N-[[(2S)-4,4-二氟-2-吡咯烷基]甲基]氨基甲酸叔丁酯 | 1363384-66-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 中文名称: N-[[(2S)-4,4-二氟-2-吡咯烷基]甲基]氨基甲酸叔丁酯
• 英文名称: (S)-2-(Boc-aminomethyl)-4,4-difluoropyrrolidine
• 英文别名: tert-butyl N-[[(2S)-4,4-difluoropyrrolidin-2-yl]methyl]carbamate
• CAS: 1363384-66-0
• 化学式: C₁₀H₁₈F₂N₂O₂
• 分子量: 236.26
• InChiKey: KEWAAHJOSNDLHV-ZETCQYMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  50.4
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS
  申请人：Janssen Pharmaceutica NV

  公开号：EP3426664B1

  公开（公告）日：2021-06-30
• NOVEL SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS
  申请人：Janssen Pharmaceutica NV

  公开号：US20200289539A1

  公开（公告）日：2020-09-17

  The present invention relates novel substituted nucleoside analogues of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.