2-benzamido-6-tert-butyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid | 407587-13-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-benzamido-6-tert-butyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid
• 英文别名: 2-benzamido-6-tert-butyl-4,5,6,7-tetrahydrobenzothiophene-3-carboxylic acid；2-Benzamido-6-tert-butyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid
• CAS: 407587-13-7
• 化学式: C₂₀H₂₃NO₃S
• 分子量: 357.474
• InChiKey: BOXKQUNGQKROGE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  94.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] FUSED THIOPHENE DERIVATIVES AND THEIR USES<br/>[FR] DÉRIVÉS DE THIOPHÈNE CONDENSÉS ET LEURS UTILISATIONS
  申请人：ENYO PHARMA

  公开号：WO2019154949A1

  公开（公告）日：2019-08-15

  The present invention relates to a new class of fused thiophene derivatives and their uses for treating diseases such as infection, cancer, metabolic diseases, cardiovascular diseases, iron storage disorders and inflammatory disorders.

  本发明涉及一类新的融合噻吩衍生物，以及它们在治疗感染、癌症、代谢性疾病、心血管疾病、铁储存障碍和炎症性疾病方面的用途。
• INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS
  申请人：Verkman Alan S.

  公开号：US20110015239A1

  公开（公告）日：2011-01-20

  Provided herein are methods for identifying compounds that are inhibitors of a calcium-activated chloride channel. Aminothiophene and aminothiazole compounds, and compositions comprising these compounds, described herein that inhibit efflux of chloride through a calcium-activated chloride channel are useful for treating diseases, disorders, and sequalae of diseases, disorders, and conditions that are associated with aberrantly increased chloride and fluid secretion, for example, secretory diarrhea.
• FUSED THIOPHENE DERIVATIVES AND THEIR USES
  申请人：ENYO PHARMA

  公开号：US20200369682A1

  公开（公告）日：2020-11-26

  The present invention relates to a new class of fused thiophene derivatives and their uses for treating diseases such as infection, cancer, metabolic diseases, cardiovascular diseases, iron storage disorders and inflammatory disorders.
• US9789095B2
  申请人：——

  公开号：US9789095B2

  公开（公告）日：2017-10-17
• [EN] INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS<br/>[FR] INHIBITEURS DES CANAUX CHLORURE ACTIVES PAR LE CALCIUM
  申请人：UNIV CALIFORNIA

  公开号：WO2009079373A2

  公开（公告）日：2009-06-25

  Provided herein are methods for identifying compounds that are inhibitors of a calcium-activated chloride channel. Aminothiophene and aminothiazole compounds, and compositions comprising these compounds, described herein that inhibit efflux of chloride through a calcium-activated chloride channel are useful for treating diseases, disorders, and sequelae of diseases, disorders, and conditions that are associated with aberrantly increased chloride and fluid secretion, for example, secretory diarrhea.