N-[2,4-二甲基-5-(三氟甲基磺酰基氨基)苯基]乙酰胺2-(2-羟基乙基氨基)乙醇盐 | 53780-36-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-[2,4-二甲基-5-(三氟甲基磺酰基氨基)苯基]乙酰胺2-(2-羟基乙基氨基)乙醇盐
• 英文名称: Mefluidide-diolamine
• 英文别名: N-[2,4-dimethyl-5-(trifluoromethylsulfonylamino)phenyl]acetamide;2-(2-hydroxyethylamino)ethanol
• CAS: 53780-36-2
• 化学式: C15H24F3N3O5S
• 分子量: 415.4
• InChiKey: JDMXBYDZNLFFCJ-UHFFFAOYSA-N

物化性质

• 熔点：
  106-108 °C
• 溶解度：
  In water, 556 mg/g at 25 °C
• 密度：
  0.69 g/cu cm at 25 °C
• 蒸汽压力：
  <1.0X10-7 mm Hg at 25 °C

计算性质

• 辛醇/水分配系数(LogP)：
  1.08
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  136
• 氢给体数：
  5
• 氢受体数：
  10

ADMET

毒理性

• 毒性总结

识别和使用：敌草隆-二醇胺是一种植物生长调节剂和杀虫剂。人体研究：无数据可用。动物研究：在兔子上进行的21天内，每天剂量为1000毫克/千克的敌草隆-二醇胺皮肤测试未表现出毒性。在1000毫克/千克/天的剂量下，效果仅限于应用部位轻微红斑。在大鼠上进行的测试中，没有出现与治疗相关的畸形或发育变异。在几项研究中观察到神经毒性的临床迹象（如颤动、共济失调、肌无力、肢体张力下降、流涎）：在兔子的14天口服研究中剂量为或超过200毫克/千克/天，在鸡的脱髓鞘研究中为1000毫克/千克/天，在大鼠的两个发育毒性研究中为115毫克/千克/天。在兔子的皮肤毒性研究中，观察到坐骨神经水肿和肿胀伴髓鞘丧失的剂量为720毫克/千克及以上。然而，在使用含有28.8%敌草隆-二醇胺的制剂进行的额外皮肤测试中，并未看到这些效果，测试持续时间相似。敌草隆-二醇胺在沙门氏菌typhimurium测试菌株TA98、TA100、TA1535、TA1537和TA1538的组氨酸位点上诱导反向突变的检测中，无论是否代谢激活均为阴性。生态毒性研究：敌草隆-二醇胺对虹鳟鱼（Oncorhynchus mykiss）、蓝鳃太阳鱼（Lepomis macrochirus）、羊头鱼（Cyprinodon variegatus）、水蚤（Daphnia magna）和河口海洋米斯德（Mysidopsis bahia）的毒性几乎可以忽略不计。它对河口海洋东部牡蛎（Crassostrea virginica）有轻微毒性。在急性接触基础上对蜜蜂几乎没有毒性。在植物上，毒性症状包括生长受阻、黄化、坏死和变形。

IDENTIFICATION AND USE: Mefluidide-diolamine is a plant growth regulator and pesticide. HUMAN STUDIES: There are no data available. ANIMAL STUDIES: Mefluidide-diolamine was not dermally toxic when tested in rabbits at doses of 1000 mg/kg/day for 21 days. Effects were limited to slight erythema at the application site at the 1000 mg/kg/day dose. There were no treatment-related malformations or developmental variations when tested in rats. Clinical signs of neurotoxicity (such as tremors, ataxia, atonia, decreased limb tone, salivation) were seen in several studies (14-day oral in rabbit at or above 200 mg/kg/day, demyelination study in chickens at 1000 mg/kg/day and two developmental toxicity studies in rats at 115 mg/kg/day. Edema and swelling with myelin loss in sciatic nerve was observed in a dermal toxicity study in rabbits at doses of 720 mg/kg and above. However, these effects were not seen in an additional dermal test of similar duration using a 28.8% formulation of mefluidide-diolamine. Mefluidide-diolamine was assayed for induction of reverse mutations at the histidine locus of Salmonella typhimurium tester strains TA98, TA100, TA1535, TA1537 and TA1538 and it was negative with or without metabolic activation. ECOTOXICITY STUDIES: Mefluidide-diolamine was practically non-toxic to rainbow trout (Oncorhynchus mykiss), bluegill sunfish (Lepomis macrochirus), sheepshead minnow (Cyprinodon variegatus, waterflea (Daphnia magna, and to the estuarine marine mysid (Mysidopsis bahia). It was slightly toxic to the estuarine marine eastern oyster (Crassostrea virginica). It was practically nontoxic to honeybees on an acute contact basis. In plants symptoms of toxicity included stunting, chlorosis, necrosis and distortion.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 副作用

