2-amino-6-(3,4-dichloro-phenyl)-5,6-dihydro-3H-pyrimidin-4-one | 99184-26-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-amino-6-(3,4-dichloro-phenyl)-5,6-dihydro-3H-pyrimidin-4-one
• 英文别名: 2-Amino-6-(3,4-dichlor-phenyl)-5,6-dihydro-3H-pyrimidin-4-on；2-amino-6-(3,4-dichloro-phenyl)-5,6-dihydro-3H-pyrimidin-4-one；2-amino-4-(3,4-dichlorophenyl)-4,5-dihydro-1H-pyrimidin-6-one
• CAS: 99184-26-6
• 化学式: C₁₀H₉Cl₂N₃O
• 分子量: 258.107
• InChiKey: UZBGOMQLPVPSHH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  67.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-(3,4-二氯苯基)-2-丙烯酰氯 在 N,N-二异丙基乙胺 作用下， 以 氯仿 为溶剂， 生成 2-amino-6-(3,4-dichloro-phenyl)-5,6-dihydro-3H-pyrimidin-4-one
  参考文献：
  名称：

  Synthesis of Quinazolin‐2,4,6‐triamine Derivatives as Non‐purine Xanthine Oxidase Inhibitors and Exploration of Their Toxicological Potential**

  摘要：

  摘要 在这项工作中，合成了一组新的喹唑啉-2,4,6-三胺衍生物，以探索其作为黄嘌呤氧化酶（XO）抑制剂、超氧化物清除剂的潜在生物活性，并筛选其毒理学特征。在所有合成的化合物中，B1 对牛黄嘌呤氧化酶（bXO）的抑制活性优于别嘌醇（IC50=1.56 μM 和 IC50=6.99 μM）。作为超氧化物清除剂，B1、B2 和 B13 的效果优于别嘌醇（分别为 97.3%、82.1%、87.4% 和 69.4%）。在毒性方面，B1 对 HCT-15 癌细胞的细胞毒性低于甲氨蝶呤。雌性和雄性小鼠细胞的凋亡结果表明，就诱导凋亡的平均频率而言，B1 和 B2 与 CrO3（阳性对照组）表现相似；而 B13 诱导凋亡的效果与 DMSO 和对照组相似。最后，与 CrO3 相比，B1、B2 和 B13 在小鼠微核模型中没有诱发遗传毒性。

  DOI：

  10.1002/cmdc.202300184

文献信息

• [EN] SUBSTITUTED AMINO-COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSES AMINO SUBSTITUES ET UTILISATION DE CES COMPOSE
  申请人：ASTRAZENECA AB

  公开号：WO2006041404A1

  公开（公告）日：2006-04-20

  This invention relates to novel compounds having the structural formula Ia or formula Ib: Ia Ib and their pharmaceutically acceptable salts, tautomers or in vivo hydrolysable precursors, compositions and methods of use thereof. These novel compounds provide a treatment or prophylaxis of Aβ related pathologies such as cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.

  这项发明涉及具有结构式Ia或结构式Ib的新化合物：Ia Ib及其药用可接受的盐、互变异构体或体内可水解的前体，以及其组合物和使用方法。这些新化合物提供了治疗或预防与Aβ相关的病理学，如认知障碍、阿尔茨海默病、神经退行性疾病和痴呆症的方法。
• Substituted Amino-Compounds and Uses Thereof
  申请人：Albert Jeffrey Scott

  公开号：US20090221579A1

  公开（公告）日：2009-09-03

  This invention relates to novel compounds having the structural formula Ia or formula Ib: Ia Ib and their pharmaceutically acceptable salts, tautomers or in vivo hydrolysable precursors, compositions and methods of use thereof. These novel compounds provide a treatment or prophylaxis of Aβ related pathologies such as cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.

  本发明涉及具有结构式Ia或式Ib的新化合物：Ia Ib及其药学上可接受的盐、互变异构体或体内水解前体，以及其使用的组合物和方法。这些新化合物提供了治疗或预防与Aβ相关的病理学，如认知障碍、阿尔茨海默病、神经退行性和痴呆症的方法。
• Substituted Amino-Pyrimidones and Uses Thereof
  申请人：Albert Jeffrey Scott

  公开号：US20090062282A1

  公开（公告）日：2009-03-05

  This invention relates to novel compounds having the structural formula Ia or formula Ib below: (Ia, Ib), and their pharmaceutically acceptable salts, tautomers or in vivo hydrolysable precursors, compositions and methods of use thereof. These novel compounds provide a treatment or prophylaxis of Aβ related pathologies such as cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.

  本发明涉及具有下列结构式Ia或结构式Ib的新化合物：（Ia，Ib），以及它们的药学上可接受的盐，互变异构体或体内水解前体，以及它们的组合物和使用方法。这些新化合物可用于治疗或预防与Aβ相关的病理学，如认知障碍，阿尔茨海默病，神经退行性和痴呆症。
• Application of Fragment-Based Lead Generation to the Discovery of Novel, Cyclic Amidine β-Secretase Inhibitors with Nanomolar Potency, Cellular Activity, and High Ligand Efficiency
  作者：Philip D. Edwards、Jeffrey S. Albert、Mark Sylvester、David Aharony、Donald Andisik、Owen Callaghan、James B. Campbell、Robin A. Carr、Gianni Chessari、Miles Congreve、Martyn Frederickson、Rutger H. A. Folmer、Stefan Geschwindner、Gerard Koether、Karin Kolmodin、Jennifer Krumrine、Russell C. Mauger、Christopher W. Murray、Lise-Lotte Olsson、Sahil Patel、Nate Spear、Gaochao Tian

  DOI：10.1021/jm070829p

  日期：2007.11.1

  Fragment-based lead generation has led to the discovery of a novel series of cyclic amidine-based inhibitors of beta-secretase (BACE-1). Initial fragment hits with an isocytosine core having millimolar potency were identified via NMR affinity screening. Structure-guided evolution of these fragments using X-ray crystallography together with potency determination using surface plasmon resonance and functional enzyme inhibition assays afforded micromolar inhibitors. Similarity searching around the isocytosine core led to the identification of a related series of inhibitors, the dihydroisocytosines. By leveraging the knowledge of the ligand-BACE-1 recognition features generated from the isocytosines, the dihydroisocytosines were efficiently optimized to submicromolar potency. Compound 29, with an IC50 of 80 nM, a ligand efficiency of 0.37, and cellular activity of 470 nM, emerged as the lead structure for future optimization.
• 2-amino-6-aryl-5, 6-dihydro-4-hydroxy-pyrimidines
  申请人：SEARLE &

  公开号：US02748120A1

  公开（公告）日：1956-05-29