N-[(9,10-二氢-4-羟基-9,10-二氧代蒽)-1-基]-beta-丙氨酸甲酯 | 71720-87-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 中文名称: N-[(9,10-二氢-4-羟基-9,10-二氧代蒽)-1-基]-beta-丙氨酸甲酯
• 英文名称: beta-Alanine, N-(9,10-dihydro-4-hydroxy-9,10-dioxo-1-anthracenyl)-, methyl ester
• 英文别名: methyl 3-[(4-hydroxy-9,10-dioxoanthracen-1-yl)amino]propanoate
• CAS: 71720-87-1
• 化学式: C₁₈H₁₅NO₅
• 分子量: 325.3
• InChiKey: YPAXZARCKVMKEA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  92.7
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Transcription factor modulating compounds and methods of use thereof
  申请人：Levy Stuart B.

  公开号：US20090131401A1

  公开（公告）日：2009-05-21

  Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.

  本发明提供了可用作抗感染剂的取代苯并咪唑化合物，其可降低微生物的耐药性、毒力或生长。本发明还提供了制备和使用取代苯并咪唑化合物的方法，以及其制备的药物制剂，例如用于减少抗生素耐药性和抑制生物膜的制剂。
• COMPOUNDS FOR TREATING CORONAVIRUS INFECTION
  申请人：NLC Pharma Ltd

  公开号：US20220387354A1

  公开（公告）日：2022-12-08

  Described herein are compounds of Formula I: wherein R 1 -R 6 are as described herein, for use in the treatment of a coronavirus infection; a method of inhibiting a coronavirus 3CL protease, by contacting the 3CL protease with a compound of Formula I; as well as methods pharmaceutical composition comprising a compound of Formula I and at least one phospholipid, wherein a weight ratio of the phospholipid(s) to the compound in the composition is in a range of from 10:1 to 1:10. Further described herein is a method of treating a coronavirus infection in a subject in need thereof, by administering to the subject at least one compound that exhibits at least two of: inhibition of an activity of a 3CL protease of the coronavirus; inhibition of inflammation in the subject; and inhibition of autophagy in the subject.
• US3945991A
  申请人：——

  公开号：US3945991A

  公开（公告）日：1976-03-23
• US8436031B2
  申请人：——

  公开号：US8436031B2

  公开（公告）日：2013-05-07