4-methyl-5-p-tolyl-[1,2]dithiole-3-thione | 114841-67-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-methyl-5-p-tolyl-[1,2]dithiole-3-thione
• 英文别名: 4-methyl-5-p-tolyl-[1,2]dithiol-3-thione；4-Methyl-5-p-tolyl-[1,2]dithiol-3-thion；4-Methyl-5-(4-methylphenyl)dithiole-3-thione；4-methyl-5-(4-methylphenyl)dithiole-3-thione
• CAS: 114841-67-7
• 化学式: C₁₁H₁₀S₃
• 分子量: 238.398
• InChiKey: VGMHAGIYDQQLSD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  82.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-methyl-5-p-tolyl-[1,2]dithiole-3-thione 、 N-苯基苯羰基亚肼酰氯 以 xylene 为溶剂， 生成 2-(3,5-diphenyl-3H-[1,3,4]thiadiazol-2-ylidene)-1-p-tolyl-propane-1-thione
  参考文献：
  名称：

  Maguet,M. et al., Bulletin de la Societe Chimique de France, 1970, p. 1503 - 1509

  摘要：

  DOI：
• 作为产物：
  描述：

  2,4'-二甲基苯丙酮 在 联苯 、 phosphorous (V) sulfide 、 sulfur 作用下， 生成 4-methyl-5-p-tolyl-[1,2]dithiole-3-thione
  参考文献：
  名称：

  Legrand; Lozac'h, Bulletin de la Societe Chimique de France, 1956, p. 1130,1133

  摘要：

  DOI：

文献信息

• COMPOSITIONS AND METHODS FOR MODULATING THE IMMUNE SYSTEM
  申请人：Prendergast Patrick T.

  公开号：US20120196825A1

  公开（公告）日：2012-08-02

  The present invention provides methods and compositions for the prophylaxis of blood cell disorders such as neutropenia, thrombocytopenia, lymphocytopenia, and anaemia. The invention provides methods wherein compositions comprising at least one cytokinin compound are administered either therapeutically or prophylactically. The invention further has utility in methods of DNA repair.
• Compositions and Methods for Preventing and Treating Mucositis and Weight Loss
  申请人：Cascade Estate Ltd.

  公开号：US20130259930A1

  公开（公告）日：2013-10-03

  Pharmaceutical compositions comprising 5-[2-pyrazinyl]-4-methyl-1,2-3-thione or an analogue, derivative, metabolite, prodrug, solvate or a pharmaceutically acceptable salt thereof; and a pharmaceutical carrier, which promotes association with the outer wall of a subject's digestive tract are described as well as their uses in treating and preventing mucositis and cachexia.
• COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING MUCOSITIS AND WEIGHT LOSS
  申请人：ST IP Holding AG

  公开号：US20150031701A1

  公开（公告）日：2015-01-29

  Pharmaceutical compositions comprising 5-[2-pyrazinyl]-4-methyl-1,2-3-thione or an analogue, derivative, metabolite, prodrug, solvate or a pharmaceutically acceptable salt thereof; and a pharmaceutical carrier, which promotes association with the outer wall of a subject's digestive tract are described as well as their uses in treating and preventing mucositis and cachexia.