracen-9-yl-N-[2-(hydroxyamino)-2-oxo-1-phenylethyl]prop-2-enamide
• CAS: 1384254-50-5
• 化学式: C₂₅H₂₀N₂O₃
• 分子量: 396.445
• InChiKey: UFCVJYSREUYUDT-CCEZHUSRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  78.4
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (E)-3-(anthracen-9-yl)acryloyl chloride 在 盐酸羟胺 、 三乙胺 、 potassium hydroxide 作用下， 以 1,4-二氧六环 、 甲醇 、 二氯甲烷 为溶剂， 反应 1.5h， 生成 (E)-3-anthracen-9-yl-N-(hydroxycarbamoylphenylmethyl)acrylamide
  参考文献：
  名称：

  Photoinduced DNA cleavage by anthracene based hydroxamic acids

  摘要：

  Two different series of naphthalene and anthracene based hydroxamic acids having amino acid derivatives were synthesized. Single strand DNA cleavage was achieved on irradiation of newly synthesized hydroxamic acids by UV light (>= 350 nm). Both reactive oxygen species (ROS) and generated radicals from hydroxamic acids were shown to be responsible for the DNA cleavage. Further, DNA cleaving ability of hydroxamic acids was found to be dependent on its concentration and on its structure. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.05.084