matridin-15-one | 6783-60-4

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 羽扇豆生物碱
• 英文名称: matridin-15-one
• 英文别名: leontine；Leontin；(1S,2S,9R,17S)-7,13-diazatetracyclo[7.7.1.02,7.013,17]heptadecan-6-one
• CAS: 6783-60-4
• 化学式: C₁₅H₂₄N₂O
• 分子量: 248.368
• InChiKey: ZSBXGIUJOOQZMP-OSFYFWSMSA-N

物化性质

• 熔点：
  107～108℃
• 沸点：
  190-210 °C(Press: 7 Torr)
• 密度：
  1.16±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Method for the preparation of technetium or rhenium complex for radiopharmaceuticals
  申请人：——

  公开号：US20030228255A1

  公开（公告）日：2003-12-11

  The present invention relates to a method of preparing technetium or rhenium complex for radiopharmaceuticals, through reaction of pertechnetate or perrhenate with a ligand in the presence of a reducing agent, wherein the reducing agent is a borohydride exchange resin (BER) . The borohydride exchange resin of the present invention has advantages of being stable in a wide range of Ph, including acidic or alkaline condition(Ph 2˜14) and thus being applicable to biological materials as well as being easily removable through filtration when being administrated. Also since the radiolabelled complex is produced under conditions milder than those required for the conventional reducing agents as well as has high radiochemical purity and high labeling efficiency, the conventional reducing agents can be replaced by the BER of the present invention.

  本发明涉及一种制备用于放射性药物的钼或锝络合物的方法，通过在还原剂存在下，将过钼酸盐或过锝酸盐与配体反应，其中还原剂是硼氢化物交换树脂（BER）。本发明的硼氢化物交换树脂具有在广泛的pH范围内稳定，包括酸性或碱性条件（pH 2˜14），因此适用于生物材料，并且在被管理时易于通过过滤去除。此外，由于放射性标记的络合物是在比传统还原剂所需条件更温和的条件下产生的，具有高放射化学纯度和高标记效率，因此传统还原剂可以被本发明的BER所取代。
• Method of preparing rhenium-tricarbonyl complex and its precursor
  申请人：Park Sang Hyun

  公开号：US20070140959A1

  公开（公告）日：2007-06-21

  Disclosed herein is a method of preparing a 188 Re-tricarbonyl complex for radiopharmaceutical use and of preparing a precursor thereof, and a contrast agent using the same. Particularly, this invention provides a method of preparing a 188 Re-tricarbonyl precursor by reacting perrhenate with borane-ammonia (BH 3 .NH 3 ), potassium boranocarbonate (K 2 [H 3 BCO 2 ]) and phosphate in the presence of borohydride exchange resin as a reducing agent, and a method of preparing a 188 Re-tricarbonyl complex by reacting the 188 Re-tricarbonyl precursor with a ligand. According to the method of this invention, the borohydride exchange resin is used as a reducing agent and as an anion scavenger, thereby obtaining the 188 Re-tricarbonyl precursor and complex having high radiolabeling yield and high purity. In addition, the 188 Re-tricarbonyl complex can be used as a contrast agent having excellent plasma stability.

  本文公开了一种制备用于放射性药物的188Re三羰基配合物及其前体的方法，以及使用该方法制备对比剂的方法。特别地，本发明提供了一种通过将钨酸根与硼氢化铵（BH3.NH3）、碳酸硼酸钾（K2[H3BCO2]）和磷酸在硼氢化物交换树脂存在下作为还原剂反应来制备188Re三羰基前体的方法，以及通过将188Re三羰基前体与配体反应来制备188Re三羰基配合物的方法。根据本发明的方法，使用硼氢化物交换树脂作为还原剂和阴离子清除剂，从而获得具有高放射性标记收率和高纯度的188Re三羰基前体和配合物。此外，188Re三羰基配合物可用作具有优异血浆稳定性的对比剂。
• Method of preparing rhenium-188 tricarbonyl triaqua complex
  申请人：Korea Atomic Energy Research Institute

  公开号：EP1797904A1

  公开（公告）日：2007-06-20

  Disclosed herein is a method of preparing a 188Retricarbonyl complex for radiopharmaceutical use and of preparing a precursor thereof, and a contrast agent using the same. Particularly, this invention provides a method of preparing a 188Re-tricarbonyl precursor by reacting perrhenate with borane·ammonia (BH3·NH3), potassium boranocarbonate (K2[H3BCO2]) and phosphate in the presence of borohydride exchange resin as a reducing agent, and a method of preparing a 188Re-tricarbonyl complex by reacting the 188Re-tricarbonyl precursor with a ligand. According to the method of this invention, the borohydride exchange resin is used as a reducing agent and as an anion scavenger, thereby obtaining the 188Re-tricarbonyl precursor and complex having high radiolabeling yield and high purity. In addition, the 188Re-tricarbonyl complex can be used as a contrast agent having excellent plasma stability.

  本发明公开了一种制备放射性药物用 188R 三羰基络合物及其前体的方法，以及使用该方法制备造影剂的方法。特别是，本发明提供了一种制备 188Re 三羰基前体的方法，该方法是在硼氢化物交换树脂作为还原剂存在的情况下，通过过铼酸盐与硼烷-氨（BH3-NH3）、硼碳酸钾（K2[H3BCO2]）和磷酸盐反应制备 188Re 三羰基前体，以及通过 188Re 三羰基前体与配体反应制备 188Re 三羰基络合物。根据本发明的方法，使用硼氢化交换树脂作为还原剂和阴离子清除剂，从而获得具有高放射性标记产率和高纯度的 188Re-tricarbonyl 前体和复合物。此外，188Re-三羰基复合物可用作造影剂，具有极佳的等离子稳定性。
• METHOD FOR THE PREPARATION OF PICKLED POTATO STRINGS
  申请人：HZPC Holland B.V.

  公开号：EP3415015A1

  公开（公告）日：2018-12-19

  Described is a method for the preparation of pickled potato strings, comprising the steps of providing potatoes, cutting the potatoes in strings having a cross-sectional area of 25 mm2 or less, heating the potato strings, blast chilling the heated potato strings and incubating the blast chilled tomato strings in a liquid pickling medium having a pH of between 3 and 4.5 at elevated temperature.

  描述了一种制备腌制马铃薯串的方法，包括以下步骤：提供马铃薯，将马铃薯切成横截面积为 25 平方毫米或更小的马铃薯串，加热马铃薯串，对加热的马铃薯串进行鼓风冷却，并将鼓风冷却后的番茄串在 pH 值介于 3 和 4.5 之间的液体腌制介质中在高温下培养。
• Method for the preparation of instant stir-fried potato strings
  申请人：HZPC HOLLAND B.V.

  公开号：US10638781B2

  公开（公告）日：2020-05-05

  Described is a method for the preparation of instant stir-fried potato strings having a refrigerated shelf life before stir-frying, comprising the steps of providing potatoes, cutting the potatoes in strings having a cross-sectional area of 25 mm2 or less, heating the potato strings, blast chilling the heated potato strings and packaging and storing the potato strings at a refrigerated temperature, the method being free of contacting the potato strings with oil.

  描述了一种在炒制前具有冷藏保质期的速炒马铃薯串的制备方法，包括以下步骤：提供马铃薯，将马铃薯切成横截面积为 25 mm2 或更小的马铃薯串，加热马铃薯串，对加热后的马铃薯串进行鼓风冷却，以及在冷藏温度下包装和储存马铃薯串，该方法无需将马铃薯串与油接触。