N-[2-[乙基(3-甲基苯基)氨基]乙基]-乙酰胺 | 42816-33-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-[2-[乙基(3-甲基苯基)氨基]乙基]-乙酰胺
• 英文名称: N-ethyl-N-(3-methylphenyl)-N'-ethanoylethylenediamine
• 英文别名: N-ethyl-N-(3-methylphenyl)-N'-acetylethylenediamine；Acetamide, N-[2-[ethyl(3-methylphenyl)amino]ethyl]-；N-[2-(N-ethyl-3-methylanilino)ethyl]acetamide
• CAS: 42816-33-1
• 化学式: C₁₃H₂₀N₂O
• 分子量: 220.315
• InChiKey: ZPEDSBOBSNNATM-UHFFFAOYSA-N

物化性质

• 沸点：
  412.3±28.0 °C(Predicted)
• 密度：
  1.021±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• METHOD FOR MEASURING TRIGLYCERIDE IN LOW-DENSITY LIPOPROTEIN AND KIT FOR MEASUREMENT
  申请人：Katayama Yuki

  公开号：US20090226944A1

  公开（公告）日：2009-09-10

  The present invention provides a method for a simple and accurate measurement of triglycerides in low-density lipoprotein in a sample comprising performing the following steps sequentially: (i) a step of generating free glycerol by allowing lipoprotein lipase to act on a sample, in an aqueous medium comprising the sample and a specific surfactant such as polyoxyethylene polyoxyalkylene polycyclic phenyl ether; (ii) a step of removing free glycerol present in the reaction solution of the above step (i); (iii) a step of generating free glycerol by allowing lipoprotein lipase to act on the reaction solution from which free glycerol has been removed in step (ii), in the presence of a specific surfactant such as polyoxyethylene polyoxyalkylene alkyl ether; and (iv) a step of measuring free glycerol generated in step (iii), and a kit used for the method.

  本发明提供了一种简单准确地测量样品中低密度脂蛋白中甘油三酯的方法，包括按照以下步骤顺序进行：(i)在包括样品和特定表面活性剂（例如聚氧乙烯聚氧烷基多环苯醚）的水介质中，使脂蛋白酯酶作用于样品，生成游离甘油；(ii)去除步骤(i)中反应溶液中存在的游离甘油；(iii)在去除步骤(ii)中的游离甘油的反应溶液中，使脂蛋白酯酶作用于特定表面活性剂（例如聚氧乙烯聚氧烷基烷基醚）的存在下，生成游离甘油；(iv)测量步骤(iii)中生成的游离甘油，以及用于该方法的试剂盒。
• Test composition for the determination of triglycerides and its use
  申请人：KYOWA HAKKO KOGYO CO., LTD

  公开号：EP0010296A1

  公开（公告）日：1980-04-30

  Triglycerides in a sample are quantitatively determined using a test composition having a system for converting the triglycerides to fatty acids and glycerol, a system for oxidizing the glycerol, and a system for determining the amount of oxygen consumed or the amount of hydrogen peroxide or glyceraldehyde formed in the oxidation of the glycerol.

  样品中甘油三酯的定量测定使用的测试组合物具有将甘油三酯转化为脂肪酸和甘油的系统、氧化甘油的系统以及测定甘油氧化过程中消耗的氧气量或形成的过氧化氢或甘油醛量的系统。
• Method and test composition for determination of hydrogen peroxide
  申请人：Kyowa Medex Co. Ltd.

  公开号：EP0124287A2

  公开（公告）日：1984-11-07

  Disclosed is a method for the colorimetric determination of hydrogen peroxide in a sample by reacting a particular chromogen with the hydrogen peroxide in the presence of peroxidase and measuring the absorbancy of the reaction solution in the visible or near inflared ray region. Also disclosed is a test composition for carrying out the determination. The novel chromogens are represented by the formulae

  本发明公开了一种用比色法测定样品中过氧化氢的方法，该方法是在过氧化物酶的存在下，使一种特定的发色剂与过氧化氢反应，并测量反应溶液在可见光或近红外线区域的吸光度。 本发明还公开了一种用于进行该测定的测试组合物。 新型发色剂由以下式子表示
• Method for the determination of Leucine Aminopeptidase (LAP)
  申请人：Kyowa Medex Co. Ltd.

