3-(azepan-1-ylsulfonyl)-N-(1,3-benzodioxol-5-yl)benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(azepan-1-ylsulfonyl)-N-(1,3-benzodioxol-5-yl)benzamide
• 化学式: C₂₀H₂₂N₂O₅S
• 分子量: 402.5
• InChiKey: MZFJPPSXAWDWFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  93.3
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• COMPOSITIONS AND METHODS FOR MODULATING SIRTUIN ACTIVITY
  申请人：The General Hospital Corporation

  公开号：EP2068875A2

  公开（公告）日：2009-06-17
• Compositions and methods for modulating sirtuin activity
  申请人：Kazantsev Aleksey G.

  公开号：US20080021063A1

  公开（公告）日：2008-01-24

  The present invention is based, in part, on our discovery of compounds that inhibit an activity of a sirtuin (e.g., compounds that inhibit or preferentially inhibit an activity of SIRT2) and are therefore believed useful in the treatment or prevention of diseases associated with sirtuin activity. These diseases include, but are not limited to, neurological disorders such as Parkinson's Disease (PD).
• US8153803B2
  申请人：——

  公开号：US8153803B2

  公开（公告）日：2012-04-10
• [EN] COMPOSITIONS AND METHODS FOR MODULATING SIRTUIN ACTIVITY<br/>[FR] COMPOSITIONS ET PROCÉDÉS DESTINÉS À MODULER L'ACTIVITÉ DE LA SIRTUINE
  申请人：GEN HOSPITAL CORP

  公开号：WO2008011476A2

  公开（公告）日：2008-01-24

  [EN] The present invention is based, in part, on our discovery of compounds that inhibit an activity of a sirtuin (e.g., compounds that inhibit or preferentially inhibit an activity of SIRT2) and are therefore believed useful in the treatment or prevention of diseases associated with sirtuin activity. These diseases include, but are not limited to, neurological disorders such as Parkinson's Disease (PD).
  [FR] La présente invention concerne, en partie, la découverte de composés qui inhibent l'activité d'une sirtuine (par exemple, des composés qui inhibent ou qui inhibent de préférence une activité de SIRT2), et qui sont par conséquent considérés comme étant utiles dans le traitement ou la prévention de maladies associées à l'activité de la sirtuine. Ces maladies incluent, sans que ceci soit limitatif, les troubles neurologiques tels que la maladie de Parkinson (PD).