n-(8-Maleimidocapryloxy)succinimide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: n-(8-Maleimidocapryloxy)succinimide
• 英文别名: (2,5-dioxopyrrolidin-1-yl) 8-(2,5-dioxopyrrol-1-yl)octanoate
• 化学式: C₁₆H₂₀N₂O₆
• 分子量: 336.34
• InChiKey: AXYCKCSVVUIIMW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  24
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  101
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Non-specific reaction inhibitor, method for inhibiting non-specific reaction, and kit
  申请人：Okamura Yoshikazu

  公开号：US11125742B2

  公开（公告）日：2021-09-21

  Provided is a non-specific reaction inhibitor for achieving the accurate detection and quantitation of a trace component (a target substance) contained in a sample, in an immunoassay, by simply and effectively inhibiting a non-specific reaction associated with the measurement. The non-specific reaction inhibitor comprises a substance of the formula I: wherein R1 and R2 together form a double bond between carbons, to which they are respectively bonded directly, or R1 is a hydrogen atom and R2 is a group formed by removing H from an SH-group-containing compound, B is a support, and L is a spacer arm portion.

  提供的是一种非特异性反应抑制剂，用于通过简单有效地抑制与测量相关的非特异性反应，在免疫测定中实现对样品中微量组分（目标物质）的准确检测和定量。该非特异性反应抑制剂包括式I的物质：其中R1和R2共同形成碳之间的双键，它们分别直接连接在碳上，或者R1是氢原子，R2是从含有SH基团的化合物中去除H形成的基团，B是支持体，L是空间臂部分。
• Hydrogels and hydrogel arrays made from reactive prepolymers crosslinked by [2 + 2] cycloaddition
  申请人：Motorola, Inc.

  公开号：US20020115740A1

  公开（公告）日：2002-08-22

  Reactive prepolymers incorporating [2+2] photoreactive sites are synthesized. Upon exposure to UV light, these prepolymers undergo [2+2] cycloaddition to crosslink. When crosslinked, the reactive prepolymers form a hydrogel. Selective hydrogel formation is provided through selective exposure of the reactive prepolymer to UV light. Supports and other molecules may be attached or incorporated into the hydrogel through [2+2] cycloaddition with uncrosslinked [2+2] photoreactive sites present in the hydrogel.

  合成了包含【2+2】光反应位点的反应性预聚物。在紫外光的照射下，这些预聚物会发生【2+2】环加成反应，形成交联物。交联后，反应性预聚物形成了一种水凝胶。通过选择性地将反应性预聚物暴露在紫外光下，可以提供选择性水凝胶形成。支撑物和其他分子可以通过与水凝胶中存在未交联的【2+2】光反应位点的环加成反应来附着或纳入到水凝胶中。
• POLYMERIC COMPOSITIONS AND METHODS OF MAKING AND USING THEREOF
  申请人：Kiser Patrick F.

  公开号：US20090220607A1

  公开（公告）日：2009-09-03

  Described herein are polymeric compositions having a polymer residue and a crosslinker residue, wherein the polymer residue is bonded to the crosslinker residue with a moiety formed from a cycloaddition reaction. Also, described are methods of making and using such polymeric compositions.

  本文描述了一种具有聚合物残留物和交联剂残留物的聚合物组合物，其中聚合物残留物与交联剂残留物通过来自环加成反应形成的一个分子结合在一起。同时，还描述了制备和使用这种聚合物组合物的方法。
• PYRAZOLE-BASED CYANINE DYE
  申请人：Date Mutsuhiro