神经毒素 - 其他中枢神经系统神经毒素

Neurotoxin - Other CNS neurotoxin

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 解毒与急救

/SRP:/ 立即急救：确保已经进行了充分的中毒物清除。如果患者停止呼吸，开始人工呼吸，最好使用需求阀复苏器、袋阀面罩装置或口袋面罩，按训练操作。如有必要，执行心肺复苏。立即用缓慢流动的水冲洗受污染的眼睛。不要催吐。如果发生呕吐，让患者前倾或置于左侧卧位（如果可能的话，头部向下）以保持呼吸道畅通，防止吸入性肺炎。保持患者安静，维持正常体温。寻求医疗救助。 /毒物A和B/

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

/SRP:/ 基本治疗：建立专利气道（如有需要，使用口咽或鼻咽气道）。如有必要，进行吸痰。观察呼吸不足的迹象，如有需要，辅助通气。通过非循环呼吸面罩以10至15升/分钟的速度给予氧气。监测肺水肿，如有必要，进行治疗……。监测休克，如有必要，进行治疗……。预防癫痫发作，如有必要，进行治疗……。对于眼睛污染，立即用水冲洗眼睛。在运输过程中，用0.9%的生理盐水（NS）持续冲洗每只眼睛……。不要使用催吐剂。对于摄入，如果患者能吞咽、有强烈的干呕反射且不流口水，则用温水冲洗口腔，并给予5毫升/千克，最多200毫升的水进行稀释……。在去污后，用干燥的无菌敷料覆盖皮肤烧伤……。/毒药A和B/

/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poisons A and B/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

/SRP:/ 高级治疗：对于昏迷、严重肺水肿或严重呼吸困难的病人，考虑进行口咽或鼻咽插管以控制气道。使用带气囊的面罩进行正压通气技术可能有益。考虑使用药物治疗肺水肿……。对于严重的支气管痉挛，考虑给予β受体激动剂，如沙丁胺醇……。监测心率和必要时治疗心律失常……。开始静脉输注5%葡萄糖溶液（D5W），以“保持开放”，最小流量/ SRP。如果出现低血容量的迹象，使用0.9%盐水（NS）或乳酸钠林格氏液（LR）。对于伴有低血容量迹象的低血压，谨慎给予液体。注意液体过载的迹象……。使用地西泮（安定）或劳拉西泮（阿蒂凡）治疗癫痫……。使用丙美卡因氢氯化物协助眼部冲洗……。/毒素A和B/

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W TKO /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) or lorazepam (Ativan) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poisons A and B/

来源:Hazardous Substances Data Bank (HSDB)

文献信息

• Methods and compositions for increasing the efficacy of biologically-active ingredients
  申请人：Windsor Brian J.

  公开号：US20060276339A1

  公开（公告）日：2006-12-07

  The invention provides methods and compositions for modulating the sensitivity of cells to cytotoxic compounds and other active agents. In accordance with the invention, compositions are provided comprising combinations of ectophosphatase inhibitors and active agents. Active agents include antibiotics, fungicides, herbicides, insecticides, chemotherapeutic agents, and plant growth regulators. By increasing the efficacy of active agents, the invention allows use of compositions with lowered concentrations of active ingredients.
• US4556410A
  申请人：——

  公开号：US4556410A

  公开（公告）日：1985-12-03