1,2-bis[(2,5-dimethoxyphenyl)(phenyl)phosphino]ethane | 1064156-46-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,2-bis[(2,5-dimethoxyphenyl)(phenyl)phosphino]ethane
• 英文别名: (2,5-Dimethoxyphenyl)-[2-[(2,5-dimethoxyphenyl)-phenylphosphanyl]ethyl]-phenylphosphane
• CAS: 1064156-46-2
• 化学式: C₃₀H₃₂O₄P₂
• 分子量: 518.529
• InChiKey: RTUPSASRVQOJJL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  36
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] METHOD FOR INCREASING THE ENANTIOMERIC EXCESS OF CHIRAL PHOSPHINE OXIDES, SULPHIDES, IMIDES AND BORANES<br/>[FR] PROCÉDÉ POUR AUGMENTER L'EXCÈS ÉNANTIOMÉRIQUE DES OXYDES, DES SULFURES, ET DES IMIDES DE PHOSPHINE AINSI QUE DES PHOSPHINE-BORANES CHIRAUX
  申请人：CELTIC CATALYSTS LTD

  公开号：WO2010004278A1

  公开（公告）日：2010-01-14

  The present invention relates to a method for increasing the enantiomeric excess of a chiral phosphine oxide, a chiral phosphine sulphide, a chiral phosphine-borane and a chiral phosphine imide said method comprising the steps of: (a) contacting said chiral phosphine oxide, sulphide, imide or borane with a solvent to form a slurry; (b) partitioning the phosphine oxide, sulphide, imide or borane either into the solvent or as an insoluble product; and (c) optionally, isolating the partitioned phosphine oxide, sulphide, imide or borane.

  本发明涉及一种用于增加手性亚磷酰氧化物、手性亚磷酰硫、手性亚磷酰-硼烷和手性亚磷酰亚胺的对映体过量值的方法，所述方法包括以下步骤：(a)将所述手性亚磷酰氧化物、硫、亚胺或硼烷与溶剂接触以形成悬浮液；(b)将亚磷酰氧化物、硫、亚胺或硼烷分配到溶剂中或作为不溶产物；以及(c)可选地，分离出分配的亚磷酰氧化物、硫、亚胺或硼烷。
• CHIRAL PHOSPHOROUS COMPOUNDS
  申请人：Gilheany Declan

  公开号：US20100168456A1

  公开（公告）日：2010-07-01

  The present invention provides P-chiral compounds of general formulae (II) and (III): in formula (II) at least one of R 21 , R 25 , R 26 and R 30 is independently selected from CM alkyl, CF 3 , C 1-4 alkoxy, phenyl and benzyloxy and the remaining substituents selected from R 21 , R 25 , R 26 and R 30 are hydrogen; at least one of R 22, R 24, R 27 and R 29 are independently selected from C 1-14 alkyl, CF 3, C 1-14 alkoxy, phenyl and benzyloxy and the remaining substituents selected, from R 22 , R 24, R 27 and R 29 are hydrogen; and R 23 and R28 are independently selected from hydrogen, CM alkyl, CF 3 , C 1-14 alkoxy, phenyl and benzyloxy; in formula (III) at least one of R 21 , R 25 , R 26 and R 30 is independently selected from phenyl and benzyloxy and the remaining substituents selected from R 21 , R 25 , R— 26 and R 30 are hydrogen; and R 22 , R— 23 R 24, R 27 , R 28 and R 29 are independently selected from hydrogen, C 1-14 alkyl, CF 3 , C 1-14 alkoxy, phenyl and benzyloxy.

  本发明提供了一般式（II）和（III）的P-手性化合物：在式（II）中，R21、R25、R26和R30中至少有一个是独立选择的CM烷基，CF3，C1-4烷氧基，苯基和苄氧基，其余取代基选择自R21、R25、R26和R30为氢；R22、R24、R27和R29中至少有一个是独立选择的C1-14烷基，CF3，C1-14烷氧基，苯基和苄氧基，其余取代基选择自R22、R24、R27和R29为氢；R23和R28独立选择自氢，CM烷基，CF3，C1-14烷氧基，苯基和苄氧基；在式（III）中，R21、R25、R26和R30中至少有一个是独立选择的苯基和苄氧基，其余取代基选择自R21、R25、R-26和R30为氢；R22、R-23、R24、R27、R28和R29独立选择自氢，C1-14烷基，CF3，C1-14烷氧基，苯基和苄氧基。
• CHIRAL DIPHOSPINES, METHODS FOR THEIR PREPARATION, TRANSITION METAL COMPLEXES COMPRISING THEM AND USE IN CHIRAL SYNTHESIS
  申请人：Celtic Catalysts Limited