  公开号：US20090069546A1

  公开（公告）日：2009-03-12

  Problem Provided is a novel cyanine dye derivative with a pyrazole skeleton and an indole skeleton, having high sensitivity performance in a shorter wavelength region as compared with a conventional optical system, and showing high water solubility. Solution The invention provides (1) a compound represented by the following general formula [50] and a salt thereof: [wherein R 1 to R 6 each independently represent a substituted or unsubstituted alkyl group which may have an amide bond; R 7 to R 10 each independently represent alkyl group, alkenyl group, alkynyl group, aryl group, alkoxy group, aryloxy group, alkylthio group, arylthio group, alkylsulfonyl group, arylsulfonyl group, carbamoyl group, sulfamoyl group, ureido group or amino group, those groups being able to have substituents; a group represented by the general formula [2]: —COOR 12 [2] (wherein R 12 represents hydrogen atom, C 1 to C 10 alkyl group, alkali metal atom, organic ammonium ion, ammonium ion or anion); a group represented by the general formula [3]: —SO 3 R 13 [3] (wherein R 13 represents hydrogen atom, alkali metal atom, organic ammonium ion, ammonium ion or anion), halogen atom, aromatic heterocyclic thio group, hydrogen atom, hydroxyl group, cyano group, formyl group, thiol group or nitro group; R 11 represents hydrogen atom, or alkyl group, alkenyl group, alkynyl group or aryl group, those groups being able to have substituents; and n represents an integer of from 0 to 3, provided that any of R 1 and R 2 , R 4 and R 5 , R 1 and R 6 , and R 2 and R 4 may form a bivalent group with a group selected from —O— group, —S— group, —COO— group and groups represented by the general formulae [52] to [54]: (wherein R 50 represents hydrogen atom, alkyl group, alkenyl group or aryl group, those groups being able to have substituents), and substituted or unsubstituted alkylene group; and in the case where said bivalent group is formed, at least one of R 1 to R 11 , along with the bivalent group formed by any of R 1 and R 2 , R 4 and R 5 , R 1 and R 6 , and R 2 and R 4 , has the group represented by the general formula [2], the group represented by the general formula [3], amino group, hydroxyl group, thiol group or formyl group; and in the case where said bivalent group is not formed, at least one of R 1 to R 11 has the group represented by the general formula [2], the group represented by the general formula [3], amino group, hydroxyl group, thiol group or formyl group]; (2) a labeled compound obtained by subjecting the above compound to direct or indirect binding to a substance to be labeled, and (3) a method for labeling a substance to be labeled, comprising subjecting the above compound to direct or indirect binding to the substance to be labeled.

  问题提供了一种具有吡唑骨架和吲哚骨架的新型靛烯染料衍生物，与传统光学系统相比，在更短的波长区域具有高灵敏度性能，并且具有高水溶性。 解决方案提供了(1)以下一般式[50]及其盐所代表的化合物：[其中R1到R6各自独立地代表取代或未取代的烷基，该烷基可能具有酰胺键；R7到R10各自独立地代表烷基、烯基、炔基、芳基、烷氧基、芳氧基、烷硫基、芳硫基、烷磺酰基、芳基磺酰基、氨基甲酰基、磺酰胺基、脲基或氨基，这些基团能够具有取代基；由以下一般式[2]所代表的基团：—COOR12[2]（其中R12代表氢原子、C1到C10烷基、碱金属离子、有机铵离子、铵离子或阴离子）；由以下一般式[3]所代表的基团：—SO3R13[3]（其中R13代表氢原子、碱金属离子、有机铵离子、铵离子或阴离子）、卤素原子、芳基杂环硫基、氢原子、羟基、氰基、甲酰基、硫醇基或硝基；R11代表氢原子、或烷基、烯基、炔基或芳基，这些基团能够具有取代基；n代表从0到3的整数，前提是R1和R2、R4和R5、R1和R6以及R2和R4中的任何一个可以与选择自—O—基团、—S—基团、—COO—基团和由以下一般式[52]至[54]所代表的基团之一（其中R50代表氢原子、烷基、烯基或芳基，这些基团能够具有取代基）、取代或未取代的烷基烯基，形成双价基团；在形成双价基团的情况下，R1到R11中至少有一个与由R1和R2、R4和R5、R1和R6以及R2和R4中的任何一个形成的双价基团一起，具有由以下一般式[2]和[3]所代表的基团、氨基、羟基、硫醇基或甲酰基；在未形成双价基团的情况下，R1到R11中至少有一个具有由以下一般式[2]和[3]所代表的基团、氨基、羟基、硫醇基或甲酰基]；(2)通过将上述化合物直接或间接结合到待标记物质上而获得的标记化合物，以及(3)用于标记待标记物质的方法，包括将上述化合物直接或间接地结合到待标记物质上。
• AGENT FOR TARGETING DRUG TO CEREBRAL NEURON
  申请人：Kagoshima University

  公开号：EP1985311A1

  公开（公告）日：2008-10-29

  The present invention relates to targeting agents of drugs, more specifically, to targeting agents that cause drugs to be incorporated into brain neurons. The present invention further relates to medicines comprising the targeting agents and drugs. The present invention also relates to a method for targeting drugs to brain neurons.

  本发明涉及药物的靶向制剂，更具体地说，涉及可使药物与脑神经元结合的靶向制剂。本发明还涉及由靶向制剂和药物组成的药物。本发明还涉及一种将药物靶向脑神经元的方法。