6-acetoxy-2-naphthyl-α-methylacetic acid | 23981-85-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 6-acetoxy-2-naphthyl-α-methylacetic acid
• 英文别名: 6-Acetoxy-2-naphthyl-alpha-methylacetic acid；2-(6-acetyloxynaphthalen-2-yl)propanoic acid
• CAS: 23981-85-3
• 化学式: C₁₅H₁₄O₄
• 分子量: 258.274
• InChiKey: GEQSSJYINPIWGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-(6-hydroxy-2-naphthyl)propionic acid 在 乙酸酐 、 对甲苯磺酸 作用下， 以 水 为溶剂， 生成 Methyl 6-acetoxy-2-naphthyl-α-methylacetate 、 6-acetoxy-2-naphthyl-α-methylacetic acid
  参考文献：
  名称：

  2-Naphthyl acetic acid derivatives and compositions and methods thereof

  摘要：

  2-萘乙酸衍生物及其相应的酰胺、酯、羟肟酸和其盐，可选择地在乙酸基团的α-位置和/或在萘环的位置6和/或在位置1、4、7或8处进行取代，并可选择地在位置3和4处饱和，具有抗炎、镇痛、退热和止痒作用。通过给予萘乙酸衍生物进行治疗炎症、疼痛、发热和瘙痒的药物方法。用于治疗上述疾病的药物组合物，包括萘乙酸衍生物。

  公开号：

  US03978116A1

文献信息

• 6-Substituted 2-naphthyl .alpha.-substituted acetamides
  申请人：Syntex Corporation

  公开号：US03978124A1

  公开（公告）日：1976-08-31

  2-Naphthyl acetic acid derivatives and the corresponding amides, esters, hydroxamic acids and addition salts thereof, optionally substituted at the .alpha.-position on the acetic acid moiety and/or at position 6 and/or at positions 1, 4, 7 or 8 on the naphthyl ring and optionally saturated at positions 3 and 4, are anti-inflammatory, analgesic, anti-pyretic and anti-pruritic agents. A pharmaceutical method of effecting treatment of inflammation, pain, pyrexia and pruritus by the administration of naphthyl acetic acid derivatives. A pharmaceutical composition for use in the treatment of the above maladies comprising a naphthyl acetic acid derivative.

  2-萘乙酸衍生物及其相应的酰胺、酯、羟肟酸和加成盐，可在乙酸基团的α-位置和/或在萘环的1、4、6、7或8位置上选择性地取代，并可在3和4位置上选择性地饱和。它们是抗炎、镇痛、退热和止痒剂。一种通过给予萘乙酸衍生物治疗炎症、疼痛、发热和瘙痒的药物方法。一种用于治疗上述疾病的药物组合物，包括萘乙酸衍生物。
• 2-Naphthyl acetic acid derivatives
  申请人：Syntex Corporation

  公开号：US03980699A1

  公开（公告）日：1976-09-14

  2-Naphthyl acetic acid derivatives and the corresponding amides, esters, hydroxamic acids and addition salts thereof, optionally substituted at the .alpha.-position on the acetic acid moiety and/or at position 6 and/or at positions 1, 4, 7 or 8 on the naphthyl ring and optionally saturated at positions 3 and 4, are anti-inflammatory, analgesic, anti-pyretic and anti-pruritic agents. A pharmaceutical method of effecting treatment of inflammation, pain, pyrexia and pruritus by the administration of naphthyl acetic acid derivatives. A pharmaceutical composition for use in the treatment of the above maladies comprising a naphthyl acetic acid derivative.

