1,1'-Benzene-1,2-diyldipyrrolidine-2,5-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1,1'-Benzene-1,2-diyldipyrrolidine-2,5-dione
• 英文别名: 1-[2-(2,5-dioxopyrrolidin-1-yl)phenyl]pyrrolidine-2,5-dione
• 化学式: C₁₄H₁₂N₂O₄
• 分子量: 272.26
• InChiKey: LEMJXBRSYXIHAY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  74.8
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Binding agents with differential activity
  申请人：Stevenson Telford George

  公开号：US20050031626A1

  公开（公告）日：2005-02-10

  Binding agents with differential activity can be provided, whereby certain activities of a first part of the binding agent are reduced or prevented until binding to a target occurs. This is useful if the binding agent is intended to bind both an effector cell and a target to be destroyed, because the effector cell can be protected from significant cell damage that might otherwise occur (e.g. due to premature activation of complement and/or ADCC). Such binding agents are useful in the treatment of cancer, for example.

  可以提供具有不同活性的结合剂，从而降低或阻止结合剂第一部分的某些活性，直到与目标物结合。如果结合剂既要与效应细胞结合，又要与待破坏的靶点结合，这就非常有用，因为效应细胞可以得到保护，避免可能发生的重大细胞损伤（例如，由于补体和/或 ADCC 的过早激活）。这种结合剂可用于治疗癌症等。
• BINDING AGENTS WITH DIFFERENTIAL ACTIVITY
  申请人：THE UNIVERSITY OF SOUTHAMPTON

  公开号：EP1412389A1

  公开（公告）日：2004-04-28
• [EN] BINDING AGENTS WITH DIFFERENTIAL ACTIVITY<br/>[FR] AGENTS LIANTS A ACTIVITE DIFFERENTIELLE
  申请人：UNIV SOUTHAMPTON

  公开号：WO2003011909A1

  公开（公告）日：2003-02-13

  Binding agents with differential activity can be provided, whereby certain activities of a first part of the binding agent are reduced or prevented until binding to a target occurs. This is useful if the binding agent is intended to bind both an effector cell and a target to be destroyed, because the effector cell can be protected from significant cell damage that might otherwise occur (e.g. due to premature activation of complement and/or ADCC). Such binding agents are useful in the treatment of cancer, for example.