N-2-氯乙基-N-甲基氮丙啶鎓 | 57-54-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N-2-氯乙基-N-甲基氮丙啶鎓
• 英文名称: N-2-chloroethyl-N-methylaziridinium ion
• 英文别名: N-2-Chloroethyl-N-methylaziridinium；1-(2-chloroethyl)-1-methylaziridin-1-ium
• CAS: 57-54-5
• 化学式: C₅H₁₁ClN
• 分子量: 120.602
• InChiKey: LWMDBBLXXQCZLB-UHFFFAOYSA-N

物化性质

• 沸点：
  189.09°C (rough estimate)
• 密度：
  1.0166 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  恩比兴 在 sodium carbonate 作用下， 以 重水 为溶剂， 反应 2.0h， 生成 N-2-氯乙基-N-甲基氮丙啶鎓 、 NN'-2-chloroethyl-NN'-methylpiperazinium dichloride 、 NN'-2-chloroethyl-NN'-methylpiperazinium dichloride
  参考文献：
  名称：

  Golding, Bernard T.; Kebbell, Michael J.; Lockhart, Ian M., Journal of the Chemical Society. Perkin transactions II, 1987, p. 705 - 714

  摘要：

  DOI：

文献信息

• Stabilized Compositions of Volatile Alkylating Agents and Methods of Using Thereof
  申请人：Alonso Robert

  公开号：US20080194699A1

  公开（公告）日：2008-08-14

  A composition and method for treatment of cancer. The composition for treating a skin disorder, comprising: a Nitrogen Mustard or an HX salt of the Nitrogen Mustard, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier that does not include petrolatum or ethanol does not include petrolatum or ethanol. The method comprises topically applying the composition of a Nitrogen Mustard or a HX salt of the Nitrogen Mustard to the affected skin, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier does not include petrolatum or ethanol.
• Salts of Isophosphoramide Mustard and Analogs Thereof as Anti-Tumor Agents
  申请人：Morgan Lee Roy

  公开号：US20080267945A1

  公开（公告）日：2008-10-30

  The present disclosure relates to salts and compositions of isophosphoramide mustard and isophosphoramide mustard analogs. In one embodiment the salts can be represented by the formula wherein A + represents an ammonium species selected from the protonated (conjugate acid) or quaternary forms of aliphatic amines and aromatic amines, including basic amino acids, heterocyclic amines, substituted and unsubstituted pyridines, guanidines and amidines; and X and Y independently represent leaving groups. Also disclosed herein are methods for making such compounds and formulating pharmaceutical compositions thereof. Methods for administering the disclosed compounds to subjects, particularly to treat hyperproliferative disorders, also are disclosed.
• STABILIZED COMPOSITIONS OF ALKYLATING AGENTS AND METHODS OF USING SAME
  申请人：Alonso Robert

  公开号：US20090247645A1

  公开（公告）日：2009-10-01

  A composition and method for treatment of cancer. The composition for treating a skin disorder, comprising: an alkylating agent such as, for example, a Nitrogen Mustard or an HX salt of the Nitrogen Mustard, wherein the alkylating agent is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier that does not include petrolatum or ethanol does not include petrolatum or ethanol. The method comprises topically applying the composition of the alkylating agent to the affected skin, wherein the alkylating agent is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier does not include petrolatum or ethanol.
• STABILIZED COMPOSITIONS OF VOLATILE ALKYLATING AGENTS AND METHODS OF USING THEREOF
  申请人：Alonso Robert

  公开号：US20100041767A1

  公开（公告）日：2010-02-18

  A composition and method for treatment of cancer. The composition for treating a skin disorder, comprising: a Nitrogen Mustard or an HX salt of the Nitrogen Mustard, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier that does not include petrolatum or ethanol does not include petrolatum or ethanol. The method comprises topically applying the composition of a Nitrogen Mustard or a HX salt of the Nitrogen Mustard to the affected skin, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier does not include petrolatum or ethanol.
• METHODS FOR TREATING SKIN DISORDERS WITH TOPICAL NITROGEN MUSTARD COMPOSITIONS
  申请人：ALONSO Robert

  公开号：US20120157545A1

  公开（公告）日：2012-06-21

  Provided are methods for treating skin disorders comprising topically applying to the affected skin a composition comprising a nitrogen mustard or a pharmaceutically acceptable salt thereof.