5,6-Dimethyl-s-triazolo<1,5-a>pyrimidin | 55605-56-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三唑并嘧啶类
• 英文名称: 5,6-Dimethyl-s-triazolo<1,5-a>pyrimidin
• 英文别名: 5,6-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine；5,6-Dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin；5,6-Dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine
• CAS: 55605-56-6
• 化学式: C₇H₈N₄
• 分子量: 148.167
• InChiKey: NRJXMWBGMWNVMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  43.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-Oxo-5,6-dimethyl-1,2,4-triazolo<2,3-a>-pyrimidin 在 三氯氧磷 作用下， 生成 5,6-Dimethyl-s-triazolo<1,5-a>pyrimidin
  参考文献：
  名称：

  The Structure of Certain Polyazaindenes. II. The Product from Ethyl Acetoacetate and 3-Amino-1,2,4-triazole

  摘要：

  DOI：

  10.1021/jo01088a014

文献信息

• NOVEL PHENYLIMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS
  申请人：Ritzén Andreas

  公开号：US20100016303A1

  公开（公告）日：2010-01-21

  This invention is directed to compounds, which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula I. The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention also provides a method of treating a subject suffering from a drug addiction comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I.

  这项发明涉及一类PDE10A酶抑制剂化合物。该发明提供了一种包含所述发明化合物的治疗有效量和药学可接受载体的药物组合物。本发明还提供了制备式I化合物的方法。本发明还提供了一种治疗患有神经退行性疾病的受试者的方法，包括向受试者投予式I化合物的治疗有效量。本发明还提供了一种治疗患有药物成瘾的受试者的方法，包括向受试者投予式I化合物的治疗有效量。本发明还提供了一种治疗患有精神障碍的受试者的方法，包括向受试者投予式I化合物的治疗有效量。
• [EN] HETEROCYCLIC INHIBITORS OF ENPP1<br/>[FR] INHIBITEURS HÉTÉROCYCLIQUES D'ENPP1
  申请人：VOLASTRA THERAPEUTICS INC

  公开号：WO2021257614A1

  公开（公告）日：2021-12-23

  The present disclosure relates generally to inhibitors of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), compositions thereof, and methods of using said compounds and compositions thereof. More specifically, the present disclosure relates to triazolopyrimidine and imidazolopyrimidine inhibitors of ENPP1 and methods of their use for treating disease mediated by ENPP1.

  本公开涉及抑制细胞外核苷酸焦磷酸酶/磷酸二酯酶1（ENPP1）的抑制剂，其组成物和使用该化合物和其组成物的方法。更具体地，本公开涉及三唑嘧啶和咪唑嘧啶抑制剂的ENPP1及其使用方法，用于治疗由ENPP1介导的疾病。
• 1,2,4-TRIAZOLO[1,5-a] PYRIMIDINE DERIVATIVE AS COPPER CORROSION INHIBITOR
  申请人：ECOLAB USA INC.

  公开号：US20200362467A1

  公开（公告）日：2020-11-19

  The present disclosure relates to corrosion inhibitor compositions, formulations, and compounds. The compositions, formulations, and compounds may be used is various methods to inhibit corrosion of metallic surfaces in aqueous environments. The corrosion inhibitor compositions may include one of the following compounds or any combination of any of the compounds of formula (I):

  本公开涉及防腐蚀剂组成物、配方和化合物。这些组成物、配方和化合物可以用于各种方法中，以抑制水性环境中金属表面的腐蚀。防腐蚀剂组成物可以包括以下任一化合物或任何公式（I）化合物的任意组合：
• Inhibitors Of AKT Activity
  申请人：Chen Qi

  公开号：US20120077810A1

  公开（公告）日：2012-03-29

  The instant invention provides for substituted fused pyrimidine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.

  本发明提供了一种取代的融合嘧啶化合物，可以抑制Akt活性。特别地，所披露的化合物选择性地抑制一种或两种Akt同工型。本发明还提供了包含这种抑制化合物的组合物以及通过向需要治疗癌症的患者施用该化合物来抑制Akt活性的方法。
• HETEROCYCLIC HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME
  申请人：Jachmann Markus

  公开号：US20100137362A1

  公开（公告）日：2010-06-03

  A hydrazide compound represented by the formula (I), an N-oxide thereof or suitable salt thereof: has excellent pesticidal activity.

  一种由式(I)表示的腙酰肼类化合物，其N-氧化物或适当的盐：具有优异的杀虫活性。