1,5-tetramethyleno-2,4,6,8-tetra(hydroxymethyl)glycoluril

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 1,5-tetramethyleno-2,4,6,8-tetra(hydroxymethyl)glycoluril
• 英文别名: 7,9,10,12-Tetrakis(hydroxymethyl)-7,9,10,12-tetrazatricyclo[4.3.3.01,6]dodecane-8,11-dione
• 化学式: C₁₂H₂₀N₄O₆
• 分子量: 316.314
• InChiKey: VBJSUTBTVWHVGT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  128
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1,5-tetramethyleno-2,4,6,8-tetra(hydroxymethyl)glycoluril 、 L-methionine potassium salt 以 水 为溶剂， 反应 2.0h， 以87%的产率得到(S,S)-2-[8b,8c-tetramethyleno-6-(1-carboxy-2-methylthiopropyl)-4,8-dioxotetrahydro-2,3a,4a,6,7a,8a-hexaazacyclopenta[def]fluoren-2-yl]-4-methylthiobutanoic acid
  参考文献：
  名称：

  Synthesis of enantiomerically pure fused polyheterocyclic glycolurils based on (S)- α-amino acids

  摘要：

  The synthesis of tetra- and pentacyclic fused heterocyclic systems based on the condensation of (S)-alpha-amino acids with achiral 2,4,6,8-tetra(hydroxymethyl)- and 1,5-butano-2,4,6,8-tetra(hydroxymethyl)glycolurils has been developed.

  DOI：

  10.1016/j.mencom.2007.11.006

文献信息

• Synthesis of enantiomerically pure fused polyheterocyclic glycolurils based on (S)- α-amino acids
  作者：Il’ya E. Chikunov、Angelina N. Kravchenko、Nina N. Makhova

  DOI：10.1016/j.mencom.2007.11.006

  日期：2007.11

  The synthesis of tetra- and pentacyclic fused heterocyclic systems based on the condensation of (S)-alpha-amino acids with achiral 2,4,6,8-tetra(hydroxymethyl)- and 1,5-butano-2,4,6,8-tetra(hydroxymethyl)glycolurils has been developed.