2-(6'-aminopyridin-3-yl)-6-methylbenzothiazole | 1448780-06-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 2-(6'-aminopyridin-3-yl)-6-methylbenzothiazole
• 英文别名: 5-(6-Methyl-1,3-benzothiazol-2-yl)pyridin-2-amine；5-(6-methyl-1,3-benzothiazol-2-yl)pyridin-2-amine
• CAS: 1448780-06-0
• 化学式: C₁₃H₁₁N₃S
• mdl: MFCD22244833
• 分子量: 241.316
• InChiKey: CBBAVPAFROIHAD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.076
• 拓扑面积：
  80
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氨基吡啶-5-硼酸,频哪醇酯 、 2-溴-6-甲基苯并噻唑 在 potassium carbonate 、 1,1'-双(二苯膦基)二茂铁二氯化钯(II)二氯甲烷复合物 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 13.0h， 生成 2-(6'-aminopyridin-3-yl)-6-methylbenzothiazole
  参考文献：
  名称：

  Straightforward synthesis of PET tracer precursors used for the early diagnosis of Alzheimers disease through Suzuki–Miyaura cross-coupling reactions

  摘要：

  In positron emission tomography [C-11[PIB, Pittsburgh Compound-B, is currently the most widely used radiopharmaceutical for the early diagnosis of Alzheimer's disease. Synthetic routes for the preparation of the precursor of [C-11]PIB are reported in the literature. These strategies require multiple steps and the use of protecting groups. This paper describes a simple one-step synthesis of the precursor of [C-11]PIB through a Suzuki-Miyaura coupling reaction using thermal conditions or microwave activation. These methods were successfully applied to the synthesis of various 2-arylbenzothiazole and 2-pyridinylbenzothiazole compounds including [F-18] precursor derivatives of PIB containing a nitro function. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.06.085

文献信息

• Straightforward synthesis of PET tracer precursors used for the early diagnosis of Alzheimers disease through Suzuki–Miyaura cross-coupling reactions
  作者：Guillaume Bort、Maité Sylla-Iyarreta Veitía、Clotilde Ferroud

  DOI：10.1016/j.tet.2013.06.085

  日期：2013.9

  In positron emission tomography [C-11[PIB, Pittsburgh Compound-B, is currently the most widely used radiopharmaceutical for the early diagnosis of Alzheimer's disease. Synthetic routes for the preparation of the precursor of [C-11]PIB are reported in the literature. These strategies require multiple steps and the use of protecting groups. This paper describes a simple one-step synthesis of the precursor of [C-11]PIB through a Suzuki-Miyaura coupling reaction using thermal conditions or microwave activation. These methods were successfully applied to the synthesis of various 2-arylbenzothiazole and 2-pyridinylbenzothiazole compounds including [F-18] precursor derivatives of PIB containing a nitro function. (C) 2013 Elsevier Ltd. All rights reserved.