benzyl 3-methylcarbazate | 37519-03-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzyl 3-methylcarbazate
• 英文别名: N¹-Benzyloxycarbonyl-N²-methyl-hydrazin；1-Carbobenzoxy-2-methylhydrazin；3-Methylcarbazinsaeure-benzylester；2-Methylhydrazinecarboxylic acid phenylmethyl ester；1-methyl-2-benzyloxycarbonylhydrazine；benzyl 2-methylhydrazinecarboxylate；N'-Methyl(benzyloxy)carbohydrazide；benzyl N-(methylamino)carbamate
• CAS: 37519-03-2
• 化学式: C₉H₁₂N₂O₂
• 分子量: 180.206
• InChiKey: PRIYUSMWEKKHHT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  50.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  benzyl 3-methylcarbazate 生成 α-<1-(2-Benzyloxycarbonyl-1-methylhydrazino)>-phenylacetyl-cyclohexylamin
  参考文献：
  名称：

  Monguzzi; Libassi; Pinza, Farmaco, Edizione Scientifica, 1976, vol. 31, # 8, p. 549 - 560

  摘要：

  DOI：
• 作为产物：
  描述：

  2-benzyl 1-tert-butyl 1-methylhydrazine-1,2-dicarboxylate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 以85%的产率得到benzyl 3-methylcarbazate
  参考文献：
  名称：

  3-substituted indole antiproliferative angiogenesis inhibitors

  摘要：

  具有下式的3-取代吲哚羰肼对抑制血管生成和细胞增殖具有用处。还揭示了抑制血管生成和细胞增殖的组合物以及抑制哺乳动物中的血管生成和癌症的方法。

  公开号：

  US20020091148A1

文献信息

• [EN] PRODRUGS OF FENCAMFAMINE<br/>[FR] PROMÉDICAMENTS DE FENCAMFAMINE
  申请人：PRAXIS BIOSCIENCES LLC

  公开号：WO2017048720A1

  公开（公告）日：2017-03-23

  Disclosed herein are pharmaceutical compositions comprising fencamfamine or fencamfamine related prodrug derivatives for targeted therapeutic applications and methods of synthesizing the compositions.

  本文披露了包含芬卡麦非或芬卡麦非相关的前药衍生物的药物组合物，用于靶向治疗应用，并且披露了合成这些组合物的方法。
• MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO
  申请人：Dow AgroSciences LLC

  公开号：US20170208810A1

  公开（公告）日：2017-07-27

  This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, compositions containing such molecules, and processes of using such molecules and compositions against such pests. These molecules and compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).

  这份披露涉及具有对节肢动物门、软体动物门和线虫门害虫具有杀虫效用的分子领域，用于生产此类分子的过程，用于这类过程的中间体，含有这类分子的组合物，以及使用这些分子和组合物对抗这些害虫的过程。这些分子和组合物可以用作螨虫杀剂、杀虫剂、螨虫剂、软体动物杀虫剂和线虫杀虫剂。本文披露了具有以下式（“式一”）的分子。
• Regiospecific Syntheses of the Monomethylated 3-Phenyldihydro-1,2,4-triazin-6(1H)-ones
  作者：DJ Collins、TC Hughes、WM Johnson

  DOI：10.1071/ch9960463

  日期：——

  Unambiguous syntheses of four unreported monomethylated derivatives of 3-phenyldihydro-1,2,4-triazin-6(1H)-ones, namely, the 1-methyl (2), 2-methyl (3), 4-methyl (4) and the imidic O-methyl derivative (5), are described. Regioselectivity was achieved for the synthesis of (2) by addition of ethyl glycinate to the 1,3-dipolar nitrile imine derived from N- methylbenzohydrazonoyl bromide hydrobromide (8). The key step for the synthesis of (3) was addition of benzyl 3-methylcarbazate (14) to ethyl N-[ chloro (phenyl) methylene ] glycinate (15b). The 4-methyl compound (4) was prepared by cycloaddition of ethyl N-( thiobenzoyl ) sarcosinate (21) with hydrazine hydrate, and the O-methyl compound (5) was prepared by reaction of sodium methoxide with 6-chloro-3-phenyl-4,5-dihydro-1,2,4-triazine (23).

  给您结果：对未报告的3-苯基二氢-1,2,4-三嗪-6(1H)-酮的四种未报告的单甲基衍生物进行了明确的合成，分别是1-甲基（2）、2-甲基（3）、4-甲基（4）和咪唑酸O-甲基衍生物（5）。通过将乙基甘氨酸酯加入从N-甲基苯甲酰肼溴水合物（8）得到的1,3-二极化腈亚胺，实现了(2)的合成的区域选择性。合成(3)的关键步骤是将苄基-3-甲基咔巴嗪（14）加入乙基N-[氯(苯基)亚甲基]甘氨酸酯（15b）。通过乙基N-(巯基苯甲酰)磺酸酯（21）与水合肼进行环加成制备了4-甲基化合物(4)，而O-甲基化合物(5)是通过钠甲醇与6-氯-3-苯基-4,5-二氢-1,2,4-三嗪（23）反应制备的。
• 3-substituted indole antiproliferative angiogenesis inhibitors
  申请人：——

  公开号：US20020091148A1

  公开（公告）日：2002-07-11

  3-Substituted indole carbohydrazides having the formula 1 are useful for inhibiting angiogenesis and cell proliferation. Also disclosed are compositions which inhibit angiogenesis and cell proliferation and methods of inhibiting angiogenesis and cancer in a mammal.

  具有下式的3-取代吲哚羰肼对抑制血管生成和细胞增殖具有用处。还揭示了抑制血管生成和细胞增殖的组合物以及抑制哺乳动物中的血管生成和癌症的方法。
• Highly selective arylation of disubstituted hydrazines by pentavalent organobismuth reagents
  作者：Olga Tšubrik、Uno Mäeorg、Ulf Ragnarsson

  DOI：10.1016/s0040-4039(02)01327-8

  日期：2002.8

  The scope of a set of recently reported hydrazine reagents has been explored with respect to arylation. Compounds of type R1NHNHCOR2 can be selectively arylated under very mild conditions using triarylbismuth diacetates.

  关于芳基化，已经研究了一组最近报道的肼试剂的范围。可以使用二乙酸三芳基铋在非常温和的条件下将R 1 NHNHCOR 2类型的化合物选择性芳基化。