N-[2-((2S,4aR,5aR,8S,9aS,9bS)-2,8-Diphenyl-hexahydro-bis[1,3]dioxino[5,4-b;4',5'-d]pyrrol-5-yl)-2-oxo-ethyl]-4-methyl-N-(3-oxo-3-phenyl-propyl)-benzenesulfonamide | 179093-10-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[2-((2S,4aR,5aR,8S,9aS,9bS)-2,8-Diphenyl-hexahydro-bis[1,3]dioxino[5,4-b;4',5'-d]pyrrol-5-yl)-2-oxo-ethyl]-4-methyl-N-(3-oxo-3-phenyl-propyl)-benzenesulfonamide
• 英文别名: N-[2-[(1S,2S,4S,7R,9R,12S)-4,12-diphenyl-3,5,11,13-tetraoxa-8-azatricyclo[7.4.0.02,7]tridecan-8-yl]-2-oxoethyl]-4-methyl-N-(3-oxo-3-phenylpropyl)benzenesulfonamide
• CAS: 179093-10-8
• 化学式: C₃₈H₃₈N₂O₈S
• 分子量: 682.794
• InChiKey: LZZXXUBTUTVPGV-HRBSCIILSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  49
• 可旋转键数：
  10
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  120
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  N-[2-((2S,4aR,5aR,8S,9aS,9bS)-2,8-Diphenyl-hexahydro-bis[1,3]dioxino[5,4-b;4',5'-d]pyrrol-5-yl)-2-oxo-ethyl]-4-methyl-N-(3-oxo-3-phenyl-propyl)-benzenesulfonamide 以70%的产率得到((2S,4aR,5aR,8S,9aS,9bS)-2,8-Diphenyl-hexahydro-bis[1,3]dioxino[5,4-b;4',5'-d]pyrrol-5-yl)-[(2S,3S)-3-hydroxy-3-phenyl-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-methanone
  参考文献：
  名称：

  Synthesis of the chiral auxiliary 1,3:4,6-di-O-benzylidene-2,5-dideoxy-2,5-imino-D-iditol

  摘要：

  L-Mannitol 5, the precursor of the the C-2-symmetrical auxiliary 3B, was prepared in high yield by heterogeneous reduction of L-mannonic-gamma-lactone 4. The auxiliary 3B could be used for stereoselective photochemical synthesis of the L-proline derivative 2B. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0957-4166(96)00137-1
• 作为产物：
  描述：

  (3-Oxo-3-phenyl-propylamino)-acetic acid benzyl ester 在 吡啶 、 palladium on activated charcoal 、 1,1-二氯甲醚 、 环己烯 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 生成 N-[2-((2S,4aR,5aR,8S,9aS,9bS)-2,8-Diphenyl-hexahydro-bis[1,3]dioxino[5,4-b;4',5'-d]pyrrol-5-yl)-2-oxo-ethyl]-4-methyl-N-(3-oxo-3-phenyl-propyl)-benzenesulfonamide
  参考文献：
  名称：

  Synthesis of the chiral auxiliary 1,3:4,6-di-O-benzylidene-2,5-dideoxy-2,5-imino-D-iditol

  摘要：

  L-Mannitol 5, the precursor of the the C-2-symmetrical auxiliary 3B, was prepared in high yield by heterogeneous reduction of L-mannonic-gamma-lactone 4. The auxiliary 3B could be used for stereoselective photochemical synthesis of the L-proline derivative 2B. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0957-4166(96)00137-1

文献信息

• Synthesis of the chiral auxiliary 1,3:4,6-di-O-benzylidene-2,5-dideoxy-2,5-imino-D-iditol
  作者：Bernd Giese、Stephan N. Müller、Caroline Wyss、Hans Steiner

  DOI：10.1016/0957-4166(96)00137-1

  日期：1996.5

  L-Mannitol 5, the precursor of the the C-2-symmetrical auxiliary 3B, was prepared in high yield by heterogeneous reduction of L-mannonic-gamma-lactone 4. The auxiliary 3B could be used for stereoselective photochemical synthesis of the L-proline derivative 2B. Copyright (C) 1996 Elsevier Science Ltd