N-[κ-maleimidoundecanoyloxy]sulfosuccinimide ester | 220935-13-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: N-[κ-maleimidoundecanoyloxy]sulfosuccinimide ester
• 英文别名: Sulfo-kmus；1-[11-(2,5-dioxopyrrol-1-yl)undecanoyloxy]-2,5-dioxopyrrolidine-3-sulfonic acid
• CAS: 220935-13-7
• 化学式: C₁₉H₂₆N₂O₉S
• 分子量: 458.489
• InChiKey: VIVFZHFDSHRYIW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  31
• 可旋转键数：
  14
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  164
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  anti-epidermal growth factor receptor (EGFR) monoclonal antibody 、 N-[κ-maleimidoundecanoyloxy]sulfosuccinimide ester 生成 anti-EGFR monoclonal antibody; coupled with N-[κ-maleimidoundecanoyloxy]sulfosuccinimide ester
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Clinically intelligent diagnostic devices and methods
  申请人：Intelligent Medical Devices LLC

  公开号：EP2202520A1

  公开（公告）日：2010-06-30

  The present invention is related to a method of determining a cause of one or more medical symptoms exhibited by a subject, the method comprising: (a) obtaining a biological sample from the subject; (b) obtaining an array of different probes or different sets of probes, wherein each probe or set of probes selectively interacts with a target associated with a different known cause of the one or more medical symptoms; (c) applying the biological sample to the probes in the array under conditions that enable all of the probes to selectively interact with any targets in the biological sample; (d) detecting interactions; and (e) analyzing interactions to determine a cause of the one or more medical symptoms.

  本发明涉及一种确定受试者表现出的一种或多种医学症状的原因的方法，该方法包括 (a) 获取受试者的生物样本； (b) 获得由不同探针或不同探针组组成的阵列，其中每个探针或探针组选择性地与与一个或多个医学症状的不同已知病因相关的目标相互作用； (c) 在使所有探针都能选择性地与生物样本中的任何靶点相互作用的条件下，将生物样本施加到阵列中的探针上； (d) 检测相互作用；以及 (e) 分析相互作用，以确定一种或多种病症的病因。
• METHOD FOR DETECTION OF PNEUMOCOCCUS
  申请人：Otsuka Pharmaceutical Co., Ltd.

  公开号：EP2261666A1

  公开（公告）日：2010-12-15

  To provide an immunological detection method which can detect or quantify a pneumococcal antigen in a sample derived from a living body conveniently, rapidly, and with high sensitivity, and an antibody for use in the method. The present invention provides an antibody which specifically recognizes a pneumococcal F-antigen; a method for detecting or quantitating a pneumococcal antigen, characterized in that the method detects or quantitates a pneumococcal F-antigen in a sample derived from a living body through immunological assay employing the antibody; and a kit for detecting a pneumococcal antigen, the kit containing the antibody.

  提供一种能方便、快速、高灵敏度地检测或定量来自活体样本中的肺炎球菌抗原的免疫学检测方法，以及用于该方法的抗体。本发明提供了一种特异性识别肺炎球菌 F 抗原的抗体；一种检测或定量肺炎球菌抗原的方法，其特征在于该方法通过使用该抗体进行免疫学检测，检测或定量来自活体样本中的肺炎球菌 F 抗原；以及一种检测肺炎球菌抗原的试剂盒，该试剂盒含有该抗体。
• Clinically intelligent diagnostic devices and mehtods
  申请人：——

  公开号：US20020095073A1

  公开（公告）日：2002-07-18

  The invention relates to the clinically intelligent design of diagnostic devices (such as microarrays) and methods of making and using such devices in differential diagnoses of specific clinical symptoms or sets of symptoms. In one aspect, the devices include various probes used to perform parallel screening of a number of analytes. The probes are clustered on the devices based on known clinical presentations of symptoms associated with specific diseases and disorders.

  本发明涉及诊断设备（如微阵列）的临床智能设计，以及制作和使用此类设备对特定临床症状或症状集进行鉴别诊断的方法。在一个方面，这些设备包括各种探针，用于对许多分析物进行平行筛选。这些探针是根据与特定疾病和失调相关的症状的已知临床表现在设备上聚类的。
• Means for eliciting an immune response and a method therefor
  申请人：——

  公开号：US20040235771A1

  公开（公告）日：2004-11-25

  A means to elicit a cytotoxic immune response as a result of injecting antigen encoding expression constructs. Minimalistic expression constructs are used that comprise a promoter, a coding sequence and a terminator, and hairpin-shaped oligonucleotides on their ends, to the loop of which cationic peptides are covalently attached. These peptide-coupled expression constructs lead to a cell mediated response type after intradermal injection. The use of a DNA expression construct operable in eucaryotic cells for making a vaccine for intradermal injection to elicit a type 1 cell mediated immune mediated immune response is described.

  一种通过注射抗原编码表达构建物引起细胞毒性免疫反应的方法。使用的极简表达构建物包括一个启动子、一个编码序列和一个终止子，其末端是发夹状寡核苷酸，阳离子肽共价连接在发夹状寡核苷酸的环上。这些肽耦合表达构建体在皮内注射后可产生细胞介导的反应类型。本文介绍了如何使用可在真核细胞中操作的 DNA 表达构建体来制造疫苗，用于皮内注射，以引起 1 型细胞介导的免疫应答。
• CLINICALLY INTELLIGENT DIAGNOSTIC DEVICES AND METHODS
  申请人：Intelligent Medical Devices LLC

  公开号：EP1397679A2

  公开（公告）日：2004-03-17