  公开号：EP0152274A2

  公开（公告）日：1985-08-21

  The present invention provides a method for the determination of leucine-aminopeptidase (hereinafter referred to as LAP) activity or Y-glutamyltranspeptidase (hereinafter referred to as γ-GTP) activity in a sample which comprises converting the substrate for the enzyme to be determined represented by the general formula (I): wherein Z represents (CH3)2CHCH2CH(NH2)-or(NH2)(COOH) CHCH2CH2-, R, represents hydrogen, alkyl or substituted alkyl, R2 represents alkylene or hydroxyalkylene, R3 and R4 are the same or different and represents hydrogen, halogeno, nitro, hydroxyl, sulfo, carboxyl, alkyl, and alkoxy, and salts thereof into the compound represented by the general formula (II): wherein R,, R2, R3 and R4 have the same meanings as defined above [hereinafter referred to as compound (II)] by the action of LAP or y-GTP, (a) reacting the compound (II) with a chromogen to form a pigment or (b) converting the compound (II)-into diazonium salt and reacting the diazonium salt with coupling agent to form azo dye, and measuring the absorption of the colored reaction solution.

  本发明提供了一种测定样品中亮氨酸-氨基肽酶（以下简称 LAP）活性或 Y-谷氨酰转肽酶（以下简称 γ-GTP）活性的方法，该方法包括将通式 (I) 所代表的待测定酶的底物转化： 其中 Z 代表(CH3)2CHCH2CH(NH2)-或(NH2)(COOH) CHCH2CH2-，R 代表氢、烷基或取代的烷基，R2 代表亚烷基或羟基亚烷基，R3 和 R4 相同或不同并代表氢、卤素、硝基、羟基、磺基、羧基、烷基和烷氧基，以及它们的盐： 其中 R、R2、R3 和 R4 的含义与上述定义相同[以下简称化合物（II）]，在 LAP 或 y-GTP 的作用下，(a) 使化合物（II）与发色剂反应生成色素，或 (b) 将化合物（II）转化为重氮盐，并使重氮盐与偶联剂反应生成偶氮染料，然后测量有色反应溶液的吸收率。
• Method of measuring NADH and NADPH
  申请人：SANWA KAGAKU KENKYUSHO CO., LTD.

  公开号：EP0530732A1

  公开（公告）日：1993-03-10

  There is disclosed a method of measuring NADH or NADPH in a body fluid such as serum for quantitatively measuring a biochemical substance or activity of enzyme therein. According to the method, steps of generating hydrogen peroxide by an action of NADH or NADPH oxidase and measuring the hydrogen peroxide by a chromogenic reaction are concurrently carried out. As the color developing reagent of oxidative coupling reaction, peroxidase, a substance selected from aniline and its derivative, and a substance selected from 3-methyl-2-benzothiazolinone hydrazone and its derivative are employed in combination. If necessary, an enzyme of superoxide dismutase is coexisted in reaction system.

  本发明公开了一种测量血清等体液中 NADH 或 NADPH 的方法，用于定量测量其中的生化物质或酶的活性。根据该方法，通过 NADH 或 NADPH 氧化酶的作用生成过氧化氢和通过显色反应测量过氧化氢的步骤同时进行。作为氧化偶联反应的显色试剂，过氧化物酶、一种选自苯胺及其衍生物的物质和一种选自 3-甲基-2-苯并噻唑啉酮腙及其衍生物的物质被混合使用。必要时，反应体系中还可同时加入超氧化物歧化酶。