{2-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-ethoxy]-ethyl}-phosphonic acid monoethyl ester | 405116-82-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: {2-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-ethoxy]-ethyl}-phosphonic acid monoethyl ester
• 英文别名: 2-[2-(1,3-Dioxoisoindol-2-yl)ethoxy]ethyl-ethoxyphosphinic acid；2-[2-(1,3-dioxoisoindol-2-yl)ethoxy]ethyl-ethoxyphosphinic acid
• CAS: 405116-82-7
• 化学式: C₁₄H₁₈NO₆P
• 分子量: 327.274
• InChiKey: PSSQAYYDYFTIMH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  93.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  {2-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-ethoxy]-ethyl}-phosphonic acid monoethyl ester 在 草酰氯 、 N,N-二甲基甲酰胺 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 2-[2-[2-(Chloro-ethoxy-oxidophosphaniumyl)ethoxy]ethyl]isoindole-1,3-dione
  参考文献：
  名称：

  A general synthesis of ethyl 4-aminophenyl and ethyl 4-[amino(hydroxyimino)methyl]phenyl phosphonates

  摘要：

  Diethyl phosphonates were conveniently converted into ethyl 4-aminophenyl and ethyl 4-[amino(hydroxyimino)methyl]phenyl phosphonates as potentially useful intermediates for the preparation of functionalized phenyl phosponates. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)02100-1
• 作为产物：
  描述：

  2-(2-(2-bromoethoxy)ethyl)isoindoline-1,3-dione 在 sodium azide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 32.0h， 生成 {2-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-ethoxy]-ethyl}-phosphonic acid monoethyl ester
  参考文献：
  名称：

  A general synthesis of ethyl 4-aminophenyl and ethyl 4-[amino(hydroxyimino)methyl]phenyl phosphonates

  摘要：

  Diethyl phosphonates were conveniently converted into ethyl 4-aminophenyl and ethyl 4-[amino(hydroxyimino)methyl]phenyl phosphonates as potentially useful intermediates for the preparation of functionalized phenyl phosponates. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)02100-1

文献信息

• A general synthesis of ethyl 4-aminophenyl and ethyl 4-[amino(hydroxyimino)methyl]phenyl phosphonates
  作者：Stanislav Gobec、Katja Štrancar、Uroš Urleb

  DOI：10.1016/s0040-4039(01)02100-1

  日期：2002.1

  Diethyl phosphonates were conveniently converted into ethyl 4-aminophenyl and ethyl 4-[amino(hydroxyimino)methyl]phenyl phosphonates as potentially useful intermediates for the preparation of functionalized phenyl phosponates. (C) 2001 Elsevier Science Ltd. All rights reserved.