6-(Diethylamino)pyridine-2-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-(Diethylamino)pyridine-2-carboxylic acid
• 化学式: C₁₀H₁₄N₂O₂
• mdl: MFCD03970790
• 分子量: 194.23
• InChiKey: KKMJSCAACAPSKW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  53.4
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• INHIBITORS OF PRENYL-PROTEIN TRANSFERASES
  申请人：Merck & Co., Inc.

  公开号：EP1165084A1

  公开（公告）日：2002-01-02
• EP1165084A4
  申请人：——

  公开号：EP1165084A4

  公开（公告）日：2002-05-15
• [EN] INHIBITORS OF PRENYL-PROTEIN TRANSFERASES<br/>[FR] INHIBITEURS DE PRENYL-PROTEINE TRANSFERASES
  申请人：MERCK & CO INC

  公开号：WO2000051614A1

  公开（公告）日：2000-09-08

  The present invention comprises piperazine-containing compounds which inhibit prenyl-protein transferases. In particular, the invention relates to prenyl-protein transferase inhibitors which are efficacious in vivo as inhibitors of geranylgeranyl-protein transferase type I (GGTase-I) and that inhibit the cellular processing of both the H-Ras protein and the K4B-Ras protein. Such therapeutic compounds are useful in the treatment of cancer.
• [EN] METHOD OF PREVENTING OSTEOPOROSIS<br/>[FR] PROCEDE DE PREVENTION DE L'OSTEOPOROSE
  申请人：MERCK & CO INC

  公开号：WO2001022963A1

  公开（公告）日：2001-04-05

  The present invention relates to a method of preventing or inhibiting bone resorption in a mammal comprising administering to a mammal in need thereof a therapeutically effective amount of an inhibitor of geranylgeranyl-protein transferase type I.