  2-萘乙酸衍生物及其相应的酰胺、酯、羟肟酸和加成盐，可选择在乙酸基团的α-位置和/或在萘环的1、4、6、7或8号位上进行取代，可选择在3和4号位饱和，具有抗炎、镇痛、退热和止痒作用。一种通过给予萘乙酸衍生物来治疗炎症、疼痛、发热和瘙痒的药物方法。一种用于治疗上述疾病的药物组合物，包括萘乙酸衍生物。
• Anti-inflammatory, analgesic, anti-pyretic and anti-pruritic
  申请人：Syntex Corporation

  公开号：US03998966A1

  公开（公告）日：1976-12-21

  2-Naphthyl acetic acid derivatives and the corresponding amides, esters, hydroxamic acids and addition salts thereof, optionally substituted at the .alpha.-position on the acetic acid moiety and/or at position 6 and/or at positions 1, 4, 7 or 8 on the naphthyl ring and optionally saturated at positions 3 and 4, are anti-inflammatory, analgesic, anti-pyretic and anti-pruritic agents. A pharmaceutical method of effecting treatment of inflammation, pain, pyrexia and pruritus by the administration of naphthyl acetic acid derivatives. A pharmaceutical composition for use in the treatment of the above maladies comprising a naphthyl acetic acid derivative.

  2-萘乙酸衍生物及其相应的酰胺、酯、羟肟酸和加成盐，在乙酸基团的α-位和/或萘环的1、4、6、7或8位可能被取代，且在3和4位可能被饱和，具有抗炎、镇痛、退热和止痒作用。使用萘乙酸衍生物的药物治疗方法，用于治疗炎症、疼痛、发热和瘙痒。一种用于治疗上述疾病的药物组合物，包括萘乙酸衍生物。
• 6-Substituted 2-naphthyl acetic acid derivatives
  申请人：Syntex Corporation

  公开号：US04001301A1

  公开（公告）日：1977-01-04

  2-Naphthyl acetic acid derivatives and the corresponding amides, esters, hydroxamic acids and addition salts thereof, optionally substituted at the .alpha.-position on the acetic acid moiety and/or at position 6 and/or at positions 1, 4, 7 or 8 on the naphthyl ring and optionally saturated at positions 3 and 4, are anti-inflammatory, analgesic, antipyretic and anti-pruritic agents. A pharmaceutical method of effecting treatment of inflammation, pain, pyrexia and pruritus by the administration of naphthyl acetic acid derivatives. A pharmaceutical composition for use in the treatment of the above maladies comprising a naphthyl acetic acid derivative.

  2-萘乙酸衍生物及其相应的酰胺、酯、羟肟酸和加成盐，可选地在乙酸基团的α-位置和/或在萘环的1、4、6、7或8号位置取代，并可选地在3号和4号位置饱和，具有抗炎、镇痛、退热和抗瘙痒作用。一种通过给予萘乙酸衍生物治疗炎症、疼痛、发热和瘙痒的药物方法。一种用于治疗上述疾病的药物组合物，包括萘乙酸衍生物。
• 2-Naphthylacetic acid derivatives and compositions and methods thereof
  申请人：Syntex Corporation

  公开号：US04051233A1

  公开（公告）日：1977-09-27

  2-Naphthyl acetic acid derivatives and the corresponding amides, esters, hydroxamic acids and addition salts thereof, optionally substituted at the .alpha.-position on the acetic acid moiety and/or at position 6 and/or at positions 1, 4, 7 or 8 on the naphthyl ring and optionally saturated at positions 3 and 4, are anti-inflammatory, analgesic, anti-pyretic and anti-pruritic agents. A pharmaceutical method of effecting treatment of inflammation, pain, pyrexia and pruritus by the administration of naphthyl acetic acid derivatives. A pharmaceutical composition for use in the treatment of the above maladies comprising a naphthyl acetic acid derivative.

  2-萘乙酸衍生物及其相应的酰胺、酯、羟肟酸和加成盐，可选择性地在乙酸基团的α-位置和/或萘环的1、4、6、7或8位置进行取代，并可选择性地在3和4位置饱和，具有抗炎、镇痛、退热和抗瘙痒作用。一种利用萘乙酸衍生物进行治疗炎症、疼痛、发热和瘙痒的药物方法。一种用于治疗上述疾病的药物组合物，包括萘乙酸衍生物。