  公开号：EP2139905A2

  公开（公告）日：2010-01-06
• US8067642B2
  申请人：——

  公开号：US8067642B2

  公开（公告）日：2011-11-29
• [EN] CHIRAL PHOSPHORUS COMPOUNDS<br/>[FR] COMPOSÉS CHIRAUX DU PHOSPHORE
  申请人：CELTIC CATALYSTS LTD

  公开号：WO2008117054A2

  公开（公告）日：2008-10-02

  [EN] The present invention provides P-chiral compounds of general formula (II) and (III): wherein at least one of R₂₁, R₂₅, R₂₆ and R₃₀ is independently selected from C_1-4 alkyl, CF₃, C_1-4 alkoxy, phenyl and benzyloxy and the remaining substituents selected from R₂₁, R₂₅, R₂₆ and R₃₀ are hydrogen; at least one of R₂₂, R₂₄, R₂₇ and R₂₉ are independently selected from C_1-4 alkyl, CF₃, C_1-4 alkoxy, phenyl and benzyloxy and the remaining substituents selected from R₂₂, R₂₄, R₂₇ and R₂₉ are hydrogen; and R₂₃ and R₂₈ are independently selected from hydrogen, C_1-4 alkyl, CF3, C_1-4 alkoxy, phenyl and benzyloxy; Formula (III): wherein at least one of R₂₁, R₂₅, R₂₆ and R₃₀ is independently selected from phenyl and benzyloxy and the remaining substituents selected from R₂₁, R₂₅, R₂₆ and R₃₀ are hydrogen; and R₂₂, R₂₃, R₂₄, R₂₇, R₂₈ and R₂₉ are independently selected from hydrogen, C_1-4 alkyl, CF₃, C_1-4 alkoxy, phenyl and benzyloxy.wherein at least one of R₂₁, R₂₅, R₂₆ and R₃₀ is independently selected from phenyl and benzyloxy and the remaining substituents selected from R₂₁, R₂₅, R₂₆ and R₃₀ are hydrogen; and R₂₂, R₂₃, R₂₄, R₂₇, R₂₈ and R₂₉ are independently selected from hydrogen, C_1-4 alkyl, CF₃, C_1-4 alkoxy, phenyl and benzyloxy.
  [FR] La présente invention concerne des composés chiraux P de formule générale (II) et (III) : dans lesquelles au moins un de R₂₁, R₂₅, R₂₆ et R₃₀ est indépendamment choisi parmi les groupes alkyle en C_1-4, CF₃, alcoxy en C_1-4, phényle et benzyloxy et les autres substituants choisis parmi R₂₁, R₂₅, R₂₆ et R₃₀ sont un atome d'hydrogène ; au moins un de R₂₂, R₂₄, R₂₇ et R₂₉ est indépendamment choisi parmi les groupes alkyle en C_1-4, CF₃, alcoxy en C_1-4, phényle et benzyloxy et les autres substituants choisis parmi R₂₂, R₂₄, R₂₇ et R₂₉ sont un atome d'hydrogène ; et R₂₃ et R₂₈ sont indépendamment choisis parmi un atome d'hydrogène, un groupe alkyle en C_1-4, CF₃, alcoxy en C_1-4, phényle et benzyloxy ; Formule (III) : dans laquelle au moins un de R₂₁, R₂₅, R₂₆ et R₃₀ est indépendamment choisi parmi les groupes phényle et benzyloxy et les autres substituants choisis parmi R₂₁, R₂₅, R₂₆ et R₃₀ sont un atome d'hydrogène ; et R₂₂, R₂₃, R₂₄, R₂₇, R₂₈ et R₂₉ sont indépendamment choisis parmi un atome d'hydrogène, un groupe alkyle en C_1-4, CF₃, alcoxy en C_1-4, phényle et benzyloxy, dans laquelle au moins un de R₂₁, R₂₅, R₂₆ et R₃₀ est indépendamment choisi parmi les groupes phényle et benzyloxy et les autres substituants choisis parmi R₂₁, R₂₅, R₂₆ et R₃₀ sont un atome d'hydrogène ; et R₂₂, R₂₃, R₂₄, R₂₇, R₂₈ et R₂₉ sont indépendamment choisis parmi un atome d'hydrogène, un groupe alkyle en C_1-4, CF₃, alcoxy en C_1-4, phényle et benzyloxy.