7-Methyl-4-oxo-3,4-dihydro-pteridin | 34244-80-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 英文名称: 7-Methyl-4-oxo-3,4-dihydro-pteridin
• 英文别名: 7-Methylpteridin-4(3H)-on；7-methyl-3H-pteridin-4-one；7-Methyl-3H-pteridin-4-on；4(3H)-Pteridinone, 7-methyl-；7-methyl-3H-pteridin-4-one
• CAS: 34244-80-9
• 化学式: C₇H₆N₄O
• 分子量: 162.151
• InChiKey: ZFKCYEYVBSXGLU-UHFFFAOYSA-N

物化性质

• 沸点：
  288.83°C (rough estimate)
• 密度：
  1.3352 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  67.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  7-Methyl-4-oxo-3,4-dihydro-pteridin 在 溴 、 溶剂黄146 作用下， 生成 7-bromomethyl-3H-pteridin-4-one
  参考文献：
  名称：

  Brown, Journal of the Chemical Society, 1953, p. 1644

  摘要：

  DOI：
• 作为产物：
  描述：

  丙酮醛 、 4,5-二氨基-6-羟基嘧啶 在 sodium sulfite 作用下， 生成 7-Methyl-4-oxo-3,4-dihydro-pteridin
  参考文献：
  名称：

  Albert et al., Journal of the Chemical Society, 1952, p. 4219,4220

  摘要：

  DOI：

文献信息

• SILICON BASED DRUG CONJUGATES AND METHODS OF USING SAME
  申请人：BlinkBio, Inc.

  公开号：US20170202970A1

  公开（公告）日：2017-07-20

  Described herein are silicon based conjugates capable of delivering one or more payload moieties to a target cell or tissue. Contemplated conjugates may include a silicon-heteroatom core, one or more optional catalytic moieties, a targeting moiety that permits accumulation of the conjugate within a target cell or tissue, one or more payload moieties (e.g., a therapeutic agent or imaging agent), and two or more non-interfering moieties covalently bound to the silicon-heteroatom core.

  本文描述了基于硅的共轭物，能够将一个或多个有效载荷基团传递到靶细胞或组织。考虑到的共轭物可能包括一个硅-杂原子核心，一个或多个可选的催化基团，一个定位基团，允许共轭物在靶细胞或组织内积累，一个或多个有效载荷基团（例如，治疗剂或成像剂），以及与硅-杂原子核心共价结合的两个或更多个不干扰基团。
• Epoxy resin structural adhesive composition having high temperature resistance
  申请人：LORD CORPORATION

  公开号：EP0596622A2

  公开（公告）日：1994-05-11

  A structural adhesive composition containing an epoxy compound, an amine hardener and a hydroxy-substituted aromatic compound having a pKa ranging from about 5 to 9.7 and a boiling point greater than about 210°C. The utilization of a hydroxy-substituted aromatic compound having a pKa and a boiling point within the stated ranges provides for an adhesive composition which develops significant green strength, undergoes minimal sinkage during the bonding and curing process, and is capable of withstanding high temperature conditions.

  一种结构粘合剂组合物，含有环氧化合物、胺固化剂和羟基取代的芳香族化合物，其 pKa 在 5 至 9.7 之间，沸点高于 210°C。使用 pKa 和沸点均在上述范围内的羟基取代芳香族化合物制成的粘合剂组合物具有显著的生坯强度，在粘合和固化过程中下沉最小，并能承受高温条件。
• C2-CARBOCYCLIC IMINOTHIAZINE DIOXIDES AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE
  申请人：Merck Sharp & Dohme Corp.

  公开号：US20170114065A1

  公开（公告）日：2017-04-27

  In its many embodiments, the present invention provides certain C2-carbocyclic iminothiazine dioxide compounds, including compounds Formula (I); or a tautomers thereof, and pharmaceutically acceptable salts of said compounds and said tautomers, wherein R 1 , R 2 , ring A, R A , m, ring B, RB, n, ring C, R C and p are as defined herein. The novel compounds of the invention are useful as BACE inhibitors and/or for the treatment and prevention of various pathologies related thereto. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use, including for the possible treatment of Alzheimer's disease, are also disclosed.
• US5385990A
  申请人：——

  公开号：US5385990A

  公开（公告）日：1995-01-31
• US9732088B2
  申请人：——

  公开号：US9732088B2

  公开（公告）日：2017-08-15