3-cyclopropyl-1-[(4-methylphenyl)sulfonyl]-1H-pyrazole

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-cyclopropyl-1-[(4-methylphenyl)sulfonyl]-1H-pyrazole
• 英文别名: 3-cyclopropyl-1-(4-methylphenyl)sulfonylpyrazole
• 化学式: C₁₃H₁₄N₂O₂S
• 分子量: 262.33
• InChiKey: PVDUBNAZNGJYFQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  60.3
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• QUINOXALINE DERIVATIVES AS PI3 KINASE INHIBITORS
  申请人：GlaxoSmithKline LLC

  公开号：EP2173354A1

  公开（公告）日：2010-04-14
• [EN] QUINOXALINE DERIVATIVES AS PI3 KINASE INHIBITORS<br/>[FR] DÉRIVÉS DES QUINOXALINES UTILISÉS COMME INHIBITEURS DES PI3-KINASES
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2009021083A1

  公开（公告）日：2009-02-12

  Invented is a method of inhibiting the activity/function of PI3 kinases using quinoxaline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoxaline derivatives.