3-[(4-Ethylphenyl)carbamoyl]propanoic acid | 200134-68-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-[(4-Ethylphenyl)carbamoyl]propanoic acid
• 英文别名: 4-(4-ethylanilino)-4-oxobutanoic acid
• CAS: 200134-68-5
• 化学式: C₁₂H₁₅NO₃
• mdl: MFCD00029840
• 分子量: 221.256
• InChiKey: AYICUSWSFLMREX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-[(4-Ethylphenyl)carbamoyl]propanoic acid 在 silica-supported benzoyl chloride 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以88%的产率得到1-(4-Ethylphenyl)pyrrolidine-2,5-dione
  参考文献：
  名称：

  Solid-Phase Synthesis ofN-Aryl Succinimides

  摘要：

  A new method upon adopting a solid-phase strategy for synthesis of N-aryl succinimides is described here, using the silica-bound benzoyl chloride (SBBC) as dehydrating agent in reaction with N-arylsuccinamic acids. The main advantage of this method is the recyclability of SBBC.

  DOI：

  10.1080/00397910802638529
• 作为产物：
  描述：

  丁二酸酐 、 4-乙基苯胺 以 乙醇 为溶剂， 生成 3-[(4-Ethylphenyl)carbamoyl]propanoic acid
  参考文献：
  名称：

  Solid-Phase Synthesis ofN-Aryl Succinimides

  摘要：

  A new method upon adopting a solid-phase strategy for synthesis of N-aryl succinimides is described here, using the silica-bound benzoyl chloride (SBBC) as dehydrating agent in reaction with N-arylsuccinamic acids. The main advantage of this method is the recyclability of SBBC.

  DOI：

  10.1080/00397910802638529

文献信息

• [EN] DIAZEPANES DERIVATIVES USEFUL AS LFA INHIBITORS<br/>[FR] DIAZEPANES PHARMACEUTIQUEMENT ACTIFS
  申请人：NOVARTIS AG

  公开号：WO2004065382A1

  公开（公告）日：2004-08-05

  Pharmaceutically active diazepanes, e.g. useful for treating disorders or diseases mediated by LFA-1/ICAM-1, LFA-1/ICAM-2, LFA-1/ICAM-3 or LFA-1/JAM-1 interactions.

  具有药用活性的二氮杂环庚烷类化合物，例如用于治疗由LFA-1/ICAM-1、LFA-1/ICAM-2、LFA-1/ICAM-3或LFA-1/JAM-1相互作用介导的疾病或疾病。
• NOVEL TRICARBOCYANINE-CYCLODEXTRIN(S) CONJUGATES AND USE THEREOF
  申请人：CYANAGEN S.R.L.

  公开号：US20150328342A1

  公开（公告）日：2015-11-19

  The present invention relates to novel tricarbocyanine-cyclodextrin(s) conjugates useful as markers in the diagnosis of kidney diseases, a diagnostic composition comprising said conjugates, their use and their production.

  本发明涉及新型三芳基氰化物-环糊精共轭物，可用作肾脏疾病诊断中的标记物，包括所述共轭物的诊断组合物，它们的使用和生产。
• COMPOUNDS FOR POSITRON EMISSION TOMOGRAPHY
  申请人：Endocyte, Inc.

  公开号：EP3533473A2

  公开（公告）日：2019-09-04

  Described herein are compounds, compositions, and methods for diagnosing and/or monitoring pathogenic disease using positron emission tomography. Also described are conjugates of the formula B-L-P, wherein B is a radical of a targeting agent selected from vitamin receptor binding ligands (such as folate), PSMA binding ligands, or PSMA inhibitors; L is a divalent linker comprising aspartic acid, lysine, or arginine, and P is a radical of an imaging agent or radiotherapy agent, such as a radionuclide or radionuclide containing group, or a radical of a compound capable of binding a radionuclide, such as a metal chelating group.

  本文描述了利用正电子发射断层扫描诊断和/或监测致病性疾病的化合物、组合物和方法。还描述了式 B-L-P 的共轭物，其中 B 是选自维生素受体结合配体（如叶酸）、PSMA 结合配体或 PSMA 抑制剂的靶向药的基团；L 是由天冬氨酸、赖氨酸或精氨酸组成的二价连接体，P 是成像剂或放疗剂的基团，如放射性核素或含放射性核素的基团，或能结合放射性核素的化合物的基团，如金属螯合基团。
• SALTS OF PAROXETINE
  申请人：SMITHKLINE BEECHAM PLC

  公开号：EP1091958A1

  公开（公告）日：2001-04-18
• Compounds for Positron Emission Tomography
  申请人：ENDOCYTE, INC.

  公开号：US20160287731A1

  公开（公告）日：2016-10-06

  Described herein are compounds, compositions, and methods for diagnosing and/or monitoring pathogenic disease using positron emission tomography. Also described are conjugates of the formula B-L-P, wherein B is a radical of a targeting agent selected from vitamin receptor binding ligands (such as folate), PSMA binding ligands, or PSMA inhibitors; L is a divalent linker comprising aspartic acid, lysine, or arginine, and P is a radical of an imaging agent or radiotherapy agent, such as a radionuclide or radionuclide containing group, or a radical of a compound capable of binding a radionuclide, such as a metal chelating group.